Effect of agonists, inverse agonists, and antagonists of benzodiazepine receptors on the firing rate of substantia nigra pars reticulata neurons.
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Animals↗
Biomedical subjects
G Mereu
Publications and source records attributed to G Mereu.
N-n-propyl-norapomorphine: an extremely potent stimulant of dopamine autoreceptors.
N-n-propyl-norapomorphine (NPA) is 10-20 times more potent than apomorphine in producing hypomotility and inhibiting both striatal and limbic dopamine (DA) synthesis and the firing rate of nigral dopaminergic cells in rats. The threshold subcutaneous doses of NPA and apomorphine to significantly inhibit motor activity or DA synthesis are 1.25 and 24 microgram/kg, respectively. The intravenous ED 50 of NPA to inhibit dopaminergic firing is 0.36 microgram/kg and that for apomorphine is 9.1 microgram/kg. The above effects of NPA, as those of apomorphine, are antagonized by haloperidol and, stereospecifically by (--) sulpiride.
Animals↗
Inhibition of nigral dopaminergic firing by N-n-propyl-norapomorphine: behavioural and biochemical correlates.
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Action Potentials↗
Repeated electroconvulsive shock prevents apomorphine-induced EEG synchronization.
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Animals↗
Apomorphine and L-DOPA lower ejaculation threshold in the male rat.
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Animals↗
Benzodiazepine-induced voraciousness in cats and inhibition of amphetamine-anorexia.
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Animals↗