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Biomedical subjects

G Mayor

Publications and source records attributed to G Mayor.

At least 19 recordsLinked to original sources
PubMed1992

[Effects of captopril on left ventricular morphology and function in essential arterial hypertension].

BACKGROUND: The presence of diastolic dysfunction in a hypertensive patient is not necessarily associated to the existence of left ventricular hypertrophy. The aim of this study was to determine whether the reduction of the left ventricular mass in hypertensive patients treated with captopril is accompanied by an improvement of the diastolic filling indexes. METHODS: Nineteen patients with essential hypertension were studied before and after one year of treatment with captopril. Different morphological indexes and diastolic function of the left ventricle were evaluated by mode M and Doppler echography. RESULTS: The indexes of left ventricular mass diminished significantly with treatment with captopril. The thickness of the ventricular walls diminished with treatment although not significantly. No significant modification was observed in the indexes of diastolic function (quotient of speed of protodiastolic filling/speed of telediastolic filling and time of deceleration of transmitral fluid during diastole) following the treatment period. CONCLUSIONS: Diminution of the left ventricular mass induced by captopril in hypertensive patients is not accompanied by an improvement in ventricular filling. It is suggested that myocardial hypertrophy is not responsible for diastolic dysfunction of arterial hypertension.

Adult↗
PubMed1992

Admission screening by thyroid function tests in an acute general care teaching hospital.

To determine the incidence of unrecognized thyroid disease among admissions to a large acute care university teaching hospital, 364 samples taken on consecutive admissions were assayed for thyroid-stimulating hormone (TSH) and free thyroxine index (FTI). Patients with abnormal test results were further evaluated by determination of antimicrosomal and antithyroglobulin antibodies, and charts were reviewed for evidence of prior diagnosis of thyroid disease, especially severe illness, drug treatment that might affect thyroid function tests, and prior diagnosis of thyroid disease. Results of subsequent thyroid function tests performed during the patient's hospitalization were correlated with the admission serum assays, and data on subsequent testing during the following 6 months were also obtained. A total of 3.9% of patients had significantly depressed TSH, and 11.1% of values were significantly elevated. A total of 11.3% of patients had significantly low FTI values, and 1% had significantly elevated values. A total of 7.4% appeared to have the euthyroid sick syndrome, 5.8% appeared to have unrecognized or undertreated primary thyroid failure, 6% had apparent subclinical hypothyroidism, 2% were thyrotoxic, and 2.8% (all women) had suppressed TSH levels for inapparent reasons. Limiting testing to patients over 49 years of age, or to women, would have missed many individuals with abnormal test results. Considering widespread availability of tests, relative costs, and value of the information obtained, it is suggested that the FTI determination would provide an appropriate screening test for patients in a population such as this entering a large, acute care general hospital.

Diagnostic Tests, Routine↗
PubMed1991

[The presence of diastolic dysfunction in hypertensive patients without left ventricular hypertrophy].

BACKGROUND: Hypertension is associated with abnormalities in the diastolic left ventricular function. The present study was performed to evaluate whether diastolic function is impaired independently from myocardial hypertrophy. METHODS: 41 patients with essential hypertension who had never received antihypertensive therapy were evaluated. All patients had normal systolic function. VE wave, or early diastolic filling wave, and VA, or late diastolic filling wave, were measured by Doppler echocardiography, and the VE/VA ratio was used as index of diastolic function. RESULTS: The VE/VA ratio was abnormally reduced in 23 patients, of which only 9 had left ventricular hypertrophy on echocardiographic criteria. The patients with a reduced ratio were older (p less than 0.01) than patients with a normal ratio. VE/VA ratio was not correlated with left ventricular mass, but it was correlated with age (r = 0.4186, p less than 0.01). CONCLUSIONS: Left ventricular diastolic function is impaired in hypertension independently from hypertrophy. The myocardial abnormalities associated with aging might be the major determinants of this functional impairment.

Adult↗
PubMed1991

[Association of cardiovascular risk factors in hypertensive patients with left ventricular hypertrophy].

The cardiovascular morbidity-mortality is higher between the patients with essential hypertension and LVH. It is due to effects over heart provoked by the abnormal increment of the myocardial mass. However, the role of others concurrent risk factors must be determined. To analyze this possibility, we studied the distribution of the main cardiovascular risk factors in a population of 50 essential hypertensive patients non treated before. They were shared in two groups: 32 patients with LVH diagnosed by echocardiography (left ventricular mass index greater than 120 g/m2) and 18 patients without LVH. The comparison between both groups showed that the patients with LVH had higher systolic arterial pressure (p less than 0.05), higher mean arterial pressure (p less than 0.05), higher alcohol (p less than 0.01) and tobacco (p less than 0.02) consumption, higher values of triglycerides (p less than 0.05) and uric acid (p less than 0.01), and higher plasma renin activity (p less than 0.05) than those observed in the group without LVH. Plasma cholesterol was also higher (increase of 11%) in patients with LVH; then, in these patients its mean value (245 +/- 12 mg/dl, M +/- SD) was over the top of the normal limit (240 mg/dl), which discriminate the risk of cardiovascular complications for this factor. The following factors: age, sex distribution, diastolic arterial pressure, sedentary life and carbohydrate intolerance, didn't present differences between the groups. These results show that hypertensive patients with LVH, as a group, have others factors of risk, different from ventricular hypertrophy, which favour the high cardiovascular morbidity-mortality of LVH group.

Adult↗
PubMed1979

[Surgery of the adrenals].

With 131 operated patients in the University Hospital of Urology in Zurich the indication for surgery in the 4 most frequent groups of adrenal disease is discussed. The preoperative localization of the tumor is exact in 96% of all cases with the serum examination in different stage of the vena cava. The appearance of hypertensive and hypotensive crises during surgery can be prevented with an adequate alpha-adrenergic blockade and volume replacement before and during the operation. In the surgery of Morbus Cushing we prefer the bilateral, dorsal incision on the 11th rib, if we haven't an unilateral adenoma. In the cases of Conn disease the removal of the whole surroundings of the adrenal gland is additionally indicated. The prognosis of the carcinoma of surrenal glands is poor, the adrenalectomy is difficult with regard to the early infiltration, the illness is seldom stopped on account of the frequent metastatic formation.

Adrenal Gland Neoplasms↗
PubMed1976

[Complications after thoraco-retroperitoneal nephrectomy (author's transl)].

We are of the opinion that for large kidney tumors in the upper region as the afflicted venous portions, the most advantageous incision is a thoraco-retro- peritoneal one. It allows the surgeon total freedom of movement and ensures reliable radical tumor-nephrectomy, as well as reconstruction possibilities in the large vessels. Of course, use of this incision is not without complications. They appear, however, not as often as opponents of this method would suppose. There are other statistics to support our convictions (4). From the check-ups of our thoraco-retroperitoneal nephrectomy patients, we are able to surmise the following: - The post operative mortality rate is not increased with this method. The cause for the mortalities are, as far as one can tell, old age and/or a generally poor condition piror to nephrectomy. - Post operative complications due to access though the thorax are very few. Not one patient had to be re-operated, punctured, or treated using suction drainage. No respiratory difficulties were observed. - Post operative complications from the wound were naturally relative to the extent of the incision. It was also here unnecessary to perform a second operation except in one case of a retroperitoneal hematoma from heparinization. This complication was not the result of this particular incision.

Follow-Up Studies↗