Biomedical subjects
Publications and source records attributed to G M Korotaev.
The study was made of HBO effect on changes of biologic fluid toxicity in purulent peritonitis. HBO was introduced in combined therapy of 68 patients (32 with general peritonitis and 36 with peritoneal sepsis). Lethality in peritonitis patients reached 40.6% (19 patients), in sepsis patients 33.3% (12 patients).
The article generalizes the result of experimental study of the features of hemolymphodynamics, toxic properties of biological body fluids, and microbiological findings in peritonitis. Experiments were conducted on 24 dogs. The development of the pyogenic process was visually studied. For this purpose the opened abdominal cavity was placed in a specially constructed transparent chamber in which a temperature of 37 /*C was maintained. Portal blood flow intensified and lymph production in the abdominal cavity reduced in the initial phase of peritonitis. Later lymph production increased while the portal blood flow decreased. The purulent process may develop according to two variants. In the first variant the functional activity of the liver is maintained and its toxic products and microorganisms are detoxified; the second variant the detoxification function of the liver is disturbed, the bacteria penetrate the peripheral blood, the production and flow of lymph in the thoracic duct increase sharply. The efficacy of external drainage of the duct and lymphosorption is much higher in the second variant of peritonitis development than in the first variant.
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The stage-wise character of the course of sepsis is substantiated on the basis of an analysis of the central venous pressure parameters, central and peripheral hematocrite, pulse rate, respiration, ECG data and rheohepatograms in 81 patients with surgical sepsis. The stage-wise course of sepsis is also confirmed by specific hemodynamic reactions of the organism in response to the first session of HBO which allows to differentiate the indications for this kind of treatment.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.