Biomedical subjects

G M Strathy

Publications and source records attributed to G M Strathy.

4 recordsLinked to original sources

PubMed1988

Total hip arthroplasty in the ankylosed hip. A ten-year follow-up.

Eighty total hip arthroplasties in seventy-four patients who had had either a spontaneous or a surgical ankylosis (arthrodesis) of the hip were evaluated at nine to fifteen years (average, 10.4 years) after the total hip replacement. There was only one failure in the twenty hips of the fifteen patients who had had a spontaneous ankylosis. In contrast, twenty (33 per cent) of the sixty hips of the sixty patients who had had a surgical ankylosis had complications that were associated with the arthroplasty. Of these twenty hips, mechanical loosening developed in eleven; infection, in eight; and recurring dislocation, in one. Failure of the total hip arthroplasty was more common (p less than 0.05) in the patients who had had a previous surgical attempt at arthrodesis and in the patients who were fifty years old or less at the time of the arthroplasty. The risk of failure was not related to the length of time that the hip had been ankylosed.

Activities of Daily Living↗

PubMed1987

Effects of anti-inflammatory drugs on cartilage recovery from catabolin-induced degradation.

Effects of aspirin (200 micrograms/ml), hydrocortisone (10 micrograms/ml), sodium aurothiomalate (100 micrograms/ml), and indomethacin (10 micrograms/ml) on recovery of cartilage from interleukin 1 or catabolin-induced degradation were examined in this initial in vitro study. The experimental protocol involved a "degradative phase" of eight days during which cartilage plugs were incubated in the presence or absence of spent human rheumatoid synovial culture media. A "recovery" period of six days followed during which the effects of the aforementioned drugs on treated cartilage were analyzed. Incorporation of [35S]sulfate and [3H]proline precursors, and total contents of hydroxyproline and glycosaminoglycan in cartilage were determined two, four, and six days after insult. Aspirin treatment caused a rise in total proteoglycan content over degraded controls (p less than 0.002), however, this increase was not associated with increased [35S]sulfate incorporation into glycosaminoglycans. Hydrocortisone resulted in a delayed rise in proteoglycan content concommitant with increased [35S]sulfate uptake, whereas sodium aurothiomalate treatment was without effect on proteoglycans. Indomethacin treatment was associated with an increased release of newly synthesized macromolecules by cartilage into the media (p less than 0.01). These results suggest that common anti-inflammatory drugs may exhibit distinctly different effects on the in vitro synthesis and retention of proteoglycans by cartilage explants previously exposed to a degradative phase. Further work is necessary to assess the influence of drug concentration in this experimental system.

Anti-Inflammatory Agents↗

PubMed1984

Ender's pinning for fractures about the hip.

In this study, we reviewed retrospectively our first 4 years of experience with treatment of hip fractures with Ender's pinning in an effort to determine the related problems and the types of fractures for which this procedure is the most effective. Of the 77 fractures in our series, 59 cases were available for follow-up evaluation. Knee pain was reported by 41% of the patients. Overall, 31% of the group underwent additional surgical procedures, primarily because of distal migration of the pins. On the basis of our results, we recommend that Ender's pinning be reserved for treatment of basilar neck and type I intertrochanteric fractures in patients who cannot tolerate a more extensive procedure.

Aged↗

PubMed1983

Changes in knee function associated with treadmill ambulation.

A comparison of level walking, on a walkway and on a treadmill, was performed using ten normal subjects. Motion about the knee was measured using a triaxial electrogoniometer, and foot-floor contact patterns were recorded by means of four foot switches attached to the sole of each shoe. On the walkway, the data were collected with the subject moving at a comfortable walking speed. The treadmill was then set at the average velocity obtained on the walkway. Knee joint rotation in the coronal and transverse planes did not change significantly between the walkway and the treadmill. In the sagittal plane, significant differences were found for total motion (p less than 0.01), swing phase motion (p less than 0.01), knee position at heel strike (p less than 0.05), and maximum swing phase extension (p less than 0.01). A comparison of the foot-floor contact patterns between walkway and treadmill ambulation revealed reduced heel contact time, with an increase in toe contact while on the treadmill. It was concluded that sagittal plane knee kinematics during level treadmill walking differ significantly from level overground walking.

Adult↗