Vasodilator effect of intraarterial Mydocalm in dog.
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Biomedical subjects
Publications and source records attributed to G Molnár.
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Depressive syndrome was investigated in 132 psychiatric and neurologic patients by Zung's self-rating depression scale. The dexamethasone suppression test (DST) was carried out in 62 patients. Visual evoked potentials (VEP) (stimulation with flash (F-VEP) and pattern (P-VEP)), serum levels of LH, FSH, prolactin, ACTH, estradiol and cortisol were measured in 15 female patients between 85 and 94 years of age. Abnormal DST results indicated depression rather than dementia. P-VEP latencies correlated with cognitive symptoms, while F-VEP latencies correlated with affective symptoms. Gonadotropin levels were lowered in senility in comparison with the climacteric period of life. Depressive, anxious, cognitive, anorexic, sexual and disturbed diurnal mood changes syndromes could be separated by factor analysis. The severity of the cognitive depressive syndrome correlated negatively with estradiol serum levels. The total scores of Zung's self-rating depression scales correlated positively with ACTH and negatively with FSH serum levels.
In CSF and serum of 24 fertile (34.9 +/- 12.2 years) and 15 postmenopausal (58.9 +/- 6.9 years) female patients with non-inflammatory neurologic diseases, LH, FSH, ACTH, prolactin (Prol), estradiol (E), progesterone (P), testosterone (T), and cortisol (C) levels were determined by RIA. In postmenopause, serum levels of FSH and LH had 8- and 6-fold increases in comparison to those in reproductive age. In postmenopause, serum levels of E, P, ACTH and Prol had 8-, 5-, 3- and 2-fold decreases. Serum levels of T and C remained statistically unchanged during the whole life span. In postmenopause, CSF levels of FSH and LH had 3- and 2-fold increases, while E, P, Prol, ACTH CSF levels remained statistically unchanged compared to those in reproductive age (CSF-C levels were under the test sensitivities). CSF/serum ratio of FSH had a 4-fold decrease while that of E had a 4-fold increase in the postmenopause. CSF and serum levels of estradiol and ACTH as well as the logarithmic values of FSH, Prol and P concentrations correlated significantly regarding the whole reproductive postmenopausal life span, however, the CSF-blood barrier seemed to protect the brain from the effects of peripheral estradiol-progesterone deficiencies.