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Biomedical subjects

G Micoli

Publications and source records attributed to G Micoli.

At least 37 records · Page 2Linked to original sources
PubMed1981

Renal lesions in essential mixed IgG-IgM cryoglobulinemia. Study of 48 cases.

56 renal biopsies in 48 patients affected by essential mixed IgG-IgM cryoglobulinemia have been examined by light microscopy and immunofluorescence. Patients were classified in four groups: 1) minimal lesions (4 patients); 2) pure proliferative mesangial lesions (9 patients); 3) membranoproliferative glomerulonephritis (23 patients); 4)proliferative glomerulonephritis with prominent intraluminal thrombi (12 patients). In this last group large intraluminal thrombi intensely fixing anti-IgG and IgM antisera were present; unlike the preceding groups, few deposits on capillary walls were seen. These four groups differed in renal clinical syndrome at presentation: in particular, proteinuria or nephrotic syndrome was the predominant manifestation in group 3, acute nephritic syndrome in group 4. In the latter, reversal of renal failure and regression of lesions could be observed. Various morphological aspects tend to show that in this disease more than one mechanism is operating in producing renal damage, including local trapping of abnormal circulating proteins.

Cryoglobulinemia↗
PubMedDate not supplied

Diabetic nephropathy: clinical and histological study in 22 patients.

Twenty-two patients with insulin-dependent diabetes mellitus and renal involvement were submitted to renal biopsy. Mean age was 42 years; 10 were males, 12 females. The mean interval between clinical manifestation of nephropathy and biopsy was about 2 years. At the time of biopsy, 4 groups were distinguished according to clinical conditions, depending on the presence or absence of nephrotic syndrome and renal failure. Renal lesions were semiquantitatively evaluated, a separate score being considered for glomerular and vascular lesions. Immunofluorescence most frequently showed a pattern of faint linear IgG deposits along glomerular basement membranes. Severity of histological lesions and pattern of urinary abnormalities were not correlated with the duration of diabetes or the patients' age. Both glomerular and vascular lesions were correlated with the presence of renal failure, while no relationship with the pattern of urinary abnormalities was found. Fourteen patients were followed for more than one year after biopsy: 5 had normal renal function, 4 were in chronic renal insufficiency and 5 in end-stage renal failure (3 were in dialysis, 2 died). There was no correlation between the 3 above-mentioned types of evolution and glomerular histological findings. Nevertheless a higher score of vascular impairment at biopsy was observed among patients who subsequently were found to have a more unfavorable prognosis. Therefore renal biopsy, by providing information on the degree of renal vascular damage, may have some value in predicting the clinical course of diabetic nephropathy.

Adult↗
PubMedDate not supplied

[A case of desmoplastic malignant melanoma].

Desmoplastic malignant melanoma: report of a case. Authors report a case of desmoplastic malignant melanoma, a variant of the common primary cutaneous malignant melanoma in a 42 years old man, who was admitted into Hospital for metastatic node disease. Differential diagnoses on the primary, eventually discovered on the right knee, are discussed.

Adult↗
PubMedDate not supplied

[Headache as "sentinel" symptom in personnel involved in the preparation and administration of antineoplastic drugs].

The increased prevalence of neoplastic diseases observed over the last years has resulted for in more frequent operations of preparation and administration of antiblastic drugs performed by the medical personnel. In this study, we examined a group of subjects involved in the preparation of ACNU, Methotrexate, Novantrone, Vincristine, Cyclophosphamide, Carboplatinum, Mythoxantrone, in order to elucidate whether headache may represent an early symptom of exposure to these products. At the same time, we measured the degree of pollution in the air surrounding the vertical laminar flow aspiration cabinet used for drug preparation. The 66.6% of the 12 subjects studied, 9 females and 3 males, complained of headache. However, the environmental detection using high performance liquid chromatography coupled with triple quadrupole mass spectrometry (HPLC/MS/MS) gave negative results with respect to a possible environmental damage. These findings suggest that headache is the onset symptom of the toxic effect of antiblastic chemiotherapics in the medical personnel involved in drug preparation and administration.

Adult↗
PubMedDate not supplied

[Benign intraparotid schwannoma].

Benign schwannoma in the parotid gland. Authors report a case of a benign schwannoma of the parotid gland, whose correct diagnosis had been suggested after the FNAB. They check the literature for similar cases since the sixties and discuss the differential diagnoses in the cytologic specimens obtained by FNAB.

Aged↗
PubMedDate not supplied

[Intravenous leiomyomatosis. Presentation of 5 cases and a review of the literature].

Authors report five cases of intravenous leiomyomatosis, one of which had colonized the inferior vena cava and the right atrium, and make a review of the literature. The morphology of the lesions is in keeping with that previously reported. Moreover the immunostainings confirm the nature and the intravascular location of the neoplastic tissue. Authors taking into consideration the two most likely differential diagnoses afford the problem of the so-called "metastasizing leiomyoma". Eventually they agree that intravenous leiomyomatosis is an underdiagnosed entity that possibly will be more easily recognized due to the modern non-invasive diagnostic procedures.

Adult↗