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Biomedical subjects

G Morduchowicz

Publications and source records attributed to G Morduchowicz.

25 records · Page 2Linked to original sources
PubMed1986

Overestimation of blood pressure in the elderly.

The blood pressure (BP) of 24 elderly (mean age +/- SD 73 +/- 5 years) and 10 young (35 +/- 11 years) hypertensive patients was measured indirectly by the cuff-mercury sphygmomanometer and directly by intra-arterial recording. The differences between indirect and direct BP (delta BP) recordings were significant (P less than 0.05) for both systolic BP (delta SBP +/- SD 16.55 +/- 15.91 mm Hg) and diastolic BP (delta DBP, 6.97 +/- 9.38 mm Hg) in the elderly group but not in the young group (delta SBP, +/- 2.50 +/- 9.70 mm Hg, delta DBP, +/- -0.03 +/- 6.55 mm Hg). The use of the cuff-mercury method may overestimate systolic and diastolic BP in elderly hypertensive patients.

Aged↗
PubMed1985

Infections in renal transplant recipients in Israel.

A 5-year retrospective survey of infections following 258 renal transplants in 233 patients is reported from a large medical center in Israel. The most common sites of infection were the urinary tract, the surgical incision, and the lung. We recorded 157 episodes of bacteriuria, 75% during the first month following transplantation. In 24 patients, 25 episodes of bacteremia were documented, with gram-negative bacteria being the most commonly involved organism. Pneumonia was diagnosed in 36 patients and was associated with relatively high mortality. Cytomegalovirus was the most common single organism responsible for infection. Fatal rhinocerebral mucormycosis was observed in three patients and was the most common invasive fungal infection. Other serious opportunistic infections were seen only rarely. Infectious diseases were the most frequent cause of death (51.1%) among these patients.

Adolescent↗
PubMed1985

Deterioration in renal function in patients with chronic renal failure after treatment with captopril.

Acute reversible renal failure has been reported in patients receiving captopril, especially those with unilateral or bilateral renal artery stenosis. Two patients with advanced renal disease presented with an acute deterioration in renal function after the introduction of captopril treatment. In both instances this deterioration was irreversible. Captopril should be used with caution in patients with advanced renal disease.

Aged↗
PubMedDate not supplied

Transfusion reactions due to bacterial contamination of blood and blood products.

Bacterial infections transmitted by blood or blood products, although rare, remain a serious threat to the recipient of a transfusion. We report on five cases of adverse reactions due to bacterial contamination of blood products, and we review 76 similar cases reported in the English-language literature. Most cases (70%) have been reported from the United States. Various sources of contamination have been suggested, including infection in the donor and invasion of the blood product during the process of collection, preparation, and storage. Frequent clinical manifestations are fever (80%), chills (53%), hypotension (37%), and nausea or vomiting (26%). The overall mortality is 35% (28 of 81 patients). In 38 patients (47%) the adverse reactions have appeared during transfusion; in the others the interval between completion of the transfusion and appearance of symptoms has ranged from 15 minutes to 17 days. A wide spectrum of bacteria have been implicated as causes of adverse reactions, with Pseudomonas species involved in 28% of episodes. Many such reactions are probably misdiagnosed or overlooked, the result being underestimation of the extent of the problem.

Adult↗
PubMedDate not supplied

Rhinocerebral mucormycosis in renal transplant recipients: report of three cases and review of the literature.

Mucormycosis is an opportunistic infection caused by fungi of the order Mucorales. The commonest clinical form is rhinocerebral mucormycosis, which has been described as characteristically complicating diabetes mellitus and leukemia. Three patients with rhinocerebral mucormycosis complicating renal transplantation are described, and 11 additional cases recorded in the English-language medical literature are reviewed. The mean age of the 14 patients was 36 years, and the ratio of males to females was 1.8:1. Diabetes mellitus was present in only five patients, and polycystic kidney was the most common underlying renal disease. Most kidney grafts were obtained from cadavers. Eight patients had evidence of graft rejection, and the majority had been receiving corticosteroids and azathioprine. The initial manifestations of infections became evident two days to four years after transplantation (median, two months). Facial swelling, tissue necrosis, and cranial nerve involvement were common. Seven of 14 cases occurred in Israel, a finding suggesting the intervention of local factors. Despite antifungal and/or surgical therapy, nine patients died as a consequence of the infection days to months after diagnosis. Although a rare complication, rhinocerebral mucormycosis remains a serious threat to the kidney transplant recipient.

Adult↗