Biomedical subjects

G Modica

Publications and source records attributed to G Modica.

At least 19 recordsLinked to original sources

PubMed1995

[Cross-over study on the effects of ketanserin vs enalapril in the treatment of hypertension].

The aim of the study was to compare antihypertensive efficacy and safety of ketanserin with those of enalapril in the treatment of hypertension. The study design was controlled, cross-over, with randomized sequences. The efficacy was evaluated from data of 19 (9 males, 10 females) mean age 59.5 +/- 10.1 years, weight kg 68 +/- 12.1 with hypertension lasting over 5 years. Posology was ketanserin 20-40 mg bid, and enalapril 10-20 mg bid; both for three weeks. The efficacy was good with both treatments and the effects similar. In fact, at the end of the treatment with ketanserin, supine SBP was decreased 10 +/- 20 and DBP 5 +/- 10 mmHg, standing SBP was reduced 15 +/- 19 and DBP 7 +/- 15 mmHg. With enalapril supine SBP decreased 25 +/- 16 and DBP 10 +/- 13 mmHg, standing SBP was reduced 16 +/- 19 and DBP 8 +/- 18 mmHg. Changes of heart rate by either treatment were of no clinical importance. The safety of treatment with ketanserin was excellent, while 14.3% of the patients treated with enalapril had undesirable effects.

Aged↗

PubMed1993

[Diastolic flow in the left ventricle of healthy subjects: a study using processing of intracardiac color-Doppler maps].

UNLABELLED: Aim of the study was to evaluate the left ventricular (LV) diastolic flow propagation. Ten healthy subjects (28 +/- 6 years) were examined. Two-dimensional echocardiography and color-Doppler at mitral valve were performed. A cine-loop was transferred on-line to a color image processor. Selected digitized images were stored on microdisk. LV end-diastolic, end-systolic and early filling (EF) volumes were measured. Doppler measurements across the mitral valve were obtained: peak E, peak A, E/A, the integral (VTI) of E and A, acceleration and filling time. Extension of color and time base to apex, time of EF and atrial filling (AF) were obtained by M-color, along the base-apex axis. On frames of EF and AF of 2D-color, diastolic maps were processed: surface area and pixel velocity, mean (mv) and peak (pv), were obtained of the entire color area and of 4 selected areas, 2 mm wide: 1 along the annulus-apex axis (LAx), and 3 transverse, planes, at the annulus, at papillary (1/3) and at the apex (2/3 of LAx). Three-dimensional plot and velocity distribution were obtained. Values of pixel of the entire color area were stored on microdisk and processed using a Macintosh PC. For each transverse section, 1 pixel wide, mv and pv were obtained, and data were referred to normalized axis and the mean was calculated. RESULTS: end-diastolic volume index (EDVI): 66 +/- 7, end-systolic volume index (ESVI): 26 +/- 5 ml.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1991

Use of BICAP in a case of colon angiodysplasia.

This paper reports on a case of colonic bleeding from an angiodysplastic lesion of the ascending colon in a 71-year-old diabetic woman, resulting in severe anemia in the patient, who was treated using the BICAP electrocoagulation system. The present report includes a description of this technique, which involves the use of a 7-F hemostatic probe connected to a 25-W BICAP source.

Aged↗

PubMed1990

[Pathophysiologic classification of heart failure: contribution of echocardiography].

Aim of the study was to examine the role of echocardiography to classify patients with heart failure. Fifty-seven subjects (32 dilated cardiomyopathy (DCM), 9 aortic regurgitation (AR), 16 hypertensives (HT)--4 in Class (CI) NYHA I, 24 II, 15 III, 14 IV--were studied by M-2D echo. Eighty-seven normals (N) were the control group; 11 were controlled after clinical improvement (3.4 +/- 3.8 months); 11 after worsening (12 +/- 17). We have evaluated: left ventricular diastolic dimension (LVIDd), wall thickness/radius ratio (H/R), diastolic (D) and systolic volume (S Vol), ejection fraction (EF), systolic arterial pressure/end-systolic volume ratio (P/V), and stress. LVIDd and stress were increased in all groups; H/R reduced, except in HT and in Cl I; EF and P/V reduced except in Cl I. Between I and II LVIDd was different; between II and III all parameters were different, between III and IV only EF and P/V. According to regression S-D Vol, EF-P/V and EF-stress we identify the reduction of EF and the related mechanisms, ie reduced contractility or increased afterload. Thus, according to P/V and stress, we classify the patients in 4 pathopysiologic classes: 1 and 2 with P/V within 2 SD N: 1 with stress within 2SD N, EF and H/R normal; 2 with stress greater than +2SD, H/R normal and EF reduced; 3 and 4 with P/C less than -2 SD N: 3 with normal, 4 with stress greater than +2 SD. In the 1 and 2, 1 out 14 is in III Cl NYHA, none in IV; in 3,6 out 8 are in II, in 4, 9 out 35 are in Cl less than III. In the follow-up, in 8 of the improved patients, EF and P/V were increased and stress reduced; in 3, EF was reduced. In 8 of the worsened, EF and P/V were reduced, LVIDd and stress increased; in 3 EF and LVIDd were increased, P/V reduced. This study demonstrates discordance between Cl NYHA and echo, and how classification of NYHA does not give information about the several components of heart failure. However LVID and EF are not sufficient. By a correlation of echo-parameters of contractility, afterload and pump performance, we may suggest a classification of heart failure in pathophysiologic classes.

Adolescent↗

PubMed1989

[Screening for liver metastases of colorectal carcinoma by the routine use of intraoperative echography].

The detection and distribution of liver metastases from colorectal carcinoma is an important problem for the therapeutic approach and prognosis. In this study we evaluated the diagnostic accuracy and technical utility of intraoperative ultrasonography (I.O.U.) in the treatment for liver metastases from colorectal carcinoma. I.O.U. has been routine performed in 70 patients. 13 metastatic lesions have been diagnosed in 10/70 patients with colorectal carcinoma (14.3%). Only 6 of 13 lesions (sensitivity of 46.1%) have been diagnosed preoperatively and/or by surgical exploration. Instead 7 small intrahepatic metastatic lesions (53.9%) have been diagnosed exclusively by I.O.U. It has not been possible to detect this lesions by surgical exploration; the size of these metastatic tumor ranged from 0.4 x 0.6 to 1.2 x 1.6 cm. I.O.U. has been useful for its high sensitivity, for the study of anatomic relation between metastatic lesions and vascular and biliary hepatic structure (good guidance for surgical hepatic resection) and for the possibility of performing deep ultrasound guided biopsies of hepatic lesions.

Carcinoma↗

PubMed1988