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Biomedical subjects

G Möbius

Publications and source records attributed to G Möbius.

At least 19 recordsLinked to original sources
PubMed2005

Comparison of tenoscopic and ultrasonographic methods of examination of the digital flexor tendon sheath in horses.

The purpose of this study was to compare sonographic and tenoscopic findings with the purpose of establishing the accuracy and limitations of ultrasonograophy as a non-invasive diagnostic modality in evaluating the DFTS and its enclosed tendons. The medical records from 22 horses which underwent tenoscopic desmotomy of the palmar/plantar annular ligament were evaluated in a retrospective study. The qualitative assessment of sonogrophic and tenoscopic findings were documented for the digital flexor tendon sheath (DFTS), the palmar/plantar annular ligament (PAL), the superficial digital flexor tendon (SDFT) and the deep digital flexor tendon (DDFT). The abnormalities diagnosed sonographically within the DFTS were verifiable tenoscopically with a sensitivity of 90.9% and a specificity of 53.8%. The positive predictive value of sonographic examination at the DFTS was 62.5%. The sensitivity of the sonographic examination at the PAL was 68.8%, the specificity was 50% and the positive predictive value 73.3%. Sonographic examination of the SDF tendons revealed abnormal findings in 12 tendons. The tenoscopic examination confirmed these findings on six tendons when they had a pronounced fibrillated or rough tendon surface or tear on the border. Six superficial flexor tendons and seven deep digital flexor tendons had abnormalities seen tenoscopically which were not visible on sonographic examination. Sonographic examination located lesions of the DDFT in four limbs. On tenoscopic examination the lesions could be detected in seven other DDF tendons, including signs of inflammation at the tendon surface that were not seen ultrasonographically (sensitivity 36.4%). Recognition of the limitations of sonographic results should be kept in mind so as not to misinterpret findings, especially if echogenic materials are observed.

Animals↗
PubMed1998

[Sled dog racing and animal welfare aspects].

Transport, housing and the dimensions of strain during training and race are important aspects of animal welfare. The race veterinarian has a great responsibility. He is responsible for the treatment of injured dogs and he has to give advice on all medical and animal welfare questions. The presence of the veterinarian during the entire race is very important. These veterinarians should have special knowledge of small animals and of sled dogs in particular. There should be health checks of sled dogs before and after racing similar to horse sport tournaments.

Animal Welfare↗
PubMed1995

Varieties of serous surface papillary carcinoma of the peritoneum in northern Germany: a thirty-year autopsy study.

From a total of 62,858 autopsy files kept over a 30-year period (1961-1990), all cases that met the following criteria were extracted: (a) main tumor masses in the peritoneum with no evidence of origin from any adjacent organ; (b) histologic features suggestive of serous ovarian carcinoma; (c) ovaries definitely recognizable as having either no tumorous involvement or tumor confined to the surface and cortex of the ovaries; and (d) in patients with a history of abdominal operations, availability of slides and reports. From 670 stages III and IV serous carcinomas of the ovary, we retrieved 57 cases (8%) of serous surface papillary carcinoma (SSPC) of the peritoneum. All SSPCs occurred in women with an age range from 47 to 84 years (median 66 years). Eight cases (14%) were grade I, 36 (63%) were grade II, and 13 (23%) were grade III. Histologically, four cases (7%) resembled malignant epithelial mesothelioma in major parts of the tumor, and in one case endometrioid differentiation of the tumor was conspicuous. Additional histochemical and immunohistochemical examinations were performed in 30 cases of SSPC. In 14 cases (47%) neutral mucosubstances were identified by periodic acid-Schiff positivity after diastase predigestion, and in 16 cases (53%) acid mucosubstances were identified by alcian blue staining. In one of these cases the alcian blue-positive substances were abolished under predigestion by testicular hyaluronidase. Tumor cells stained positive for cytokeratin (100% of the cases), B72.3 (90%), Ber-EP4 (83%), CD 15 (57%), placental alkaline phosphatase (53%), CA 125 (43%), vimentin (23%), and carcinoembryonic antigen (10%). The survival rates at 1 year for SSPC (0%) were significantly shorter (p = 0.03) in comparison with stages III and IV ovarian carcinomas (34%). Problems of definition and differential diagnosis of SSPC are discussed.

Aged↗
PubMed1994

[Ethical and legal questions regarding the killing of animals to avoid considerable pain and suffering].

The ethical and legal problems that are connected with the killing of animals are continuously discussed. Problems with the interpretation of "reasonable reason" and the public criticism of killing to get luxury goods as well as of the methods of killing show the main points. In contrast to the killing of animals in the interest of people the euthanasia of animals to prevention of considerable, not to soothed pain and suffering is appreciated generally as reasonably and ethically justified. The ethical justification confronts with legal problems based on the conflicting position of animals in civil law. These problems are important for a practising veterinarian.

Animal Welfare↗
PubMed1993

Cytological early detection of cervical carcinoma: possibilities and limitations. Analysis of failures.

Gynecological cytology has been intensified in the district of Schwerin since 1968. The incidence of cervical carcinoma decreased from 38.9 per 100,000 women in 1969 to 19.8 in 1991 (50% of the initial figure). The mortality decreased from 25.1 to as little as 7.0 (28% of the initial figure). Because invasive cervical carcinoma is theoretically avoidable, a total of 577 new cases observed from 1980 to 1988 were investigated in respect of participation in screening and reasons for the failures. 317 (55%) of these women did not participate in the examination more than five years before diagnosis of invasive cancer. 260 (45%) of these women were examined by gynecologists once, several times (87 (67%)) or annually (173 (33%)) during a five year period prior to the diagnosis of cancer. An independent review of the smears explained the highest number of negative smears by nonobtaining of representative material and only 19% as a ministerpretation of the cytological finding. The gynecologists failed to: take smears (36 women); carry out a cytological control or histological verification (48); obtain adequate smears (116); consider clinical symptoms (22).

