[Use of chelates for removal of excess iron from the body].
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Biomedical subjects
Publications and source records attributed to G N Kol'tsova.
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Racemic 1-O-(epsilon-aminohexanoyl)-2,3-diphosphoglycerol (ADPG) was synthesized. The pH dependence of the 31P-NMR spectra was studied for the ADPG cyclohexylammonium salt. ADPG binding to hemoglobin and its functional activity as a regulator of human hemoglobin reversible oxygenation were assayed.
Bisphosphates of glycols, ethyleneglycol and 1,2-propanediol, were synthesized. These structural analogues of 2,3-diphosphoglyceric acid were shown to reduce significantly the oxygen affinity of stripped hemoglobin.
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