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Biomedical subjects

G M Constantinescu

Publications and source records attributed to G M Constantinescu.

At least 19 recordsLinked to original sources

An anatomical study of the arteries feeding the triceps brachii muscle of swine.

The arterial vascular network of the porcine triceps brachii muscle (TBM) (an extensor muscle to the forearm) was studied and compared to another extensor muscle (the soleus muscle) of small rodents. The left axillary arteries (LAA) of nine Yucatan miniature swine were perfused with latex material to reveal the organization of the arterial blood supply to the TBM. Blood is supplied to the TBM by the main branches of the LAA. Some of the branches end in one of the four heads of the TBM. Other branches continue to bifurcate further and to supply blood to adjacent muscles. The feed arteries (FAs) arise as side-branches at regular distances from the branches of the LAA. The mean number of FAs per TBM was 109.7 and the mean diameter was 388 microns. The distribution of FAs to the muscle area is heterogenous. Most FAs penetrate the epimysium of the TBM on its medial aspect. It appears that more FAs come out of the branches of LAA that end in the TBM as compared to arteries which continue to bifurcate away from TBM. FA diameters were in the range of 300 microns. This study is the first necessary step towards understanding the distribution of oxygen and nutrients to the porcine skeletal muscle. It reveals the presence of a more complicated vascular network than that observed previously in small laboratory animals.

Animals↗

Subtotal colectomy and ileocolonic anastomosis in a Vietnamese pot-bellied pig with idiopathic megacolon.

A 7-month-old sexually intact female Vietnamese pot-bellied pig was evaluated because of constipation. On abdominal palpation, a hard tubular structure was palpated in the middle of the abdomen. Abdominal radiography revealed loops of intestine that were markedly distended with ingesta, consistent with obstructive intestinal disease. On exploratory celiotomy, a massively distended cecum and spiral colon were found. A subtotal colectomy, with a side-to-side ileocolonic anastomosis, was performed. The cause of the megacolon was not discovered. The pig did well following surgery and eventually defecated normally following an initial period of diarrhea. To our knowledge, this is the first report of therapeutic removal of a substantial portion of the large intestine in swine. Our decisions concerning the pig of this report were based largely on our knowledge of megacolon in cats. The outcome for this pig indicates that subtotal colectomy along with removal of the cecum and ileocecal valve can be used to successfully treat idiopathic megacolon in Vietnamese pot-bellied pigs.

Anastomosis, Surgical↗

Surgery of the adnexa.

Review of the functional anatomy of ocular adnexal tissues is followed by presentation of surgical procedures aimed at correcting conditions of the eyelids, conjunctiva, and third eyelids of small animals. Procedures used effectively by the primary author are described in detail including instances where combination procedures may be indicated. Some newer, recently described techniques are also briefly discussed. Illustrations of applied anatomy and multiple surgical techniques are provided by illustrator and coauthor Dr. Gheorghe Constantinescu. References are given to encourage readers to further explore alternative techniques focusing on the surgical correction of adnexal diseases of dogs and cats.

Animals↗

Surgery for cataracts.

The advent of phacoemulsification has substantially improved the success rate of cataract surgery in dogs, whereas the development of artificial lens implantation has equally improved postoperative visual acuity. In this chapter information pertaining to the etiology, diagnosis, and management of canine cataracts is provided for the general practitioner. More detailed information on phacoemulsification and artificial lens implantation is provided for residents in training or practicing ophthalmologists that may be converting from extracapsular extraction.

Animals↗

Permanent urinary diversion in two Vietnamese pot-bellied pigs by extrapelvic urethral or urethropreputial anastomosis.

