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Biomedical subjects

G Mailath

Publications and source records attributed to G Mailath.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Ionomeric vitreous cement for retrograde root filling].

In an in vitro study the sealing properties of materials commonly used for retrograde filling of apicectomized teeth were investigated in extracted teeth and compared with those of ionomeric vitreous cement. Materials tested included: --Heat-sealed guttapercha; --Guttapercha + phosphate cement; --Amalgam; --Standardized ceramic pins (Ulm system); and --Ionomeric vitreous cement. Sealing was established by methylene blue perfusion. Seals produced by heat-sealed guttapercha, guttapercha + phosphate cement and non-gamma-2 amalgam were found to be inferior to those obtained with ionomeric vitreous cement and standardized aluminium oxide ceramic pins.

Dental Amalgam↗
PubMed1988

[Cloning of solid tumors in double agar (human tumor stem cell assay].

62 specimens from 37 patients with solid malignant tumours were cloned by the human tumour stem cell assay (HTSCA). The growth rate, the use of two different disaggregation methods and their influence on vitality and plating efficiency were analyzed as well as the cloning rate from different tumour regions and metastases. The growth rate was 68%, and there was a significant difference in the vitality, depending on which mode of disaggregation was used. Enzymatic disaggregation showed a higher vitality than the mechanical method, although there was no difference in plating efficiency (PE). There was a marked heterogeneity in the PE of specimens from different sites of the same tumour and lymph node metastases (variation coefficient 0.507 and 2.093 respectively). The possibilities and limitations of the HTSCA are discussed with respect to our own results and those in the literature.

Cell Division↗
PubMed1987

Tongue cancer. Sonographic assessment of tumor stage.

In an effort to improve preoperative evaluation of tumors of the tongue, a prospective study on the value of ultrasound (US) for the staging of 50 surgically proven cancers of the tongue and floor of mouth was performed. Sonography was correlated with clinical staging and surgical outcome. Real-time high-frequency transducers and an echo-free silicone interface were used. The dorsal and middle thirds of the tongue were scanned from a submental access and the tip of the tongue directly. US accurately defined tumor sizes and locations in all cases. US staged cancers correctly in all cases but one. In contrast, clinical staging was correct in only 66% of cases. Surgically relevant details, such as crossing of the midline of the tongue or infiltration of the lateral pharyngeal wall, were detected with US. The major limitations of US include the nonvisualization of the epiglottis and retropharyngeal space as well as bone infiltration.

Female↗
PubMed1986

[Realtime sonography in the diagnosis and follow-up of malignant tongue tumors. II. Detection and staging].

92 sonographic examinations performed in 62 patients were evaluated to determine the possible application of sonography in the diagnosis and follow-up of malignant tumours of the tongue. Squamous cell carcinomas were by far dominant and proved to be hypoechoic, mainly inhomogeneous and ill-defined masses. In most cases, they ranged between 2 and 4 cm. in diameter. In 50% of the lesions an infiltration of the pharynx wall was confirmed, and exulcerations were correctly detected by sonography in 75%. In preoperative determination of the size of the tumour, sonography correctly detected the size in 93% of the cases and was thus markedly superior to the clinical palpatory examination, which determined a mere 43% correctly. Sonography should be included in the pretherapeutic staging of tumours of the tongue to objectify the clinical findings. It is also adequate to document tumour behaviour during radiation.

Aged↗
PubMed1986

[Radiotherapy of carcinoma of the paranasal sinuses].

Carcinomas of the paranasal sinuses are usually advanced when diagnosed and present a therapeutic challenge. During the period between February 1970 and June 1981 44 patients were treated. 22 received postoperative irradiation, seven in combination with chemotherapy. 18 patients were treated with radiation alone, eleven with concomitant chemotherapy. Four patients received preoperative irradiation, three in combination with chemotherapy. The three-year survival is 43% and the five-year survival 33%. For those 26 patients who were irradiated pre- or postoperatively with or without concomitant chemotherapy the five-year survival is 45%. We believe the patient will be afforded the greatest opportunity for cure with the combined efforts of the radiotherapist and the surgeon. The combination of chemotherapy and radiotherapy did not provide better results but increased acute and chronic toxicity of the therapy.

Adult↗
PubMed1985

[Prognostic factors in the treatment of inoperable orofacial tumors with simultaneous radiotherapy and intra-arterial chemotherapy].

Between January 1973 and April 1982 66 evaluable patients with advanced inoperable orofacial tumours underwent intraarterial Bleomycin and Methotrexate with simultaneous radiotherapy in a prospective study. 32 patients had no previous treatment, 34 patients had initial surgery, radiotherapy and/or chemotherapy. 15 mg Bleomycin were administered through a catheter into the arteria externa carotis daily in the morning. 25 mg Methotrexate were given in the same way at night followed by 3 mg Calcium-Leucovorin i.m. every 8 hours. The cumulative dose was 300 mg Bleomycin and 500 mg Methotrexate. Four hours after the administration of Bleomycin the target volume was irradiated (single fraction 2 Gy, total dose 60 to 65 Gy). The overall response rate was 65% containing 17% complete and 48% partial remission. Destruction of the bone appeared to be the most important index at the start of the therapy. Further prognostic determinants as previous treatment, localisation of the primary tumours (maxilla and mandibula respectively oral cavity and oropharynx) and local regional lymphnode stage missed statistically significance in the survival time, may be due to a possible radiosensitizing effect of the simultaneous chemotherapy. Complete remission turned out to be the most important prognostic factor after the end of treatment. Patients responding with complete remission show a median disease free survival of 56+ months and a median survival time of 82 months. Acute reactions were reversible. Only in 14% of the patients the treatment could not be finished. Better results could be obtained by electron-affinic radiosensitizers and high LET radiation.

Antineoplastic Agents↗
PubMed1985

[The use of sonography in the diagnosis of pathological changes in the mouth floor and tongue region].

The application of real-time sonography in the area of the tongue and floor of the mouth is described. Its value is examined by a sonographic-surgical correlation of 40 examinations. In 38 cases, the sonographic findings correlated well with the clinical picture, as well as with the intraoperative and pathologic findings. Ultrasound seems to be a practicable imaging method, especially with malignant infiltration of the tongue.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Use of crestal bone for augmentation of extremely knife-edged alveolar ridges prior to implant placement: report of 3 cases.

A technique is presented for interforaminal lateral augmentation of mandibles with adequate bone height, but extremely knife-edged mandibular alveolar ridges (Class IV of Cawood and Howell's classification of residual ridges), in which the crestal portion of the knife-edged ridge is used as grafting material. Following an osteotomy and rotation of the grafts by 180 degrees, the grafts were fixed to the residual ridge below the osteotomy line by means of miniscrews. All grafts showed only mild resorption after a healing period of 3 months, and it was possible to place 4 implants in the now sufficiently wide host region.

Alveolar Bone Loss↗
PubMedDate not supplied

Examination of the damping behavior of IMZ implants.

The damping behavior of 392 IMZ implants with a diameter of 4 mm was examined by performing Periotest measurements during regular implant follow-up. The results were correlated with radiographically assessed peri-implant bone reduction. To guarantee statistical independence, only one randomly chosen implant per patient was considered in the examination. In 167 implants, the difference between the mean mandibular and maxillary Periotest values proved to be statistically significant. Age, sex, and radiographic length of the endosseous part of the abutment had no influence on the Periotest values. Assessment of the Periotest values can thus be considered an additional parameter for objective determination of IMZ implant success. However, exclusive use of the Periotest method without additional radiographic examinations does not seem to be justified.

Adult↗