[Nifedipine and beta blockers: a potentially dangerous association?].
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Biomedical subjects
Publications and source records attributed to G Motté.
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One or several episodes of bitachycardia (a simultaneous ventricular tachycardia and atrial tachycardia or fibrillation) were observed in 13 patients. An oesophageal or right atrial endocavitary recording is usually necessary to show the atrioventricular dissociation: even then the diagnosis may be difficult in cases of isorhythmic dissociation or when the ventricular tachycardia is irregular. In 5 cases the double tachycardia appeared to be coincidental. In 7 patients the ventricular tachycardia seemed to be dependant on the atrial tachycardia and could be initiated by a simple spontaneous atrial extrasystole in 3 cases. In one patient the ventricular tachycardia, after a phase of retrograde conduction to the atria, initiated the atrial arrhythmia. The therapeutic indications depend in part on the eventual relationship between the two arrhythmias.
A 25 year old patient presented with several types of paroxysmal tachycardia. Analysis of the recordings and the results of endocavitary electrophysiological investigation suggest the presence of nodoventricular and atrio-ventricular fibres. These two accessory pathways were latent in sinus rhythm but formed part of reentry loops. The reciprocating rhythms used the Kent bundle in the retrograde direction, and either the normal nodo-hisian or the Mahaim fibres in the anterograde direction. Simple echos ascending by the nodo-hisian pathway and descending by the nodo-ventricular pathway were also observed. The patient died of an unassociated cause and a pathological examination of the heart was performed. This confirmed the presence of a left posterior paraseptal Kent bundle and the presence of fibres relaying the inferior part of the atrioventricular node to the septal ventricular myocardium, this being made possible by a dehiscence of the central fibrous body.
In a series of 48 patients undergoing electrophysiological investigation for attacks of reciprocating tachycardia related to concealed or overt Wolff-Parkinson-White syndrome in sinus rhythm, 4 patients were found to have duality of nodal conduction. This association was responsible for several tachycardia circuits: in 2 patients the activation passed constantly retrogradely through the accessory pathway and then either through the slow nodal pathway or the rapid nodal pathway in the anterograde direction. In the other two patients, in addition to classical orthodromic tachycardia, purely intranodal reciprocating rhythms giving rise to sustained tachycardia in one case and to simple echos in the other, were observed.
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The cardiac output (Qc), indices of left ventricular function in the isovolumic period (dp/dt/Pt), max, and during the ejection period (EF, VCF), the end diastolic and end systolic ventricular volumes, the speed of ventricular filing, the module of elasticity of the ventricular chamber (kp) and the end systolic pressure-volume relationships were measured in 20 patients (11 normal in group I and 9 with and apparently primary cardiomyopathy in group II) at rest and during progressively rapid atrial pacing. The Qc was lower and the indices of left ventricular function in the isovolumic and ejectional phases, the end systolic pressure-volume relationship and speeds of ventricular filling were decreased in group II: kp was the same in both groups of patients. At progressively higher heart rates the cardiac output slightly in both groups, the systolic volume decreased, (dp/dt/Pt) max increased, the ejection fraction and VCF were unaltered. The speeds of filling and kp were unchanged. The end systolic pressure-volume relationship increased. In group I the reduction in systolic volume seemed to be related to a greater reduction in the end diastolic volume than in the end systolic volume. In group II, the reduction of the systolic volume was related only to a reduction of the end diastolic volume.
In a patient with spells of paroxysmal supraventricular tachycardia of two types, the stimulation tests demonstrated a dual intranodal conduction responsible sometimes for "usual" reciprocal rhythms (slow anterograde pathway and rapid retrograde pathway), sometimes for "reversed" reciprocal rhythms (rapid anterograde pathway and slow retrograde pathway). The latter contrasted with the lack of discontinuity of the retrograde nodal function curve (V1-V2 versus A1-A2).
A case is reported in which, contrary to the unusual finding, conduction was slower in an accessory pathway than in the node-His pathway. Only when this latter became blocked (in the trunk of the bundle of His) following on the longest refractory period, was a pre-excitation syndrome unmasked related to the right nodo-ventricular fibres (the fibres of Mahaim).
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In this study of 61 patients (group I: 37 patients with no signs of cardiac failure, group II: 24 patients with signs of cardiac failure), a comparison is made between the indices of left ventricular performance obtained during the isovolumic phase dp/dt/Pt max of the left ventricle (5F Millar micromanometer) and in the ejection phase (ejection fraction, mean speed of fibre contraction, corrected mean systolic ejection speed (left ventricular cineanigiography) and maximal acceleration of the aortic blood flow (electromagnetic velocimeter). Calculations were also made of the modulus of elasticity (Ep) and the characteristic impedance of the ascending aorta (Zo) in every patient. The results show that, for group I patients the correlation between the indices in the isovolumic and ejection phases is improved by taking Zo into account. This result is not true for group II cases except with respect to the acceleration of aortic blood flow. An analysis has been made of the hypotheses and the discrepancies.