Permanent urinary diversion was performed in a Vietnamese pot-bellied pig to bypass apparent urethral obstruction at the level of the urethral recess and in a second pig to correct bleeding from perineal urethrostomy. In the first pig, extrapelvic anastomosis of the penile portion of the urethra to the pelvic portion of the urethra was performed. In the second pig, the penis was amputated and the pelvic portion of the urethra was anastomosed to the preputial epithelium, creating a urethropreputial conduit. Postoperatively, positive-contrast radiography demonstrated continuity of the anastomoses, and both pigs were able to urinate normally. The pig with the urethropreputial anastomosis developed hematuria and nocturia that were controlled by continuous administration of antibiotics and resolved following cleansing of the preputial diverticulum 1 year after surgery. Extrapelvic urinary diversion should be considered for permanent resolution of urethral obstruction in Vietnamese pot-bellied pigs; urethral anastomosis is preferable to urethropreputial anastomosis, because of the greater risk of ascending urinary tract infection associated with urethropreputial anastomosis.

Anastomosis, Surgical↗

Stifle joint anatomy and surgical approaches in the dog.

This article reviewed the pertinent anatomy and surgical approaches of the canine stifle joint. Anatomically correct approaches to this joint provide for relatively atraumatic entry into the joint, while providing adequate exposure to complete the intra-articular parts of the surgical procedure. Atraumatic surgical exposures provide for less postoperative pain and a better outcome to any surgical procedure.

Animals↗

Perineal hernia in a cougar.

An 8-week-old female cougar with a history of acute perineal swelling was determined to have a perineal hernia. The hernia was repaired with the conventional suture technique. This case represents an unusual perineal hernia, which may have been congenital.

Animals↗

Multiple cardiac anomalies in a cat.

A 7-week-old domestic shorthair cat was examined because of congestive heart failure. Echocardiography and angiography were used to identify multiple cardiac anomalies. Because of the uncorrectable nature of the defects, the cat was euthanatized. Necropsy revealed persistent left vena cava, patent foramen ovale, and a right atrial/left ventricular canal. The right atrioventricular valve was replaced by a small ostium, and no chordae tendinae or papillary muscles were observed around the ostium. The pulmonary trunk originated from the right atrium. The right ventricular free wall was approximately 1 mm thick.

Angiography↗

Atlantoaxial malformation in a half-Arabian colt.

A 1-year-old half-Arabian colt was referred for evaluation of a cranial cervical abnormality. Physical examination revealed the left wing of the atlas to be more ventral than the right wing. A head tilt, with the pole deviated to the left, was present because of the malpositioned atlas. Neurologic examination identified symmetrical weakness, ataxia, and proprioceptive deficits in all four limbs. Radiographs of the cranial cervical region revealed fusion of the atlas and axis, and deviation of the atlantoaxial joint to the left of the median plane. Euthanasia was elected. Necropsy confirmed the radiographic findings. The atlas was rotated 20 degrees counterclockwise when viewed from the caudal aspect. Multifocal myelomalacia was present in the first and second cervical spinal cord segments. The malformation was believed to be due to a degenerative process or abnormal embryological development.

Animals↗

The anatomy of the visceral and autonomic nervous systems.

The visceral nervous system has several levels of anatomical organization. Individual viscera, including the heart and the intestines, have neural tissue embedded in their walls that is capable, under some circumstances, of a truly autonomic self-regulation of that organ's activity. This self-regulation will not respond to all the varying needs of the organ control, particularly when external or internal changes affect the whole animal. The parasympathetic, sympathetic, and visceral afferent systems and their CNS connections are the next level of reflex neural organization. A greater degree of central regulation is managed at this level. The third level of visceral control is located in the brainstem and includes the hypothalamus, parts of the reticular formation, and cardiorespiratory centers in the medulla. These visceral upper neuron centers exert a high degree of control over the parasympathetic and sympathetic LMN centers of the brainstem and spinal cord. The reticulobulbar and reticulospinal pathways are the means by which the visceral upper motor neurons communicate with the LMN systems. The hypothalamus-hypophyseal system exerts control by releasing hormones to act on distant target organs. The highest level of organization of visceral function takes place in the limbic system. The limbic system is in a position to integrate sensory information originating from both within (interoceptive) and outside (exteroceptive) the animal. Associations are made at this level and with the help of cortical association areas, memory is integrated with these sensations. The limbic system is then able to influence the hypothalamic and medullary centers as well as the somatic motor centers to develop the appropriate responses for the preservation of the animal.

Afferent Pathways↗

Anatomy of the orbital fasciae and the third eyelid in dogs.

