PubMed Health⌕ Search

Biomedical subjects

G N Aagaard

Publications and source records attributed to G N Aagaard.

At least 19 recordsLinked to original sources
PubMed1992

Level of blood pressure and risk of myocardial infarction among treated hypertensive patients.

To examine the association between the level of treated blood pressure and the incidence of myocardial infarction, we conducted a population-based case-control study of 912 members of a health maintenance organization who were receiving standard clinical treatment for hypertension. We found a J-shaped relationship between the most recently measured diastolic blood pressure and the risk of myocardial infarction, the lowest risk occurring at 84 mm Hg. The relative risk of myocardial infarction at 60 mm Hg was 2.07 (95% confidence interval, 0.86 to 5.01), and at 100 mm Hg, 1.45 (95% confidence interval, 1.02 to 2.06). Treated systolic pressure bore a linear relationship to the risk of infarction. We conclude that the optimum target range for diastolic blood pressure in hypertensive patients may be 84 to 90 mm Hg. Levels outside this range may be associated with increased risk of myocardial infarction.

Adrenergic beta-Antagonists↗
PubMed1984

Management of hypertension in the elderly. The case for 'hygienic' measures over drug therapy.

Elderly hypertensive patients form a significant part of our population. Intensive treatment with hygienic measures such as weight loss in patients over ideal weight and dietary salt restriction should be initiated and continued in this group with the help of a supportive physician. Such measures are often effective in lowering blood pressure and in making patients feel and function better. Physicians should realize that a change in lifestyle can be even more difficult for an elderly hypertensive than for a middle-aged or younger patient. Nonetheless, positive change is obtainable for many patients. Antihypertensive drug therapy should be reserved for those patients who, despite continuing observance of the hygienic measures for treatment, have diastolic blood pressure that is consistently above the 105 to 110 mm Hg range.

Aged↗
PubMed1984

Hypertension--indications, goals and potential risks of drug therapy.

Double-blind, placebo-controlled studies show that drug treatment of hypertension does not significantly reduce morbidity and mortality at diastolic pressures less than 105 mm of mercury. Nevertheless, most physicians start drug therapy at 90 to 104 mm of mercury. Few reports have dealt with the level to which blood pressure should be reduced. Available data, including reports from two large-scale studies, suggest that excessively low diastolic pressure due to drug therapy may cause an increase in deaths from coronary heart disease. Other studies suggest that reducing diastolic pressure below 100 mm of mercury does not enhance the prevention of complications of hypertension nor the reversal of pretreatment secondary change. Therefore, it is suggested that drug treatment of hypertension should be begun only if diastolic pressure is consistently 105 mm of mercury despite hygienic measures of treatment. A goal diastolic pressure of at least 100 mm of mercury is suggested.

Antihypertensive Agents↗