The authors report a case of chronic second degree atrio-ventricular block with permanent right bundle branch block. Intracavitary electrophysiological recordings allowed them to delimit the refractory period of the left branch, which was affected by a block during phase 3 but also during phase 4. They showed that there was possible conduction by the right branch during the extremely fine time limits of a supernormal period; using an atrial stimulation rate of 150/mn, it is therefore possible to obtain 1/1 conduction in the presence of a left bundle branch block.
Five cases of chronic paroxysmal atrio-ventricular block are reported, being unusual in the siting of the conduction defect within the trunk of the bundle of His, and in the "paradoxical" mode of onset of the block. The ventriculograms which were carried out, and the escapes, were of normal duration in four cases and the intracavitary recordings showed a double His potential in all patients. In one case, the block during phase 4 seemed to occur at the height of the trunkal Wenkebach periods, and in another it could be brought on by manipulation of the vagus. In all five cases, a favorable conduction zone could be calculated, the block to the P waves in phase 4 occuring in an arithmetical fashion after a critical lengthening of the PR interval. The return to sinus rhythm was always related to an escape (or to an electrically induced ventricular complex), but the explanation of the initial capture on electrophysiological grounds is obscure.
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The authors have studied the bathmotropic and dromotropic effects of intravenous injection of 100 mg of disopyramide, the therapeutic dose being 1 to 2 mg/kg. Out of the 28 severe arrhythmias studied, it was the ventricular extrasystoles which benefited most from treatment (79% completely successful, while there was a lesser degree of success in treating the ventricular tachycardias (35% completely successful, 30% partially successful). The negative dromotropic effect of injected disopyramide on sub-nodal conduction was studied by an endocavitary technique in 10 patients presenting with a spontaneous onset of disordered intracardiac conduction; the effects were moderate. With the exception of 4 cases who sustained complications involving rhythm and haemodynamics, the clinical and cardiovascular tolerance of patients to the drug appeared to be satisfactory.
The static elasticity (Ep) (Peterson) and the characteristic impedance of the aorta (Zo) (Mac Donald) were evaluated by the simultaneous measurement of the pressure and diameter of the ascending aorta in 30 patients: 18 subjects were free from any aortic pathology (Group I), subjects had persistant arterial hypertension (Groupe II), and 3 subjects had aortic incompetence (Group III). In the group I patients, Ep increased significantly with age, and with the aortic pressure and diameter. In groupe II, Ep increased significantly only with aortic pressure. A narrow correlation was found between the characteristic impedance of the ascending aorta and the systolic ejection resistance, except in those patients with aortic incompetence, in whom it seems that Zo is a better measure of ejection resistance. In the group I patients, impedance increased significantly with age. No significant difference was found in the characteristic impedence between patients of groups I and II, the aortic diameter being greater in the latter group.
The authors have made a further study of the case notes of 49 patients who were followed up for several years with isolated ventricular tachycardia occurring in a heart which was otherwise healthy; such tachycardias are also called essential or idiopathic. First they define the criteria necessary for the diagnosis of essential ventricular tachycardia: -- an arbitrary age criterion (less than 45 years in men and 50 years in women) which seeks to exclude the so-called "arterial" ventricular tachycardias; -- a follow-up period of supervision of more than two years, which excludes certain primary cardiomyopathies whose presenting feature is a series of attacks of ventricular tachycardia. They then attempt to classify the ventricular tchycardias into four types, according to their clinical features and the electrocardiographic tracings at rest and on exercise, and to predict the prognosis. The most frequently encountered and benign type was the classical ventricular tachycardia of Bouveret.
The authors studied 35 cases of Bouveret type paroxysmal tachycardia with normal baseline ECB, without any signs of Wolff-Parkinson-White syndrome. In more than half the patients, it seems that it may be stated that the paroxysmal tachycardia is related not to a reciprocal intranodal rhythm, as is said classically, but to a reciprocal rhythm using in the anterograde direction the normal pathways and in a retrograde direction a direct atrio-ventricular bundle in which only retrograde conduction is possible. This explains the absence of any patent preexcitation pattern on tracings in sinus rhythm. The authors particularly stress the value of a sign recorded at the onset of an attack of tachycardia: transient slowing of the rate of the tachycardia when functional bundle branch block is present can only be explained by the existence of a latent preexcitation bundle on the side of the "slowing bundle branch block".