PubMed Health⌕ Search

Biomedical subjects

G Martelli

Publications and source records attributed to G Martelli.

At least 55 records · Page 3Linked to original sources
PubMed1983

[The relation between erythrocyte filterability and platelet aggregation (in vitro studies in normal subjects and those with vascular disease before and after isotonic exercise)].

The aim of this study was to evaluate the possible action in vitro of the platelets on the rheological behavior of red blood cells in healthy subjects and in patients with peripheral obliterative arterial disease before and after an isotonic exercise. Red blood cells and platelets from control subjects and from patients were tested in several ratios before and after the exercise studying the erythrocyte filterability. beta-thromboglobulin, a platelet-specific protein, was determined in vivo in all subjects before and after the exercise and in vitro as percent of increase between PPP and PRP activated, to monitor the platelet release. The results showed the interrelationship between platelet activation and rheological behavior of red blood cells.

Adult↗
PubMed1983

[The effect of lysine acetylsalicylate on hemorrheological changes induced through ischemic exertion in patients with vascular disease].

This study has been performed to evaluate the in vivo effect of acetylsalicylic acid (ASA) i.v. infusion at two different dosages: 500 and 2,000 mg on the main hemorheological parameters (blood viscosity and filtrability, hematocrit) and on beta-thromboglobulin (a platelet-specific protein) in patients with peripheral obliterative arterial disease, before and after an ischemic exercise. The results obtained before and 3 and 24 h after the drug administration induced us to think that platelet-specific substances released during the ischemic exercise can affect the hemorheological parameters and that ASA may be able to interfere with these reactions by inhibiting the platelet release.

Adult↗
PubMed1982

[Effects of therapy with a association of nifedipine and atenolol in patients with systemic arterial hypertension and angina pectoris].

16 patients suffering from hypertension and angina pectoris (class II according to the NYHA) are treated with 100 mg atenolol once daily for three weeks. A good decrease of the blood-pressure values and a clinical improvement of the anginous symptomatology are observed. The bicycle ergometer exercise test showed an increase of the effort tolerance. The addition of 30 mg nifedipine for other three weeks, decreased further on the values of the blood-pressure and of the double product. The ergometric exercise showed an increase of total work and of the maximum working capacity reached by patients. This association (atenolol + nifedipine) was particularly useful in patients who presented symptoms of intolerance toward other drugs (nitroderivate f. es.), because of less collateral effects and easy administration.

Adult↗
PubMed1982

[Effects of isometric exercise (handgrip) on the systolic times of patients with essential arterial hypertension. A polygraphic study].

The modifications of systolic times during isometric exercise (hand-grip) are evaluated in a group of patients with essential hypertension. In these patients the hand-grip showed a reduction of the PEP, ICT and LVET: the re-establishment of the basal values of the PEP, ICT and LVET, became in variable times and in different ways with regard to the modifications of the miocardial performance induced by hypertension, unlike normal patients, in whom that becomes normally during the period of recovery. Little modifications of the PEP/LVET ratio, are observed in all patients and this ratio is like that observed toward blood-pressure during exercise. Blood-pressure, like heart rate, increased suddenly during exercise and returned on the basal values during the recovery, normally both in the control group and in patients with hypertension arised recently; more slowly and incompletely in patients with hypertension arised long before. The Authors related this fact to the adjustment alterations of the blood pressure.

Adult↗
PubMed1982

[Clinical, ergometric and polygraphic evaluation of the effects of metoprolol and labetalol administration in essential arterial hypertension. Comparative study].

The clinical effects, the exercise test answer, the left ventricular function by polygraphyc test after administration at middle term of Metoprolol and Labetalol have been evaluated in 20 patients with moderate and non complicated essential hypertension. The study was a double blind cross-over between Metoprolol and Labetalol (270 mg/die per os). Both drugs induced a reduction of PAOS and PAOD. The exercise test induced in all patients a decrease of PAOS and PAOD, showing an improvement of strain tolerance. The normalization of PEP and non modification of LVET seem to confirm that the treatment with Metoprolol and with Labetalol, neither induces significant modification of left ventricular function.

