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Biomedical subjects

G Marosi

Publications and source records attributed to G Marosi.

At least 19 recordsLinked to original sources
PubMed2000

[Impending paradoxical embolism].

The case history of a 49-year-old female patient is reported, who was operated on because of varicose vein in the left lower extremity. A few days after the operation serious signs of cerebrovascular insult appeared. The clinical picture and the result of an urgent transoesophageal echocardiography are described; a serpentine thrombus was found to be trapped in the patent foramen ovale. During continuous intravenous heparin treatment, the patient gradually recovered, but a residual neurological deficit could be detected on discharge from the hospital. Six days after the admission, repeated transoesophageal echocardiographic examination showed no signs of intracardiac thrombus. The clinical feature of the illness, the predisposing factors, the diagnostic and therapeutic possibilities are discussed.

Diagnosis, Differential↗
PubMed1989

[ECG repolarization disorder (QT lengthening) in organophosphate poisoning].

The authors investigated in human and in experimental organophosphate intoxication the features of the toxic ECG repolarisation disturbance, the QT lengthening and its connection with cholinesterase depression. It was concluded that this pathological electrophysiological change in human intoxication does not show close correlation with the decrease of enzyme activity and cannot be influenced by atropine. The ECG alteration can be reproduced in animal experiments, it precedes the toxicologically relevant cholinesterase depression, it is pesticide dose dependent, but it cannot be induced by cholinergic or adrenergic drugs. On the basis of all this it is supposed that in organophosphate intoxication the QT lengthening reflects a direct myocardial pesticide effect and, is independent of cholinergic mediation.

Acute Disease↗
PubMed1986

Detection and localization of ventricular preexcitation in Wolff-Parkinson-White syndrome (comparative study with body surface mapping).

21 patients with Wolff-Parkinson-White (WPW) syndrome were investigated through radionuclide imaging and body surface mapping. Ventricular preexcitation was localized by display of identical phase ventricular regions (phase display). In 79% of the cases radioisotope and body surface mapping methods have identical results for the site of preexcitation. In two patients of the control group (10 patients with Lown-Ganong-Levine (LGL) syndrome), false positive outside-of septum ventricular preexcitation was detected, i.e. an 80% specificity. It is concluded that phase display might be a suitable method in the diagnosis of WPW syndrome. The sensitivity of this method can be improved using several views.

Adult↗
PubMed1985

Dimethoate-induced toxic cardiac failure in the guinea pig.

In anaesthetized guinea-pigs treated with lethal doses of dimethoate, cardiac failure and serious ECG disturbances developed in the early phase of intoxication. The toxic cardiac phenomena appeared to be unrelated to the degree of cholinesterase inhibition, but showed a close correlation with myocardial dimethoate concentration. Cardiac failure and mortality were first observed at a critical pesticide level of about 110 micrograms/g, while a level of 221 micrograms/g resulted in death in all cases. The present investigation refers to the direct effect of the pesticide on the myocardium, independent of its anticholinesterase action.

Animals↗
PubMed1983

Clinical experiences with pipecuronium bromide.

In two groups of patients the neuromuscular and circulatory effects of pipecuronium bromide (Arduan R), a new steroid type muscle relaxant were compared with those of pancuronium during balanced anaesthesia. Pipecuronium (n = 18) was found to be about 20% more potent than pancuronium (n = 20). The 95% blocking doses were: 0.059 mg kg-1 for pipecuronium and 0.075 mg kg-1 for pancuronium; these doses provided equal intubating conditions and relaxation. The onset, clinical relaxation time (clinical duration), recovery and the reversibility of the neuromuscular effects of the two agents in equipotent doses were similar. No cardiovascular or other side effects were observed with the use of pipecuronium.

Androstane-3,17-diol↗
PubMed1982

[Importance of a persisting left vena cava superior in pacemaker therapy (author's transl)].

Basing on the description of a specific case and a review of literature, the article discusses the relationship between persisting left ven cava superior and pacemaker therapy. The article covers the technical problems caused by the vascular anomaly, the complications which can be expected, the possibilities in respect of recognising the vascular anomaly, as well as the methods for coping with the special situation prevailing in a particular case.

Aged↗
PubMed1981

[Analysis of histochemical changes caused by acute Wofatox poisoning in a model experiment].

Effect of Wofatox on the central nervous system, striated muscles and on the myocardium of rats has been studied by the aid of light- and electron microscopic histochemistry. A single intraperitoneal injection of LD50 of Wofatox resulted in a total inhibition of the activity of histochemically demonstrable acetyl-cholinesterase in the central nervous system. Each striated muscle fiber has shown different sensitivity to the inhibitor, but enzyme activity of end motor plates could not be totally inhibited. In lethal acute intoxication ultrastructural changes of the myocardiuim have shown characteristic features of cardiomyopathy.

Acute Disease↗
PubMed1980

Comparative clinical study of pipecurium bromide and pancuronium bromide.

The properties and the effects of a new steroid muscle relaxant preparation 2 beta,16 beta-bis(4'-dimethyl-1'-piperazino)-3 alpha,17 beta-diacetoxy-5 alpha-androstane dibromide (pipecurium bromide, RGH-1106, Arduan) were compared to those of pancuronium bromide in a controlled randomized clinicopharmacological study using ataranalgesic anaesthesiological technique. In 45 cases pipecurium bromide, in other 45 cases pancuronium bromide was used as long-acting muscle relaxant in anaesthesia for general surgical procedures. According to the results, pipecurium bromide is approximately 20% more potent than pancuronium bromide, it induces mechanical response characteristic for non-depolarizing muscle relaxants, and the residual neuromuscular blockade can be antagonized completely by neostigmine. There were no ECG alterations or specific serum enzyme (CPK, GOT. LDH) level changes observed. Pipecurium bromide did not influence blood pressure but in contrast to the heart rate increasing effect of pancuronium bromide, it caused mild bradycardia. On the basis of the study the drug can be used for further wide scale clinical investigations.

Androstane-3,17-diol↗