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Biomedical subjects

G Mathé

Publications and source records attributed to G Mathé.

At least 613 records · Page 34Linked to original sources
PubMedDate not supplied

Identification of mammary metastatic cells in the bone marrow as a marker of a minimal residual disease and of their proliferative index as a factor of prognosis--an immunocytologic study with monoclonal antibodies.

A study of 200 patients with breast cancer at different stages was carried out. Proliferating mammary cells in bone marrow were detected using a double-staining method with monoclonal antibodies. Mammary cells were visualized with antibodies raised against human breast tissue or carcinoma. DNA-synthetising cells (S-phase) were detected on the same slide, using the monoclonal antibody antibromodeoxyuridine (BrdU), after cell incubation with BrdU. Mammary cells could be detected in the bone marrow of 60% of the studied cases. In 50% of the samples with such 'micrometastasis', a high labelling index of the carcinoma cells was found. The correlation between the presence of micrometastasis and the general prognosis at the stage of residual disease is discussed.

Antibodies, Monoclonal↗
PubMedDate not supplied

Adjuvant chemotherapy and the kinetic refractoriness of minimal residual tumors.

If Skipper's exponential growth and 'log-kill' hypothesis is replaced by one assuming an S-shaped growth curve and a growth inhibition proportional to the product of the growth fraction and the tumor volume, little growth inhibition can be achieved in minimal tumors. This 'kinetic refractoriness' may explain why minimal residual tumors cannot be eradicated by adjuvant chemotherapy.

Antineoplastic Agents↗
PubMedDate not supplied

Can neo-adjuvant chemotherapy prevent residual tumors?

MA 16/C is a spontaneous mouse mammary adenocarcinoma. It is hormone-dependent and was injected s.c. into C3H/He female mice on day 0. Tumors were excised on day 15. Neo-adjuvant treatments were applied from day 1 to day 21 for hormonotherapy and immunotherapy and on days 1, 5 and 9 for chemotherapy. Adjuvant treatments were applied from day 21 to day 42 for hormonotherapy and immunotherapy, and on days 21, 25 and 29 for chemotherapy. Mixed (neo-adjuvant and adjuvant) treatments combined the two patterns. Chemotherapy consisted of an oxalato-platinum complex of trans-l-dach (l-OHP) at a dose of 5 mg/kg i.p. Hormonotherapy consisted of the LH-RH agonist (D-Trp6) LH-RH, at a dose of 100 micrograms/kg i.p. Zinc gluconate (6mg/kg per os) and bestatin (6mg/kg per os) were administered as immunoregulators. Under present experimental conditions, surgery alone did not increase the life span. Both neo-adjuvant and adjuvant chemotherapy and neo-adjuvant hormonotherapy, however, when added to surgery, increased survival significantly (p less than 0.02-p less than 0.03).

Adenocarcinoma↗
PubMedDate not supplied

Implications of survival curve slopes on the interpretation of adjuvant therapy results.

Two mathematical models can approximate the survival curves for malignant diseases. The models identify the segments of the survival curve. Also, the hazard function of the curve and the confidence intervals of the curve could be calculated. First, we studied the survival-after-relapse curve of malignant melanoma. The curve of chemo-immunotherapy showed three segments and that for immunotherapy had two segments. The immunotherapy showed its effect in the early period of treatment. Second, the disease-free survival curves for adjuvant therapies of breast cancer were compared. In the Oncofrance trial, a combination of adriamycine, vincristine, cyclophosphamide (C) and 5-fluoro-uracil (F) (AVCF) was superior to a combination of C, methotrexate and F (CMF) in all the periods of the therapy. In Lacour's trial, poly A-poly U was more effective than the no treatment in the middle and late period. In Bonadonna's trial, CMF was superior to no treatment in the early period. Third, the survival curves for immunotherapy versus non-immunotherapy of stomach cancer were analysed. Comparison of the confidence intervals of each curve clarified that no significant difference could be found between them.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

Mitoxantrone combined with vincristine, cyclophosphamide and fluorouracil for advanced breast cancer. A study of short-term response rate.

50 patients with advanced breast cancer were treated with the combination of Mitoxantrone 10mg/m2 IV day 2, 5-Fluorouracil 400mg/m2 IV and Cyclophosphamide 300mg/m2 IV day 3, 4, 5, 6 of each monthly cycle. 49 patients are evaluable for toxicity and 47 for efficacy after three months of treatment. Hematologic toxicity was substantial and dose-limiting, with one toxic death early in the trial. Other toxicities were moderate and manageable in this short-term study. The response rate after three cycles was 53% +/- 14% with 4 complete remissions, 21 partial remissions, 16 stable disease and 6 progressions. Using the fixed response rate hypothesis of Gehan generalised by Lee and Wesley, with an expected response rate of 60% consistent with the reported response rate of advanced breast cancer to Adriamycin containing regimens, we conclude that the combination studied is not less efficient for the induction of remissions in advanced breast cancer than comparable combinations with Adriamycin. As there is now substantial experimental and clinical evidence of reduced toxicity, mainly on the cardiac muscle, of Mitoxantrone as compared to Adriamycin, we feel that the routine substitution of the latter by the former in chemotherapy for advanced breast cancer is justifiable.

Adult↗
PubMedDate not supplied

A phase II study of alternating combination chemotherapy in 55 myeloma patients. A comparison with non-alternating combination chemotherapy and treatment with a single cytostatic.

Fifty-five consecutive patients with stage II and III myeloma were treated at 7 centers with alternating combinations of 7 cytostatics and prednisolone. 30/48 evaluable patients responded to the combination chemotherapy, 10/55 patients died within 15 months, and the median survival was 40 months. No advantage could be shown over a previous non-alternating combination of two cytostatics. However, stage III patients had a significantly better survival statistically (p less than 0.05) than earlier patients from the same center given only one cytostatic.

Adult↗