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Biomedical subjects

G M Ferguson

Publications and source records attributed to G M Ferguson.

5 recordsLinked to original sources
PubMed1995

Stiff wire manipulation of peritoneal dialysis catheters.

From January 1989 to June 1994 we examined the success rate of fluoroscopically guided stiff wire manipulation of malfunctioning peritoneal dialysis catheters (PDCs) at St. Paul's Hospital, Saskatoon. There were 341 (201 male, 140 female) patients with a PDC. There were 118 manipulations (70 initial, 48 remanipulations) for malposition, fibrin clot, or kinked catheter. Single-cuff Tenckhoff catheters accounted for 95% of manipulated PDCs. No complications including peritonitis, exit-site infections, ruptured catheter, or bowel perforation were reported postmanipulation. A successful manipulation was defined as a functional PDC at 30 days postmanipulation. There was an overall success rate of 64%-67% for initial manipulations (IM) and 48% for remanipulations (RM). Ninety percent of those PDCs requiring IM occurred within 42 days of surgical insertion. RM occurred on average 55 days after IM. There were no risk factors identified that predisposed patients for PDC manipulation. This success rate for combined IM and RM of PDCs is higher than those rates quoted in the literature (27%-42%). We conclude that fluoroscopically guided stiff wire manipulation of PDCs, including repeated attempts, is a safe and effective way of prolonging PDC life, thus avoiding the risks of repeated surgery, improving quality of life, and decreasing health care costs.

Adolescent↗
PubMed1994

Total hip arthroplasty after failed intertrochanteric osteotomy.

From 1969 through 1982, 305 hips in 290 patients had total hip arthroplasty for failed femoral intertrochanteric osteotomy. Of these, we reviewed 215 hips (70.5%) with a minimum follow-up of five years. The results were good or excellent in 79%, but there were technical problems at operation in 23% and a total perioperative complication rate of 11.8%. Late complications occurred in 13.1% including seven late infections (3.2%). At a mean follow-up of ten years, 39 hips had been revised (18.1%), there was probable loosening in 19.5% of stems and 12.6% of cups and possible loosening in 11.4% of stems and 7.2% of cups. The cumulative probability of failure at ten years was 20.6%. We recommend that intertrochanteric osteotomy be advised, planned and executed bearing in mind the possible need for a subsequent total hip arthroplasty, and that screws and plates should be routinely removed soon after union of the osteotomy.

Aged↗
PubMed1988

The synovial production of collagenase and chondrocyte activating factors in response to cobalt.

Addition of CoCl2 solutions to the culture media of confluent monolayers of lapine or human synoviocytes stimulated their production of the neutral proteinases collagenase, gelatinase, and caseinase. With lapine cells, maximum stimulation occurred at 10(-7) M CoCl2, while human cells required 10(-4)-10(-5) M CoCl2 to achieve a maximum stimulation. Production of prostaglandin E2 by lapine cells was enhanced some 30-40% by concentrations of CoCl2 that maximally stimulated synthesis of the neutral proteinases, whereas all concentrations of CoCl2 slightly depressed the production of prostaglandin E2 by human cells. Lapine synovial cells that had been stimulated by CoCl2 also produced a substance, or substances, that provoked the synthesis of collagenase, gelatinase, caseinase, and prostaglandin E2 by monolayers of articular chondrocytes. Chondrocytes themselves, however, resisted activation by CoCl2. These findings may be relevant to the aseptic loosening of joint prostheses.

Animals↗