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Biomedical subjects

G M Zavarise

Publications and source records attributed to G M Zavarise.

8 recordsLinked to original sources

[Cutaneous tuberculosis with multifocal visceral involvement].

The case of a young Senegalese man who developed a form of cutaneous tuberculosis associated with a disseminated disease, successfully treated with appropriate antitubercular chemotherapy is reported. We found Mycobacterium Microti in the cutaneous ulcers, the only organism isolated after many cultural and microscopical examinations of different exudates and tissues. This mycobacterium was considered up to now to be pathogenic to rodents, but not man. Its possible pathogenicity to man (under certain situations) is also suggested, and it is expected that this possibility will be supported by other reports in the near future. In addition, stress is laid on the problems of diagnosis and classification of the cutaneous tuberculosis, so uncommon in the Western Hemisphere, and its possible association with leprosy.

Antitubercular Agents↗

[Pseudohypoparathyroidism. Analysis of a clinical case with late development].

A case of pseudohypoparathyroidism of characteristic phenotype and metabolism is described. The condition was diagnosed at over 50 years of age following the appearance of hypocalcaemia and calcification of basal ganglia which responded quickly to treatment with vitamin D and orally administered calcium. This case gives the opportunity to describe a rare hereditary disease and discuss which mechanisms triggered off the symptomatology: mechanisms which involve PTH, the action of which is still not fully known.

Calcinosis↗

[Effect of some anticoagulant drugs on granulocyte capillary migration].

We have investigated the effect of four anticoagulant drugs (Calbiochem Heparin, Liquemin Roche, EDTA and Na citrate) on polymorphonuclear granulocyte capillary migration to evaluate a possible modification induced by these drugs on migration function. We can state that any modification is induced by these drugs on granulocyte capillary migration in vitro.

Anticoagulants↗

Effect of single oral dose of phenobarbitone on lymphocyte blastogenic response in man.

A single oral dose of phenobarbitone 1.5 mg kg-1 was given to 18 normal subjects to evaluate the effects on lymphocyte function. Serum barbiturate concentrations and lymphocyte blastogenic response to three mitogens (PHA, Con A, PWM) were tested before and at 2, 12 and 36 h after drug administration. A serum barbiturate plateau of about 2 microgram ml-1 was maintained from 2 to 36 h. Lymphocyte blastogenesis was reduced with barbiturate compared with controls. However, the reduction was significant only at 36 h (P < 0.01).

Adult↗