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G M Elbakidze

Publications and source records attributed to G M Elbakidze.

5 recordsLinked to original sources
PubMed1979

[Respiration-stimulated activation of DNAase I associated with mitochondria].

The influence of respiration and Ca++ transport in the liver mitochondria on the activation of DNAase I, associated with these organelles, was studied. It was shown that 96% of the total activity of this enzyme in mitochondria is in the latent state. Aeration of the mitochondrial suspension leads to a sharp increase in the enzyme activity. The activation of DNAase I is inhibited by EGTA addition (optimal pH 8.0), and stimulated in mitochondria, releasing Ca++. It is concluded that the activation of DNAase I is dependent on the state of cellular energetics. Participation of mitochondrial phospholypase A, activated by the Ca++ release from mitochondria during DNAase I activation is suggested.

Aerobiosis↗
PubMed1979

[Tissue-specific uncouplers of oxidative phosphorylation in mitochondria from rat heart, kidney, thymus and lung].

The influence of nonmicrosomal cytoplasm fraction from the rat kidney, heart, thymus and lungs on the oxidative phosphorylation of mitochondria (M) of the same tissues and from the ones of the liver and brain was studied. The existence of the tissue-specific uncouplers of the M oxidative phosphorylation was shown in the cross experiments; they were similar to that in the rat liver revealed earlier. A possibility of these regulators participation in the initiation of the M enzymatic degradation process through the activation of phospholipase A when calcium ions leave the M is discussed. The activation under these conditions of the DNA-ase 1, associated with the M membrane, is suggested.

Animals↗