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Biomedical subjects

G M Maclure

Publications and source records attributed to G M Maclure.

7 recordsLinked to original sources
PubMed1989

Effect on the 24-hour diurnal curve of intraocular pressure of a fixed ratio combination of timolol 0.5% and pilocarpine 2% in patients with COAG not controlled on timolol 0.5%.

Eight patients with chronic open-angle glaucoma who had an intraocular pressure greater than 24 mm Hg at some time during the day while taking timolol 0.5% twice daily were given the fixed ratio combination of timolol 0.5% with pilocarpine 2% (TP2) twice daily. By comparing full 24-hour diurnal curves on timolol with those on TP2 it was possible to show that all patients except one (at a single timepoint) had an IOP less than 22 mm Hg when changed to TP2. The mean IOPs, the area under the diurnal pressure curve, and the diurnal variation were all significantly lower on TP2 twice daily than on timolol 0.5% twice daily.

Aged↗
PubMed1983

Chronic open angle glaucoma treated with Timolol. A four year study.

Many reported series of patients treated with topical Timolol for chronic open angle glaucoma have been changed from other medication after a 'wash-out' period. This four year study reports the ocular hypotensive effect of Timolol in 82 new patients with chronic open angle glaucoma followed for up to 4.5 years. The effects on intraocular pressure, visual acuity, visual field, pupil size, pulse rate, blood pressure and Schirmer's test were recorded and correlated. Corneal sensitivity was also followed in some patients, matched by a series of controls, using the method of Cochet and Bonnet. The results are discussed, and only slight reduction in blood pressure and pulse rate was found, and there was no significant effect on the pupil diameter or Schirmer's test. There was no significant effect on corneal sensitivity. There was only slight tachyphylaxis. Of the 82 patients, 20 patients required extra medical or surgical treatment. 16 patients dropped out through death or failure to attend, and of the remaining 66 patients, 69.7 per cent were controlled by Timolol alone.

Adult↗
PubMed1980

Reading type for children.

Young children experience difficulty with the present reading charts, and it may not be easy to decide whether this is due to visual problems or is associated with a deficient reading ability of the material presented to them. A reading chart has therefore been designed containing material graded according to the expected average ability for different age groups. The earlier grades use 'school script' print as well as Times Roman, which is used entirely for the older age groups. Selected words, reduced distance charts, a school script distance chart, and a standard distance chart, as well as some coloured pictures, are included.

Age Factors↗