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Biomedical subjects

G Meyer-Schwickerath

Publications and source records attributed to G Meyer-Schwickerath.

At least 19 recordsLinked to original sources

Tumor regression after photocoagulation of malignant melanomas of the choroid: an ultrasonographic study.

Ultrasonography was performed in 24 eyes harboring malignant melanomas of the choroid to study tumor regression after xenon-arc photocoagulation at periodic intervals after each photocoagulation session. Ophthalmoscopically, 20 (83%) eyes revealed a complete regression of the tumor after 3 months to 3 years of treatment. However, ultrasonography revealed complete tumor regression in only 13 (65%) out of these 20 eyes while the remaining 7 (35%) 9 eyes had a residual tumor prominence of 0.75-1 microsecond. 14 (70%) out of 20 tumors were completely regressed 1 year after photocoagulation treatment. Most of the eyes revealed complete disappearance of the tumor after 3-5 photocoagulation sessions. Though 4 tumors which did not respond to photocoagulation treatment were located in the central temporal retina within the vascular arcade, no statistically significant difference could be seen between tumor regression and location of the tumor. Complete tumor regression was seen in 4 out of 5 eyes after encircling coagulation alone while 16 out of 19 eyes revealed complete tumor regression after addition of direct treatment of the tumor. Photocoagulation appeared to be a useful tool in the treatment of small choroidal melanomas.

Adolescent

Giant cell astrocytoma of the retina. Clinicopathologic report of a case not associated with Bourneville's disease.

A 56-year-old man presented with a disc-based intraocular mass at the posterior pole with massive subretinal exudation. Fluorescein angiography, ultrasonography, and CAT scans did not aid final diagnosis. Four months later, the patient presented again, with massive tumor progression, total retinal detachment due to proliferative vitreoretinopathy, and rubeosis iridis. Pathologic evaluation of the enucleated globe revealed a giant cell astrocytoma of the retina.

Astrocytoma

Complications of local beta radiation of uveal melanomas.

The results of local beta ray radiation of 295 eyes containing a uveal melanoma (including 74 melanomas of the anterior choroid and ciliary body) are presented with special respect to the complications of treatment. The most frequent complications were radiation retinopathy and optic neuropathy. Complications known to occur from other radiation methods, such as dry eye syndrome, loss of cilia, and scleral necrosis, did not occur in our series. The incidence of radiation cataract, as compared to the treatment with 60Co plaques, was lower in our series. An average of 700 Gy delivered to the scleral base of the tumor was needed for uveal melanomas which could be destroyed. This radiation dose resulted in a 10% incidence of radiation retinopathy.

Eye Diseases

Healon in retinal detachment with proliferative vitreoretinopathy.

In 73 eyes, retinal detachments complicated by proliferative vitreoretinopathy (PVR) were treated by intravitreal injections of Healon, in addition to scleral buckling procedures. The number of completely reattached retinas three months postoperatively was dependent upon the grade of PVR: 50% were reattached when PVR comprised only one quadrant (Grade C-1); 30% when two to four quadrants were involved (Grade C-2, C-3 and D-1). Reattachment was not achieved in two cases of PVR with funnel-like configurations (D-2). Major complications that could be attributed to Healon did not occur. The results indicate that Healon injections, combined with scleral buckling procedures, are an encouraging approach to retinal detachments with PVR Grades C-2 through D-1.

Combined Modality Therapy

[The Annette von Droste-Hülshoff syndrome].

In the past, physicians interested in the great poetess Annette von Droste-Hülshoff argued as to whether she suffered from chronic tuberculosis or Graves' disease. We can now explain her physical appearance without any difficulty, thanks to our knowledge of the oculopathy of prematurity. Annette von Droste-Hülshoff was a premature infant delivered in the seventh or eighth month, and there is no doubt that she suffered from severe myopia and myopic exophthalmos. Moreover, she had a divergent pseudosquint, as can be seen in some portraits of her; this was very probably caused by a dragged disc or dragged retina (i.e., displacement of the macula). The increasing number of outstanding talents seen among premature infants, who now grow up thanks to the incubator, reminds us that Annette von Droste-Hülshoff's vast knowledge and her poetic genius were an expression of her prematurity, which is documented in biographies and by cryptic autobiographical evidence.

Famous Persons

[Photocoagulation in retinal branch vein occlusion (RBVO) (author's transl)].

54 cases of retinal branch vein occlusion, 19 of which received photocoagulation treatment, were reviewed to assess the value of photocoagulation in this disease. Our results suggest that the effect of photocoagulation in the treatment of macular edema is not convincing. This finding is in contrast to the main stream in literature. On the other hand the treatment's beneficial effect in destroying or preventing neovascularisations in the course of RBVO seems established and may even be enhanced with the technique described. On the basis of our results and theoretical considerations, some guidelines for the care and treatment of RBVO patients are suggested.

Edema

Report of a case resembling the 'fleck retina of Kandori' with ectodermal peculiarities and macula degeneration.

This report involves the case of a 36-year-old woman followed-up for nine years. The symptoms include unique, sharply-defined, irregular, yellow, large flecks of the retina combined with bilateral macula degeneration. The patient's rusty-red hair, enamel dysplasia, and ashen-gray skin color were also noted. It is argued that this case is very likely identical with the 'fleck retina of Kandori' and as such, the first case reported outside Japan. The literature is reviewed.

Adult

[Measurement of subretinal fluid in retinal detachment (author's transl)].

In surgery for retinal detachment, such as shortening of the eyeball, volume reducing, and indentating operations, knowledge of the volume of the subretinal fluid is important. A method based on ultrasonography was developed to measure the volume of subretinal fluid preoperatively. After establishing a topography of the fundus, the height of retinal detachment can be measured by ultrasonography at 49 defined points. The diameter of the eyeball is measured at 12 different points. From the height of retinal detachment and the diameter of the eyeball it is possible to calculate the subretinal space, which is divided into 60 segments. The total volume of subretinal fluid is calculated by adding the volumes of these 60 segments. The calculus is programmed on a computer.

Body Fluids