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G Mack

Publications and source records attributed to G Mack.

At least 73 records · Page 4Linked to original sources
PubMed1978

[The effects of phenylbutazone on the decrease of lithium clearance].

During the treatment of a manic depressive patient, the authors reported some lithium toxicity signs, as lithium carbonate (3 X 300 mg p.d.) and phenylbutazone suppository (3 X 250 mg/p.d.) were associated, this last medication being prescribed for a phlebitis. Lithiemia increased from .70 to 1,44 mEq/l., the lithiemia clearance falling from 10 ml to 5 ml/mn/1.73 m2) and the lithium tubular reabsorption percentage increasing from 85 to 94% (standard rates: 77.4 +/- 1.3%). In a second time, a rat experimentation corroborated these findings: phenylbutazone treatment (100 mg/kg/p.o. for five days) resulted in a lithium tubular reabsorption increase. It seems that the association of lithium carbonate with phenylbutazone should be avoided. The authors point out the risk of prescribing lithium and pyrazolic by-products as phenylbutazone, which are potentially nephrotoxic.

Animals↗
PubMed1976

[Inhibition of mouse-killing behavior by rats with taurine, GABA, and its analogues].

The injection of Gaba, of taurine or of a structural analog of GABA (n-dipropylacetate) in the olfactive bulb of "killer" Rats was found to inhibit the mouse-killing behaviour of the rat. The same effect was obtained when taurine or n-dipropylacetate (which increases GABA in the central nervous system), was injected intraperitoneally. The experiments reported here are interpreted to explain certain molecular mechanisms of muricidal behaviour.

Aggression↗
PubMed1976

Effects of acute morphine administration on the catecholamine metabolism of three strains of mice.

Inbred mouse strains exhibit differences in motor activity and brain catecholamine metabolism after acute morphine injection. The two strains C57BL/6J and Balb/cJ, which increased motor activity after morphine present also an increased noradrenaline turnover in the pons medulla, whereas no difference were found in the DBA/2J strain whose motor activity was unchanged. A correlation seems to exist between motor activity and the noradrenaline metabolism in the brain stem.

Animals↗
PubMed1973

Monoamine oxidase in rat arteries: evidence for different forms and selective localization.

1. Two forms of monoamine oxidase activity were differentiated in rat mesenteric and femoral artery by means of substrate and inhibitor specificities: one form deaminated tyramine, 5-hydroxytryptamine and noradrenaline and was highly sensitive to pargyline and clorgyline but resistant towards carbonyl reagents. This form resembled type A monoamine oxidase previously described. The other deaminated tyramine but not 5-hydroxytryptamine or noradrenaline and was inhibited by carbonyl reagents but not by clorgyline or pargyline.2. About one third of the total monoamine oxidase in homogenates of rat mesenteric artery was recovered in a 10(5)g supernatant. Both forms were partially soluble, but relatively less of the type A activity was recovered in the soluble fraction.3. Chemical sympathectomy with 6-hydroxydopamine resulted in a loss of 59% of monoamine oxidase activity in the mesenteric artery. There was a selective loss of type A activity, as revealed by the 70% decrease in 5-hydroxytryptamine deaminating ability and by the marked decrease in clorgyline sensitivity. The second monoamine oxidase species was resistant to 6-hydroxydopamine. The soluble activity was not affected by chemical sympathectomy. Most of the transmitter-specific monoamine oxidase of the arterial wall was localized within the adrenergic nerve endings. Our observations are consistent with the hypothesis that extraneuronal monoamine oxidase plays only a minor role in metabolizing noradrenaline in sympathetically innervated tissues.4. Plasma amine oxidase might originate from the arterial wall since it has similar characteristics to that found in the mesenteric artery.

Alkynes↗