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Biomedical subjects

G M Pearl

Publications and source records attributed to G M Pearl.

5 recordsLinked to original sources
PubMed2001

Integration of computational analysis as a sentinel tool in toxicological assessments.

Computational toxicity modeling can have significant impact in the drug discovery process, especially when utilized as a sentinel filter for common drug safety liabilities, such as mutagenicity, carcinogenicity and teratogenicity. This review will focus on the strengths and limitations of the current computational models for predicting these drug safety liabilities, and the various strategies for incorporating these predictive models into the drug discovery process.

Animals↗
PubMed2001

Fiscal options for America's best hospitals.

A review of America's "best" teaching hospitals shows a huge disparity in their fiscal positions. Among the 15 hospitals studied, roughly half experience some fiscal distress. However, a somewhat similar fiscal analysis of the nation's largest investor-owned hospital chains, HMOs, and physician practice management corporations shows an even more serious weakness in operating margins and debt-equity ratios. Aside from raising possible ethical, quality, and cost issues, this financial analysis suggests that conversion from nonprofit to for-profit ownership of America's top teaching hospitals might not guarantee an improvement in their long-term fiscal outlook.

Accounts Payable and Receivable↗
PubMed2001

Computational methods to predict drug safety liabilities.

Computational methods to predict drug safety liabilities are reviewed. A special emphasis of this article is on the perceived strengths and weaknesses of the commercial turnkey predictive toxicology programs (TOPKAT, MULTICASE and DEREK). This article includes proposals for improvements of individual predictive programs, experiences with pharmaceutical datasets, evaluations incorporating multiple programs, and strategies of their use as a sentinel filter for liability assessment early in the drug discovery process.

Animals↗
PubMedDate not supplied

Merger mania: physicians beware.

Corporate consolidations, mergers, and acquisitions would seem to provide immense promise in furthering the development of health networking because they affect the governance of entire organizations, rather than simply establishing revised arrangements for specific services or patients. Yet, a limited number of empirical studies have been published to date that explore whether hospital mergers actually improve access, reduce cost, or improve quality of care; and, among the reports available, the conclusions are somewhat equivocal. Physicians should be cautious of these mergers, since they seem to focus either on eliminating a direct competitor or on forming a large horizontally and vertically diversified health network that then can become a major player in gaining exclusivity in managed care contracting. With either of these merger strategies, there are antitrust-type concerns that competition among physicians and other providers will be significantly curtailed, and that consumers will end up with fewer choices in obtaining cost effective, quality patient care.

Antitrust Laws↗