The connective tissue structures commonly referred to as the periorbita, orbital septum, muscular fasciae, and vagina bulbi or collectively, as the orbital fasciae were dissected then illustrated and described. Two sheets (layers) of the periorbita (endorbita) were found in our dogs. The periorbita should be renamed endorbita because of its anatomic relations. The periorbita did not always fuse with the periosteum of frontal and sphenoid bones. Rather, the periorbita and the periosteum were often distinct and separate; only medioventrally did several fibrous bands unite the superficial sheet of the endorbita with the periosteum. Two layers of the endorbita fused with the periosteum of the margin of the bony orbit and with the orbital ligament. The muscular fasciae were divided into 3 layers. The superficial layer extended caudally from the orbital septum, was thick, and was pierced by arteries, veins, and nerves. The middle layer was attached to the sclerocorneal junction and, at the temporal canthus of the eye, was divided into superficial and deep sheets. The deep portion was attached to the lateral angle of the third eyelid, similar to a strong ligament. The deep layer of the muscular fasciae extended caudally from the sclerocorneal junction in intimate contact with recti and oblique muscles of the eyeball. The deep portion of the deep muscular fascia covered the deep surface of all recti muscles and separated them from the retractor bulbi muscle. Intermuscular septa were observed between middle and deep muscular fascia layers.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

Accessory parotid lymph nodes and hemal nodes in the temporal fossa in three oxen.

No description of accessory parotid lymph nodes in the ox was found in the 25 references consulted. Accessory parotid lymph nodes in two fresh ox heads were found. One of the lymph nodes was located in the temporal fossa on the cornual A., between the artery and the zygomatico- temporal N. and the other one on the route of the lacrimal br. (A) and external ophthalmic V., ventral to the zygomatico-temporal N. The lymph nodes were atypical. The supportive tissue was primarily smooth muscle, no subcapsular or cortical sinuses were seen; no medullary region was evident and the lymphatic tissue was diffuse with no evidence of nodule formation. Two hemal nodes were found in the second and a third fresh ox head obtained from the same source. Both were located on the route of the lacrimal br. of the cornual A. The largest hemal node was normal histologically, with blood-filled sinuses and prominent, active lymphatic nodules. The small hemal node was somewhat atypical in that no trabeculae penetrated the parenchyma and the cortical lymphatic tissue was diffuse with no nodule formation.

Animals↗

Anury in two Cairn terriers.

Congenital anury (taillessness) was observed in 2 Cairn Terriers. Fecal staining of the hind limbs was evident in both dogs. A mating of the affected dogs produced a litter of 2 apparently normal pups. The small litter size may have been attributable to lethal gene combinations similar to those described in mice. The radiographic appearance of the caudal and sacral vertebrae was atypical in both tailless dogs. Results of myelography and electrodiagnostic testing of anal sphincter function were normal in one of the dogs. One of the tailless dogs was euthanatized and was found to lack specific muscles and muscle parts responsible for normal defecation, which resulted in fecal staining of the hind limbs. Pedigree analysis revealed the tailless dogs to be closely related and slightly inbred, suggesting a hereditary etiologic factor for anury.

Animals↗

Complications of balloon catheterization associated with aberrant cerebral arterial anatomy in a horse with guttural pouch mycosis.

A 3-year-old Quarter Horse gelding was treated for left guttural pouch mycosis by ligation and balloon catheterization of the left internal carotid artery. Catheter advancement was shorter (10 cm) than the normally reported distance (13-15 cm), but was observed endoscopically during placement as it coursed within the internal carotid artery through the guttural pouch. The horse developed a persistently abnormal respiratory pattern after catheter placement, failed to gain consciousness, developed pulmonary edema, and died 5.5 hours postoperatively. Postmortem examination revealed an aberrant left internal carotid arterial course with location of the embolectomy catheter at the junction of the basilar and caudal cerebellar arteries. Brainstem neuronal necrosis and alveolar and interstitial pulmonary edema were identified on histological examination. Angiography may be used to identify aberrant branching patterns. Failure to identify and occlude aberrant branches may result in fatal epistaxis and Brainstem lesions.

Animals↗