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Biomedical subjects

G Monfrecola

Publications and source records attributed to G Monfrecola.

35 records · Page 2Linked to original sources
PubMed1994

Dose-dependent visible effect on mice Langerhans cell membrane markers.

Ultraviolet B and psoralen plus UVA treatment induce antigenic and enzymatic changes in Langerhans cells (LC). The aim of this study was to investigate the visible (VIS) effect on mice LC surface markers. As visible source, a slide projector equipped with a 150-W tungsten lamp, emitting between 400 and 740 nm (maximum at 580 nm) was used. Mice (BALB/c and C3H) were divided into groups, each irradiated with visible single fixed doses (ranging from 10 to 1000 J/cm2). The mice backs were shaved before irradiation. Skin biopsies obtained immediately after irradiation were processed for immunofluorescence and electron microscopy. Immunofluorescent studies showed: 1) a complete depletion of LC membrane markers at a dose of 700 J/cm2; 2) no effect at visible doses ranging between 0 and 75 J/cm2; 3) a dose-dependent effect with doses between 100 and 700 J/cm2. Electron microscopy revealed no cellular damage of LC at the visible doses administered.

Animals↗
PubMed1992

Effect of psoralen and ultraviolet A on platelet functioning: an in vitro and in vivo study.

We investigated possible alterations induced by psoralen and ultraviolet A radiation (PUVA) on platelet function both in vitro and in vivo. In vitro, using conventional aggregometry and adenosine diphosphate (ADP), collagen, ristocetin and arachidonic acid as aggregating agents, platelet aggregation was determined on platelet-rich plasma (PRP) from normal subjects at basal conditions and following the addition of increasing concentrations of 8-methoxypsoralen (8-MOP) with and without exposure to ultraviolet A (UVA) light (5 J/cm2) and compared with UVA light exposure alone. At basal conditions and following exposure to UVA light alone, no changes in the normal platelet aggregation patterns were observed. Exposure to UVA light of PRP containing 8-MOP also demonstrated no abnormality in the platelet aggregation patterns at 8-MOP concentrations of 200 ng/ml. However, abnormal platelet aggregation as a response to ADP and collagen was observed at higher concentrations of 8-MOP, which was augmented upon exposure to UVA light. In vivo, platelet aggregometry was performed on PRP from 4 patients submitted to PUVA treatment at basal conditions, 2.5 h after oral ingestion of 8-MOP (0.6-0.8 mg/kg) and after 4 PUVA sessions. No patient showed modification of the platelet aggregation profile after either 8-MOP ingestion or PUVA treatment. Our study shows that 8-MOP at high concentrations in vitro impairs platelet aggregation by ADP and collagen augmented by UVA light exposure, but PUVA therapy causes no detectable abnormality in platelet function in vivo.

Adenosine Diphosphate↗
PubMed1987

Treatment of subcorneal pustulosis by etretinate.

A 69-year-old man with sulfone-resistant subcorneal pustular dermatosis was successfully treated by etretinate, 1 mg/kg body weight for 5 days, followed by 0.75 mg/kg body weight for 2 months. This confirms the possible usefulness of systemic retinoids in nonpsoriatic pustulosis.

Aged↗
PubMed1986

Erythema gyratum perstans: association with a familial neurologic disease.

Two members of the same family with erythema gyratum perstans and hypertrophic neuritis are reported. The dermatosis could be an expression of localization of neuritis to nerva vasorum with abnormal neurovascular response of cutaneous small vessels to normal stimuli with active erythema followed by cyanosis.

Adolescent↗
PubMed1985

Lichen amyloidosus: a new therapeutic approach.

The result of topical treatment by dimethyl sulphoxide (DMSO) in a patient with lichen amyloidosus is reported. Itching improved within five days of therapy. Remarkable flattening of the papules was obtained within two weeks. The clinical result was confirmed by histological examination which revealed partially disappearance of amyloid deposits.

Administration, Topical↗
PubMed1984

Inadequate effect of helium-neon laser on venous leg ulcers.

A study to determine whether laser radiation of low-power photon density would really affect the healing of venous leg ulcers in man was performed. The ulcers were irradiated 6 d per wk with a helium-neon laser (wavelength 632.8 nm). Energy densities of 1 J/cm2 (16 patients) and 4 J/cm2 (17 patients) were administered daily. The control group (28 patients) received only antiseptic local compresses as treatment. No statistically significant difference between the laser-treated group and the control group was found. It was concluded that helium-neon laser radiation has no advantages over standard local treatments, at least with the dosage schedules and protocols employed.

Adult↗
PubMed1983

Superoxide dismutase activity in the skin of rats irradiated by He-Ne laser.

The activity of the enzyme superoxide dismutase has been measured in the skin of rats irradiated by a low-power He-Ne laser. The irradiation was performed at the doses of 4, 8 and 20 J/cm2 in a single or repeated treatment. The increase in activity of superoxide dismutase in the skin of irradiated animals was not statistically significant.

Animals↗