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Biomedical subjects

G M Newcomb

Publications and source records attributed to G M Newcomb.

32 records · Page 2Linked to original sources
PubMed1982

Association between plaque accumulation and Langerhans cell numbers in the oral epithelium of attached gingiva.

After gingival health had been achieved in four subjects they were instructed to cease all oral hygiene measures. At 0, 8 and 21 days Plaque and Gingival Indices were recorded and gingival biopsies were removed from the buccal aspect of a first molar. Frozen sections of the gingival oral epithelium were stained for ATPase and 5'-nucleotidase to determine the number of Langerhans cells in a defined cross-sectional area. It was found that, as plaque accumulated, there was a statistically significant increase in the number of Langerhans cells in oral epithelium, particularly in the stratum spinosum. These results indicate that dental plaque can elicit a response in Langerhans cells located in the oral epithelium of the gingiva.

Adult↗
PubMed1980

Scanning electron microscope histochemistry: the use of backscattered electrons to identify epidermal Langerhans cells in the scanning electron microscope.

Epidermal sheets reacted for ATPase were examined in the scanning electron microscope and images based on atomic number contrast formed by collecting the backscattered electrons. Langerhans cells lying within the tissue were revealed and could be related to surface structures by reference to conventional secondary electron images.

Adenosine Triphosphatases↗
PubMed1978

A clinical study of gingival inflammation in renal transplant recipients taking immunosuppressive drugs.

The relationship between the gingival inflammation and plaque scores of patients who had received kidney transplants and were taking immunosuppressive drugs to combat rejection pheomena was compared with data from a control group. Equivalent plaque scores were associated with less gingival inflammation in the patients taking the immunosuppressive drugs. While there was no signficant difference between the plaque scores of the two groups the control group displayed signficantly more gingival inflammation. The implications of these results with respect to possible etiological mechanisms operating in periodontal disease are discussed.

Adolescent↗
PubMed1977

An in vivo comparison of chlorhexidine and picloxydine mouthrinses: a possible association between chemical structure and antiplaque activity.

A double blind clinical trial was conducted in which both the plaque-inhibiting ability and the in vivo effects on the oral flora of chlorhexidine and picloxydine mouthwashes was compared. While picloxydine in higher concentration suppressed the oral flora more effectively than chlorhexidine, the latter agent inhibited plaque development to a much greater extent. This lack of correlation between antibacterial and antiplaque activity can be related to structural differences between these two bis-biguanides.

Bacteria↗