Biomedical subjects
Publications and source records attributed to G Mattigk.
The knowledge of the pseudohypoparathyroidism is of great importance since the consequence of inadequate treatment may be serious. The most important features of the pseudohypoparathyroidism are the hypocalcemia and seizures. The following case concerns a patient with pseudohypoparathyroidism; the clinical symptoms and treatment of this disorder will be discussed.
The author gives a review on clinical features and therapeutic aspects of febrile seizures. The treatment with different anticonvulsants is described. Differentiation between simple and complicated febrile convulsions seem to be useful for therapeutic management.
The somatosensory evoked cortical potentials were investigated for 35 healthy children (17 boys, 18 girls) between 6 and 17. The stimulation of the N. tibialis was affected at the Malleolus medialis using surface electrodes; the derivation was likewise conducted according to the ten-twenty system using surface electrodes. Investigations carried out employing this methodology demonstrate that the SEP's of the N. tibialis from the N30 to the N70 are clearly measurable in the children. The N30, P40 and N50 could be presented with the smallest standard deviations and side differences. The latencies of N30 and P40 show significant dependencies on the height of the children. Influence of gender could be demonstrated more for the latency of the N30 in from of longer latencies in boys that in girls which were independent of body size.
The somatosensory evoked potentials represent a valuable addition to currently applied diagnostic methods in neuropediatrics. Their alterations produce diagnostic results and give clues regarding its localization. The somatosensory evoked potentials can be used as a screening-method for neuropediatric diseases.
Sixty-two patients with infantile hydrocephalus were reexamined at ages ranging from 2-19 years. Operations had been performed in 46 children. The long-term intellectual prognosis of hydrocephalus is described. Sex, age and frequency of shunt complications are not related to intelligence level. In general, hydrocephalus due to spina bifida and aquaeduct stenosis results in a better intelligence level than hydrocephalus to other reasons.
The derivation of cortical somatosensory evoked potentials permits a good local and functional diagnosis of supratentorial structures and the localisation of damage in this area. The special diagnostical relevance of early cortical somatosensory evoked potentials as a sage, non-invasive examination method in pediatric neurology is given both by these characteristics and by the fact that they cannot, in principle, be influenced by sleep or by drugs affecting the central nervous system. Somatosensory evoked cortical potentials of N. medianus were investigated for 35 children (17 boys, 18 girls) between the ages of 6 and 17, for whom there were no anamnestic or clinical indications of neurological or otological diseases. Investigations demonstrate that the SEPs of the N. medianus from the P15 up to and including the N55, is in every case clearly measurable in children from preschool age up to the end of adolescence. In the evaluation of the cortical SEPs, the P15, N20 and P25 were considered to be the components most stable and those most valuable for clinical practice. These could also be presented with the smallest standard deviations and side differences. The latencies of the P15 and N20 of the N. medianus show significant dependencies on the height of the children. The later potential components, side differences, interpeak intervals and amplitudes show no correlations with height. The SEPs of N. medianus show no dependencies on gender or on physical parameters such as weight or head circumference of the experiments. In summary it can be established that, using the procedure mentioned above, the cortical somatosensory evoked potentials in children can be described well and reproducibly and within practical narrow standard limits.
Seven vertex-positive potentials--the brainstem auditory response--can be recorded from the human scalp within 10 milliseconds of an appropriate acoustic stimulus. As the waves mainly originated in the brainstem, auditory brainstem response has been applied to the judging of brainstem-dysfunction, determining brain death and for evaluation of the development of the brainstem in children.
The author gives a review on normal neurological development in the first year of life. In the second part the author describes the special reflexes and reactions laying the foundation of the normal beginning of locomotion.
The Reye's syndrome represents one of the most acute neurologic disorders of children. The clinical symptomatology, the criteria of diagnosis and the treatment are described. The unusual clinical findings, the combination of a Reye-like Syndrome with the palsy of the cranial nerve III, by a child are discussed.
Craniosynostosis means premature closure of one or more cranial sutures. The redirection of the main growth of the brain according to the remaining open sutures results in different deformities of the skull; the intracerebral pressure may be elevated and neurological signs may be present. After reviewing the etiology, pathogenesis, classification and surgical treatment of craniosynostosis, the author describes a severe clinical complication resulting from surgical intervention.
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