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Biomedical subjects

G M Maxwell

Publications and source records attributed to G M Maxwell.

65 records · Page 4Linked to original sources
PubMedDate not supplied

Effect of nisoldipine upon the general and coronary hemodynamics of the anesthetized dog.

The effect of nisoldipine (5 micrograms/kg/i.v.) was studied in anesthetized intact dogs. This calcium antagonist increased heart rate by 68%, doubled cardiac output, and increased coronary sinus flow from 62 +/- 10 ml/min to a maximum of 131 +/- 7 ml/min. Mean systemic pressure decreased from 125 +/- 10 mm Hg to a minimum of 115 +/- 2 mm Hg for at least 15 min after the injection. Mean pulmonary artery pressure increased from 12 +/- 2 mm Hg to 18 +/- 4 mm Hg within 2 min of the injection. Left ventricular work (joules/s) doubled and right ventricular work trebled during the first 15 min after injection. Peripheral resistance fell by 57%, total pulmonary resistance by 40%, and coronary vascular resistance by half. Coronary sinus O2 content increased by 50%, and cardiac efficiency (index) increased from 0.2 (control) to a maximum of 0.46, within 2 min after the injection of the drug.

Anesthesia↗
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The effects of 3-hydrazine-6[N,N-bis(2-hydroxyethyl)-amino]-pyridazine dihydrochloride (L6150) on the general and cardiac haemodynamics of the intact dog.

1. The effects of 3-hydrazine-6[N,N-bis(2-hydroxyethyl)amino]-pyridazine dihydrochloride (L6150) were studied in intact anaesthetized dogs. 2. In a dose of 1 mg/kg/(i.v.) the drug increased respiration rate, cardiac output, and left and right ventricular work. 3. It decreased femoral pressure and systemic and total pulmonary resistance. 4. It increased coronary flow and coronary sinus O2 content. 5 The drug also increased whole body glucose, lactate, pyruvate and NEFA values.

Animals↗
PubMedDate not supplied

The effects of an histamine H2-receptor agonist, impromidine (SK & F 92676) on the general and cardiac haemodynamics of the intact dog.

1. The effects of impromidine (16 nmol/kg intravenously) were studied in the general and coronary circulations of the intact anaesthetized dog. 2. The drug caused tachycardia, increased cardiac output and coronary sinus flow, and induced minor changes in systemic and pulmonary arterial pressures. 3. It increased left and right ventricular work, and decreased calculated resistance values in the greater and lesser circulations. Coronary vascular resistance fell, cardiac O2 extraction increases. 4. These changes were substantially prevented by treatment with cimetidine. 5. The action of an H2-receptor agonist then is associated with a general and coronary vasodilator response, with maintenance of calculated cardiac efficiency.

Animals↗