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Biomedical subjects

G Monnier

Publications and source records attributed to G Monnier.

54 records · Page 3Linked to original sources

[Nerve regeneration through a venous graft in the rat. Preliminary results].

An experimental study of nerve regeneration in rats was realized after sectioning 8 mm of the sciatic nerve and interpositioning a vein-graft to replace the portion of nerve which has been removed. The vein-graft was taken at the neck level, far away from the point of suture between vein and nerve, a procedure which seems to prevent the problems of scabbing. A histological and electrophysiological analysis was carried out on 16 grafts, over periods ranging from 4 weeks to 4 months. The nerve and venous dissections were realized under a stereoscopic microscope. A certain degree of amyotrophy appeared in the external-posterior region of the thigh, directly related to the muscular dissection and the partial paralysis caused by the section of the common peroneal nerve. The electrophysiological recordings in vivo provide proof of nerve regeneration but reveal the absence of any correlation between the time of recovery and the time of induction. Examination under the light microscope confirms the regeneration of the nerve inside of the vein-graft, with an augmentation of myelin sheaths, which increase with time both in number and in thickness. The vein-wall acts as a guide but the passage of a few nervous filaments outside of the graft itself is observed. Examination under the electron microscope furnishes important information on myelin sheaths. The results are of excellent quality, but to better appreciate and evaluate them, we envisage a further study, this time to be carried out on another animal species.

Animals↗

[Eaton-Lambert syndrome associated with multiple myeloma: resolution of the neuromuscular block after chemotherapy].

The Eaton Lambert syndrome is a myasthenic disorder often associated with small-cell carcinoma of the lung. In some instances, no neoplasm is demonstrated and the Eaton Lambert syndrome is isolated. This syndrome may also be associated with autoimmune diseases. The authors describe a case of Eaton Lambert syndrome in a patient with multiple myeloma that resolved after chemotherapy. The authors connect this case to evidence previously reported in the medical literature in favor of an autoimmune origin to the neuromuscular block. Considering this etiopathogenic hypothesis, immunosuppressive therapy should be attempted in these patients.

Female↗

[Separation of pygopagous Siamese twins].

The successful separation of pygopagous twins is described. The sacrum formed a common canal since S 1 to coccyx with two medullary cords side to side and diastematomyelia with, at this level, two dural sacks. In each baby there was small atrophy in one lower limb. There were two opposite vulvovaginal ducts and two recto-perineal fistules.

Anesthesia, General↗

Calcified remnants of the notochord in the roof of the nasopharynx.

Seven cases of calcification in the roof of the nasopharynx are reported. These calcifications situated in the midline opposite the pharyngeal bursa, were associated in four patients with a neural or osseous defect of the craniocervical junction. The authors estimate the frequency of this asymptomatic calcification to be about 0.1%. This finding is thought to be a calcified remnant of the notochord.

Brain↗