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G Matz

Publications and source records attributed to G Matz.

16 recordsLinked to original sources
PubMed2005

New methods for fast on-site measurement of odorous compounds.

New methods for measurement of odorous gases, especially for aerosol-bound chemical compounds, have been developed in the Department of Measurement Technology (Technical University of Hamburg Harburg--MT-TUHH). Odorous compounds in the waste gases produced by the food industry were analysed based on high-volume aerosol sampling techniques, enrichment on solid phase micro extraction (SPE) cartridges and analytical measurement techniques using thermal desorption gas chromatography-mass spectrometry. The analysis results were compared to classic analytical procedures using adsorbence materials (Tenax) for enrichment. In comparison to aerosol sampling, analysis of Tenax samples was found to be ineffective, especially for analyzing polar semi volatile compounds. In addition, sensor arrays were also used in the study to characterize odors of different waste gases emitted by food production facilities. Measuring the odor units of the waste gas of a fat producing factory, the results of sensor-array-measurements show good correlation with results obtained with olfactometric measurements.

Chemistry Techniques, Analytical↗
PubMed2001

Phase II evaluation of paclitaxel in combination with carboplatin in advanced head and neck carcinoma.

BACKGROUND: Two-thirds of patients with squamous cell carcinomas of the head and neck (SCCHN) at diagnosis have advanced disease with projected 5-year survival rates of 30%. In those patients with distant metastatic or previously treated recurrent disease, response rate to the standard regimen of cisplatin and 5-fluorouracil is approximately 30%. The authors investigated the use of paclitaxel and carboplatin in a limited Phase II study in recurrent or metastatic SCCHN to evaluate tumor response, time to progression, survival, and toxicities of this regimen. METHODS: Patients with recurrent or metastatic SCCHN not amenable to further surgical or radiation therapy were treated with 200 mg/m(2) by 3-hour infusion of paclitaxel followed by carboplatin at an area under the concentration time curve of 6 mg/mL/minute via a 20-30-minute infusion every 3 weeks. RESULTS: Thirty-seven patients were enrolled. Ninety-five percent of patients had received prior surgery and postoperative radiotherapy. The overall response rate was 27% (95% confidence interval, 13-41%) with 1 complete and 9 PRs. Median survival of all patients was 4.9 months, and 1-year survival rate was 16%. There was a 43% response rate and 15.7-month median survival rate in patients with only distant metastatic disease and 38% response rate and a 4.5-month median survival in patients with locoregional and metastatic disease. The response rate for patients with only locoregional recurrence was 7% with a median survival of 4.8 months. Grade 3-4 myelotoxicity occurred in 24% of cycles administered. There were two treatment-related deaths due to neutropenic fever and one additional death on study may have been caused by treatment-induced thrombocytopenia. CONCLUSIONS: The combination of paclitaxel and carboplatin is significantly myelotoxic and ineffective in patients with previously treated locoregionally recurrent SCCHN, whereas it deserves further evaluation in those patients with distant metastatic disease alone. In those patients with locoregional disease, other more innovative treatments are needed.

Adult↗
PubMed1993

Is fine needle aspiration biopsy of salivary gland masses really necessary?

The use of fine needle aspirate biopsies (FNAB's) in the outpatient setting has progressively escalated, particularly in the area of head and neck pathology. An increasing percentage of these are for salivary gland masses. We present our experience with salivary gland FNAB's at our institution for four years, from 1988-1992. One thousand and twenty-two (1,022) FNAB's of superficial masses were performed by two pathologists. One hundred sixty-three (15.9%) were salivary gland biopsies. Of these 163 cases, 21 (12.9%) were normal tissue, 77 (47.2%) were inflammatory processes, 50 (30.7%) were benign tumors, and 15 (9.2%) were malignant tumors. None of the aspirates were unsatisfactory. Tissue correlation was possible in 47 (28.8%) cases. Two false negative cases (4.3%) were identified; these were a Warthin's tumor diagnosed as chronic sialoadenitis by FNAB; and a poorly differentiated squamous cell carcinoma diagnosed as adenocarcinoma by FNAB. There were no false positive cases. Overall sensitivity was 95.7% and specificity was 100%. Our experience indicates that FNAB of salivary glands is an effective screening procedure in evaluating salivary gland masses. The cytologic diagnosis may assist the clinician in allaying patients' anxieties, as well as in further collateral workup prior to definitive therapy.

Adolescent↗
PubMed1983

Oenocyte differentiation correlated with the formation of ectodermal coating in the embryo of a cockroach.

The first signs of 'embryonic membrane' deposition could be observed at the 11th/12th stage of the embryonic development, while serosal apolysis occurs, and the first signs of oenocyte differentiation could be detected at the 15th stage. When pleuropodial cuticle deposition occurs, at the 16th stage, there is a rapid increase in the number of differentiating oenocytes. At the 19th stage there are some fully differentiated oenocytics, whereas, just before the cuticulin layer of the embryonic cuticle is laid down, another wave of oenocyte differentiation could be observed. The differentiation process of oenocytes and of vertebrate cells with a rapid cell membrane biogenesis (steroid secreting cells and hepatocytes) are compared. The correlation of oenocyte differentiation with ectodermal coating deposition, with molting hormone titer and with prothoracic gland differentiation is discussed.

