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Biomedical subjects

G Marus

Publications and source records attributed to G Marus.

4 recordsLinked to original sources

Chronic atlanto-axial dislocation with spontaneous bony fusion.

A case of long standing atlanto-axial subluxation following relatively minor trauma is reported. Progressive development of pain and spastic quadriparesis led to clinical and radiological investigation at Groote Schuur Hospital which revealed a spontaneous fusion of C1 and C2 with marked compromise of the spinal cord. The possibility of a pre-existing unfused odontoid process (os odontoideum) is discussed. A brief review of the literature is presented.

Atlanto-Axial Joint↗

Malignant glioma following radiotherapy for unrelated primary tumors.

Four cases are documented where a glioma was histologically verified in the irradiation field of a previously treated malignancy of a different cell line. Radiation-induced neoplasia in the central nervous system now has been established in the induction of meningioma and sarcoma. The association between therapeutic irradiation and glioma in the reported cases lends to the evidence that a causal relation does exist. This incidence is small and does not detract from the overall benefit of irradiation as a therapeutic modality.

Adult↗

Microcystic meningiomas.

Four patients (two male and two female) underwent surgery for the removal of tumors with clinical and radiographic features typical of a meningioma. Despite an incorrect intraoperative frozen section diagnosis in two cases, the tumors were totally resected because the surgeon was convinced of the meningiomatous nature of the lesion. Subsequent histology revealed features of a microcystic meningioma and careful scrutiny of paraffin sections showed that each of the tumors contained occasional typical meningothelial cellular whorls which were a helpful diagnostic clue. Ultrastructural examination and the absence of GFAP confirmed the diagnosis. Close liaison with the neurosurgeon, on the part of the pathologist and an awareness of this unusual variant of meningioma should prevent misdiagnosis and inappropriate treatment of a potentially curable tumor.

Adult↗