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Biomedical subjects

G Magnusson

Publications and source records attributed to G Magnusson.

223 records · Page 13Linked to original sources
PubMedDate not supplied

Life-long endurance-trained elderly men have high aerobic power, but have similar muscle strength to non-active elderly men.

The knee extensor and plantar flexor muscle groups of elderly men (age 70-100 years, N = 15), who since adolescence had maintained an extremely high level of endurance-based physical activity (maximal oxygen uptake 41.9 +/- 4.8 mL.kg-1min-1 in subjects < 80 years, (N = 8) and 27.1 +/- 5.4 mL.kg-1min-1 in those > 80 years, N = 5), were compared in terms of maximum voluntary isometric strength and twitch contractile properties with the muscles of elderly men of a similar age who did not undertake any regular physical exercise (68-92 years, N = 18) and of young control subjects who were recreationally active (21-36 years, N = 17). No difference was observed in the maximum voluntary strength of the knee extensors (338 +/- 130 N vs 341 +/- 137 N) or plantar flexor muscle groups (106 +/- 24 Nm vs 115 +/- 46 Nm) between the endurance-trained and elderly control subjects. This was still the case when the subjects were divided into those above and below 80 years of age, or when the data were expressed relative to body weight. Both groups of elderly subjects were markedly weaker than the young control subjects. In the plantar flexors, twitch time to peak tension (TPT) was significantly (p < 0.05) prolonged in both groups of elderly subjects vs the young control subjects. In the knee extensors, however, TPT was only prolonged in the endurance-trained athletes. Half relaxation time was prolonged in the knee extensors of both groups of elderly subjects, but only prolonged in the plantar flexors of the control subjects. The data raise the question of specificity of muscle usage, and its effect on skeletal muscle function, and suggest that endurance-based physical exercise may be of little value in maintaining muscle strength and speed of contraction in old age.

Adolescent↗
PubMedDate not supplied

Shall poorly HL-A matched cadaveric kidneys be transplanted or discarded?

The study comprises 101 cadaveric kidneys transplanted in the last three years (1971-1974). Twenty-one retransplantations were included since the graft and patient survival in this group were equivalent to primary transplantations. There were 13 compatible grafts (A and B matches), 29 displaying one incompatible antigen (C match), 35 with two (D match) and 24 with 3 or 4 mismatches (E and G matches). At 9 months, there was a significantly lower graft survival in the E and G match group (33%) compared to the rest (p less than 0.01). For reasons discussed we will, however, for the first time being continue to transplant also the badly matched cadaveric kidneys.

Cadaver↗
PubMedDate not supplied

Avascular necrosis of the bone in 99 renal allograft recipients.

Avascular necrosis of bone is a serious complication associated with steroid therapy in high dose. Ninetynine patients with functioning renal allografts transplanted 1964-1973 and subjected to steroid therapy were examined with regard to this complication. Osteonecrosis developed in 8 patients afflicting 13 joints. The process was localized to the femoral head, the condyles of the femur, tibia and the head of the humerus. The symptoms became manifest 7-33 months after the first transplantation. The severity of the disorder in 3 patients did not allow rehabilitation by conservative means. The roentgenographic, scintigraphic and clinical findings are described and the orthopaedic treatment discussed.

Bone Diseases↗
PubMedDate not supplied

Gastrointestinal complications in 248 kidney transplant recipients.

In 248 kidney transplant recipients, 28 (11%) developed serious gastrointestinal complications after the transplantation. Upper gastrointestinal bleeding was the most common complication and accounted for 19 of the cases. Most of the haemorraging occurred during the first 6 months after transplantation and in conjunction with an episode of graft rejection. The mortality following upper gastrointestinal bleeding was 58%. Other serious complications encountered were lower gastrointestinal bleeding (4 cases), perforation of the colon (4 cases) and mesenteric vascular occlusion (1 case). Overall mortality was 43%.

Adult↗