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Biomedical subjects

G M Schaeffer

Publications and source records attributed to G M Schaeffer.

5 recordsLinked to original sources
PubMed1987

Correlation between tissue damage and malondialdehydemia in mice infected with Trypanosoma cruzi.

Evolution of the acute phase of experimental Chagas' disease was correlated with tissue damage and plasma levels of malondialdehyde. Heart lesions were quantified by the Tissue Damage Unit (TDU) and malondialdehydemia (MDA) by the colorimetric determination of malondialdehyde. The binary correlations were: C(X,Y) = 0.965 (P less than 0.001); C(Y,Z) = 0.784 (P less than 0.01); and C(X,Z) = 0.824 (P less than 0.01), where X = days of infection, Y = TDU means and Z = MDA means. These results show a positive correlation between the duration of the acute phase of experimental Chagas' disease and TDU, and between the duration and MDA. The methods for measuring tissue damage and MDA are shown to be simple and adequate for monitoring tissue aggression in the protozoosis studied.

Animals↗
PubMed1987

Malondialdehydemia and parasitemia during acute phase of experimental Chagas' disease in mice.

Parasitemia and malondialdehydemia were compared during the acute phase of the infection caused by the CL and Y strains of T. cruzi. Parasitemia was measured by counting blood trypomastigote forms, and malondialdehydemia by a colorimetric method. The duration of the acute phase of Chagas' disease was correlated with malondialdehydemia in both CL and Y strains. The correlations between parasitemia and duration of the acute phase, as well as between parasitemia and malondialdehydemia, were significant only in the group infected with the CL strain. These data suggest that malondialdehydemia may be an adequate parameter for evaluating and monitoring the acute phase in experimental Chagas' disease.

Acute Disease↗
PubMed1980

Phospholipids associated with vitamin C in experimental atherosclerosis.

The favourable action of phospholipids and of Vitamin C in reverting the process of atherogenesis, already repeatedly described in the literature, was explored by the authors in applying an association of these two substances in experimental atherosclerosis. The obtained results not only confirm, once again, the prophylactic and therapeutic activity of phospholipids and vitamin C, but also demonstrate that these components, when associated, lead to much better results in the prevention and resolution of atheromatous plaques provoked in rabbits by cholesterol-feeding.

Animals↗