Animals↗
PubMed1980

Prediction of survival in head and neck cancer based on leukocyte sedimentation in Ficoll-Hypaque gradients.

A battery of immunologic tests were performed on 42 patients with recurrent cancer of the head and neck whose median survival time was 6.8 months. Two tests correlated with survival: total white blood cell (WBC) count and the percentage of lymphoid cells (%LG) in the Ficoll-Hypaque gradient separated leukocyte fraction of blood. Patients with abnormally low values of %LB had a poor prognosis, as did patients who had greater than 8000 WBC count. Of the variation in %LG, 43% was due to the differences in differential WBC counts among the patients, with the remaining variation attributed to changes in the buoyant densities of the leukocytes. These data suggest that further study of the factors effecting buoyant density of cells may be clinically useful.

Cell Count↗
PubMed1979

Late onset chronic mucocutaneous candidiasis with lymphoma and specific serum inhibitory factor.

A patient with late onset chronic mucocutaneous candidiasis developed lymphocytic lymphoma. A specific inhibitor of in vitro lymphoproliferative responses to candidal antigen was detected in her serum which persisted following clinical remission of candidiasis after combined amphotericin-B and 5-Fluorocystosine therapy. It is unclear whether the combined therapy was exclusively anticandidal, nonspecific immunostimulant or cytotoxic affecting the underlying incipient lymphoma.

Amphotericin B↗
PubMed1976

Labyrinthine anomalies in trisomy 13 mosaicism.

The temporal bone histopathology of a 2-month-old male with a bilateral cleft palate, cleft lip and polydactylia due to trisomy 13 mosaicism was studied. Anomalies in the ear involved a partial absence of the superior semicircular canal, an abnormally wide lateral semicircular canal, underdeveloped cochlear coils, an abnormally broad modiolus, an undeveloped organ of Corti and an underdeveloped basilar membrane in the basal turn of the cochlea, an unusually wide cochlear aqueduct, and deformed stapedial crura.

Adult↗
PubMed1975

Encapsulation of implanted foreign bodies by hemocytes in Locusta migratoria and Melolontha melolontha.

Sterile fragments of cellophane, cat-gut, cotton, or beef muscle implanted into the body cavity of Locusta migratoria and Melolontha melolontha are immediately surrounded by granular hemocytes which form a multi-layered capsule around each foreign body. The cytoplasm of the granular hemocytes of the outer zone of the capsule in both species shows an accumulation of fibrous material (microtubules and microfilaments). None of the implanted material appeared to be degraded.

Animals↗
PubMed1975

[Tumors in insects].

The spontaneous tumors in insects are the result of an aggregation of hemocytes. The tumors appearing in Locusta migratoria and Leucophaea after severing the gastric nerves originate from abnormal proliferation of the epithelial cells, particularly in the regenerative nidi in the midgut wall. These tumors can be transmitted by an injection of hemolymph from tumorous animals, of crushed tumor homogenates and cell-free extracts and of ribonucleic acid extracted from tumorous organs.

Animals↗
PubMedDate not supplied

Longitudinal assessment of quality of life in laryngeal cancer patients.

BACKGROUND: Although quality of life (QL) and performance status are important outcomes in head and neck (HN) cancer, there is little systematic inclusion of these parameters in treatment trials. METHODS: Rate and recovery of function were evaluated over a 6-month period in 21 laryngeal cancer patients, 7 in each of 3 treatment groups: total laryngectomy (group 1), hemilaryngectomy (group 2), and radiotherapy only (group 3). Assessment included Performance Status Scale for Head and Neck Cancer Patients (PSS-HN: Diet, Speech, and Eating in Public subscales) and the FACT-HN, a multidimensional QL measure. RESULTS: Groups differed in patterns of performance recovery over time in expected directions. Group 1 recovered most slowly, without achieving normal functioning by 6 months; most of group 2 returned to normal functioning by 3 months; group 3 showed little overall dysfunction. There was no difference in overall QL between groups or over time. Performance status was significantly correlated with the FACT head and neck subscale and somewhat with the Physical subscale. In contrast, ability to eat and/or speak was not associated with overall QL nor with any other specific QL dimension (eg, emotional or social well-being). CONCLUSIONS: Results support the sensitivity and applicability of two site-specific performance/QL measures: PSS-HN and FACT-HN. Findings also emphasize the need to employ multidimensional tools to adequately evaluate the nonmedical outcomes in head and neck patients.

Aged↗
PubMedDate not supplied

Acute vestibular paralysis in herpes zoster oticus.

A case of herpes zoster oticus is presented in which the lateral and superior semicircular canals of the labyrinth were affected unilaterally. The results of several electronystagmographic examinations are described and correlated with the patient's description of symptoms. This case study indicates that disease affecting the lateral semicircular canal is reliably detected by the conventional caloric test. However, the fact that the posterior semicircular canal remained intact could not be inferred from the results of the caloric test in this case. Also the appearance of nystagmus upon eye closure appears to have been a more sensitive index of the state of the disease process than was the caloric test.

Adult↗