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Biomedical subjects

G Madar

Publications and source records attributed to G Madar.

At least 19 recordsLinked to original sources
PubMed1990

[Varicose veins and chronic venous insufficiency--minor disorder or disease? A critical review of the literature].

The controversial question of the incidence and significance of varicoses and chronic venous insufficiency is analysed by a critical review of epidemiological studies. It is seen that many of the results which initially appear to diverge are attributable to different, in part unsatisfactory epidemiological methods; e.g. patient groups of different ages and sex, different interview and examination techniques in addition to, above all, different weighting of varicosis. Thus, studies in general practice showed that the prevalence for varicoses in women was four times that in men; CVI was, in fact, 15 times more frequent than in epidemiological studies. The different weighting of varicoses and chronic venous insufficiency may well be one of the major reasons for the absent "unité de doctrine".

Cross-Sectional Studies↗
PubMed1985

[The fate of the patient with deep vein thrombosis].

Late results in 278 consecutive patients with unilateral deep vein thrombosis treated with streptokinase or heparin/dicoumarol were analysed as to mortality rate, recurrent thrombo-embolism and incidence of postthrombotic syndrome (PTS). The five-year mortality rate was three times as high as that of the age-matched population. The overall mortality rate was 16%, more than half the patients dying of tumour, males largely of gastric or bronchial carcinoma, females of urogenital carcinoma. Thrombo-embolism had recurred in 14% of 204 patients who had been re-examined, in 9% thrombosis, in 3% pulmonary embolism, and in 2% both. A PTS without ulcer had developed in 16%, an ulcer in 8%. The PTS incidence correlated with the original extent of the thrombosis: no PTS if the thrombosis had been confined to the lower-leg axis, but 34% after four-level thrombosis. The data confirm the importance of thrombo-embolism prophylaxis, early diagnosis and subsequent treatment with anticoagulants and compression.

Adult↗
PubMed1978

[Overview: varicosis (author's transl)].

The prevalence and sociomedical importance of peripheral venous diseases and peripheral venous disorders are discussed on the basis of a prospective epidemiologic field study (Basle Study) among 4529 apparently healthy workers and clerks of the Basle pharmaceutical industry. Prevalence: Pulmonary embolism was reported in 2% phlebitis in 10%. Varicose veins were present in 56% and signs of chronic venous insufficiency in 16%, respectively. Reticular and hyphen web varices predominated. Stem varicose veins were found in 15%. The sociomedical importance of varicose veins is evaluated according to the rates of complication and treatment. A medically significant varicosity was present in 12% of this working population. Three percent presented severe alterations that already had caused complications and 9% presented changes indicating.

Adult↗
PubMed1975

Treatment of deep vein thrombosis with streptokinase.

From September 1962 to May 1972 145 patients with acute or subacute deep vein thrombosis confirmed by phlebography were treated with streptokinase. During the same period 42 patients considered unfit for thrombolytic therapy were treated with herapin and oral anticoagulants. The results, assessed by repeat phlebography, in 93 of the patients treated with streptokinase were compared with those in 42 patients treated with heparin. The age, sex, and severity of occlusion were roughly similar in both groups. Streptokinase treatment was successful in 42 per cent, partially successful in 25 per cent, and unsuccessful in 32 per cent of the 93 patients compared with none, 10 per cent, and 88 percent respectively in the 42 patients treated with heparin. Streptokinase was more effective when the thrombus was in proximal rather than calf veins. Thrombi of more than six days old were readily lysed. Plasma fibrinogen levels were below 0-8 g/1 (80 mg/100 ml) in nearly all patients successfully treated. The incidence of pulmonary embolism was no greater with streptokinase than with heparin treatment. Only prolonged follow-up would show whether thrombolytic treatment would be effective in preventing late complications of deep vein thrombosis such as chronic venous insufficiency.

Adult↗