Adult↗
PubMed1993

[Epidemiologic studies of C. bovis and T. saginata infections in eastern and western Germany].

An investigation on the epidemiological situation of cysticercosis/taeniasis (Taenia saginata--GOEZE, 1782) showed clear differences in the proportion of cattle infected with C. bovis in the eastern and western part of Germany. Reasons for the high level of the C. bovis infection in the former GDR are a bad waste water situation and an increased intensification of agriculture (high concentration of cattle, increased irrigation).

Animals↗
PubMed1991

[Mesenchymal tumors after surgery and radiation therapy of breast carcinoma].

An account is given in this paper of 6 women aged between 41 and 70 years in whom mesenchymal tumors developed after surgery and postoperative radiotherapy for mammary carcinoma. Malignant fibrous histiocytoma developed in 2 women, five and a half or ten and a half years after primary therapy. Angiosarcoma (Stewart-Treves syndrome) was recorded from another 2 women, three and a half or ten years after primary treatment. One women exhibited a chondrosarcoma, following an interval of six and a half years. Premalignant early phase of Stewart-Treves syndrome was diagnosed, after 8 years, in a woman who was 41 years of age. The criteria for assumption of post-radiogenic secondary tumor, as demanded by Cahan et al. (1948), are discussed in some detail. Its avoidance or early detection is considered to depend on individual, stage-related therapeutic planning and long-term follow-up of patients who had undergone surgery and postoperative radiotherapy for mammary carcinoma.

Adult↗
PubMed1986

Tissue-specific expression of glucokinase: identification of the gene product in liver and pancreatic islets.

The tissue distribution of glucokinase (ATP:D-hexose 6-phosphotransferase, EC 2.7.1.1) was examined by protein blotting analysis. Antibodies raised against rat liver glucokinase recognized a single protein subunit with an apparent Mr of 56,500 on nitrocellulose blots of cytosol protein from liver, separated by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. A protein of identical electrophoretic mobility was detected by immunoblotting of cytosol protein from pancreatic islets. Hepatic glucokinase and the immunoreactive islet product bound to and were eluted from DEAE-cellulose at the same ionic strength. Glucokinase was displayed as a set of two spots with apparent pI values of 5.54 and 5.64 by immunoblotting after two-dimensional gel electrophoresis. The two isoforms appeared equally abundant in liver extract, whereas the component with a pI of 5.64 was predominant in islets. By quantitative immunoblotting, glucokinase was estimated to represent 0.1% of total cytosol protein in liver and 1/20th as much in islets. The glucokinase activity of both liver and islet cytosols was suppressed by the antibodies to hepatic glucokinase. Immunoblotting of cytosol protein from intestinal mucosa, exocrine pancreas, epididymal adipose tissue, kidney, brain, and spleen failed to reveal the glucokinase protein. Thus, significant expression of the glucokinase gene appears restricted to the liver and pancreatic islets.

Animals↗
PubMed1985

Nuclear medicine liver function tests for pregnant women and children. 1. Breath tests with 14C-methacetin and 13C-methacetin.

Stable isotopes, such as 13C, should be substituted for the long-lived radionuclide 14C in the 14C breath test when doing liver function tests in children and pregnant women. For comparison 13C, 15N-methacetin and 14C-methacetin were synthesized as suitable diagnostic agents. Methods are described for the measurement of 14C and 13C in the breath. After oral administration of labelled methacetin to healthy subjects and patients with liver diseases a good correspondence between 13C- and 14C-measurements in the same subject on the one hand, and a good discrimination between controls and patients on the other hand were shown. Findings with regard to 14C measurements in urine are discussed supporting the supposed advantage of 13C-methacetin over 14C-methacetin application.

Acetamides↗
PubMed1985

The value of cytodiagnosis in cervix cancer precursors and the latency and progression of carcinoma in situ.

The biological behaviour, the progression rate and the latency period of the carcinoma in situ of the cervix uteri are discussed. We have tried to find out this by concluding indirectly and evaluating epidemiologically our own material, and considering the literature. Between 1966 and 1982 we bioptically diagnosed 3.327 in situ and 1.653 invasive carcinomas. Among these there were 155 (9.4%) microcarcinomas. The annual average age of women with carcinomata in situ in the years 1973 to 1982 was between 35 and 40 years with tendency to younger groups. The average age of women with invasive carcinomas with the microcarcinoma excluded ranged from 51 to 59 years. The average age of 114 women with microcarcinomas during 1973 to 1982 was 47 years. The carcinoma in situ is a precursor of the invasive carcinoma in almost each case. The progression rate is approximately 30 to 50%. The period of latency from carcinoma in situ to microcarcinoma amounts to 7 to 10 years on the average, to clinically manifest invasive carcinoma 10 to 15 years. A reliable prognosis is impossible for the individual case. After the establishment of a cytological department at the Pathological Institute Schwerin in 1968 the annual number of cytological examinations has increased to 74,000 women in 1982 (approximately 40% of women over 20 years; 50% of women between 20 and 60 years). The incidence of invasive cervical carcinoma decreased from 1969 to 1982 from 38.9 to 20.7 per 100,000 (53% of the initial figure). The mortality decreased from 25.1 to as little as 9.7 per 100,000 (39%).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1984

[Chordoid sarcoma of the urinary bladder].

A case report of a chordoid sarcoma of the urinary bladder of an 81 years old man is presented. After the first description of the extraskeletal chordoid sarcoma in 1948, this is the first report of the tumor of the urinary bladder.

Aged↗