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Biomedical subjects

G N Kassil'

Publications and source records attributed to G N Kassil'.

At least 19 recordsLinked to original sources
PubMed1979

[Evaluation of the state of the parasympathetic branch of the autonomic nervous system by cholinergic blood activity].

On the basis of the data obtained during a determination of the cholinergic blood activity in different physiological and pathological conditions of the organism it was possible to evaluate the state (tone and reactivity) of the parasympathetic part of the vegetative nervous system. The conducted studies demonstrate that the cholinergic blood activity depends upon the quantitative relationships between the separate components of the "acetylcholine system" which consists of the free acetylcholine content, bound erythrocytes, the activity of the acetylcholine esterase and the capability of blood in vitro to fixate the added acetylcholine. The pathogenetic therapy in the different forms of disturbed cholinergic blood activity (conditions of parasympathicotonia and parasympathicoatonia) should be directed to a restitution of normal relationships within the acetylcholine complex.

Acetylcholine↗
PubMed1977

[Effect of glucocorticolids on catecholamine synthesis in the heart and adrenals of rats in the presence of physical fatigue].

The influence of the adrenal cortex hormones on the catecholamine synthesis in the adrenal glands and the heart of rats following prolonged swimming (8 hours) was studied. Catecholamine synthesis after the incubation of the adrenal glands and heart in the presence of L-tyrosine was sharply inhibited after swimming. Addition of hydrocortisone or prednisolone in vitro (50 microgram per sample) and also administration of these hormones in vivo (50 mg/kg intramuscularly, 3 hours before decapitation) increased catecholamine synthesis in the adrenal glands of swimming, but not of intact rats. After the incubation of the adrenal glands of swimming rats in the presence of L-DOPA and L-noradrenaline, catecholamine synthesis was depressed in comparison with intact animals, and it failed to be restored on addition of glucocorticoids. No stimulating effect of aldosterone on catecholamine synthesis in the adrenal glands in the presence of L-tyrosine was revealed. Catecholamine synthesis was inhibited and not restored under the effect of glucocorticoids in vitro and in vivo after the incubation of the heart tissue of swimming rats in the presence of L-tyrosine and L-DOPA. A conclusion was drawn that glucocorticoid promoted restoration of catecholamine synthesis inhibiteds in case of strong physical fatique at the stage of tyrosin-hydroxylase.

Adrenal Glands↗