Adult↗
PubMed1982

[The effects of metoprolol on systolic times in patients with systemic arterial hypertension. Polygraphic study].

10 patients with systemic essential arterial hypertension have been treated with 200 mg/die of Metoprolol. The systolic times have been valued before and after the treatment. It has been observed a reduction of the pre-ejection period simultaneously and proportionally to the reduction of the arterial pressure and the cardiac frequence. These last parameters and the indices of consumption of oxygen and heart frequence have undergone a significant decrease since the first week of therapy. The bloodless indices which express the myocardic contractility demonstrated instead not to be particularly influenced.

Adult↗
PubMed1982

[Study of the left ventricular function using a polygraphic method in patients with systemic arterial hypertension].

Systolic time intervals are evaluated by polygraphic method in a group of patients with systemic arterial hypertension. An increase of pre-expulsion period (P.E.P.) was found by relative increase of isometric contraction time (I.C.T.) in subjects with "old" hypertension; no significative differences and found in subjects with recent hypertension and in controls. The A. have attributed this alterations to a compensation mechanism of the left ventricle that extends the time of its internal pressure increase to win the resistence of excessive pressure being in aorta, that influences the after load value. According to the Authors', in absence of left ventricular insufficiency, that alteration is not accompanied by other significant mechanocardiographic modifications.

Adult↗
PubMed1980

[Evaluation of left ventricular function with polygraphic method in subjects with prior myocardial infarct. Preliminary observations].

In a group of patients with previous myocardial infarction S.T.I. are evaluated by polygraphic method. In all examined patients an increment of Pre ejection period (PEP) has been observed caused by the increase of the Deformation time (Q-S1). Increased values of SFW/RFW ratio are observed in dyastolic phase. The Authors, in absence of other meccanocardiographic alterations, have ascribed the anomaly to the alteration of the myocardial contraction because of previous necrosis.

Adult↗
PubMed1979

Rhabdoviridae. Report of the Rhabdovirus Study Group, International Committee on Taxonomy of Viruses.

The family Rhabdoviridae comprises approximately 75 viruses infecting vertebrates, invertebrates and plants. The main characteristics of the member viruses are: (i) the viruses infecting vertebrates and invertebrates are bullet-shaped and the viruses infecting plants are usually bacilliform; (ii) the viruses have particle lengths varying from 130 to 380 nm and widths varying from 60 to 95 nm; (iii) the viruses possess unit-membrane envelopes from which protrude spikes 5 to 10 nm long; (iv) the viruses have precisely coiled helical nuecleocapsids with a diameter of approx. 50 nm; (v) most of the viruses which have been studied contain 5 proteins; the prototype, vesicular stomatitis virus, contains proteins designated L (large), G (glycoprotein), N (nucleoprotein), NS (nonstructural) and M (matrix); N or NS is phosphorylated in most members which have been studied; (vi) the viruses contain single-stranded RNA which is transcribed into several messenger RNA species with sizes corresponding to the structural proteins; (vii) the nucleocapsid contains the RNA-dependent RNA polymerase and is infectious; and (viii) many of the viruses produce morphologically distinct defective-interfering (T) particles.

RNA, Viral↗
PubMedDate not supplied

Breast cancer in elderly women (> or = 70 years): which treatment?

Breast cancer is a disease that affects women >70 years of age much more frequently than other age groups. Epidemiologic data show that more than 40% of breast cancers occur in the elderly. The optimal primary treatment for elderly patients with breast cancer is controversial and ranges from tamoxifen as sole therapy to surgery. Despite the high prevalence of the disease, the elderly have been excluded from clinical trials mainly for the presence of concurrent medical conditions that adversely affect treatment strategies. Since life expectancy continues to increase in western countries, an appropriate treatment that respects quality of life needs to be determined for the elderly age group. In the light of randomised and retrospective studies carried out to date, limited surgery without axillary dissection plus adjuvant tamoxifen seems to achieve, mainly for elderly patients with early stage breast cancer, a local-regional control rate comparable to that obtained with more aggressive therapeutic strategies. The results of ongoing prospective clinical trials will show whether or not conservative surgery without axillary clearance and tamoxifen may be routinely used for elderly patients with early breast cancer.

Aged↗