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Biomedical subjects

G N Pershin

Publications and source records attributed to G N Pershin.

At least 19 recordsLinked to original sources
PubMed1982

[Activity of di-N-hydroxyquinoxaline and depot-sulfanilamide derivatives in experimental NAG infection].

In experiments in vitro dioxidineeee was highly effective as regards all the test cultures of NAG-vibrios. The MTC ranged within 1 to 62 micrograms/ml. Bactericidal action of the drug became manifest at concentrations from 4 to 250 micrograms/ml. The derivatives of di-N-oxide quinoxaline, dioxidin and quinoxidine exerted a chemotherapeutic effect and sterilizing action in experimental NAG-infection. The action of the drugs was potentiated upon combined use with lysozyme. As far as depo-sulfanilamides are concerned, sulfalenee was little active, while sulfamonomethoxine ineffective in experimental NAG-infection.

Animals↗
PubMed1980

[Basic trends and the prospects for creating new synthetic chemotherapeutic preparations].

Chemotherapy and chemoprophylaxis play a significant role in control of various infectious diseases. The use of chemotherapeutic drugs is associated with a number of difficulties, such as development of drug resistance in pathogenic microorganism during the treatment, possible toxic effects of drugs on their prolonged use, inefficiency of chemotherapy in bacteria carriers, etc. In spite of the achievements in chemotherapy of acute bacterial infections, tuberculosis, lepra, mycoses, protozoal infections, it is necessary to have available new drugs for the treatment of these diseases. The achievements in chemotherapy of viral infections are relatively modest. However, therapy of such infections is of great importance for medicine. Highly effective broad-spectrum antiviral agents may play a significant role in the control of widely spread viral diseases of man and cattle. Such drugs will be of great significance in prevention of complications in persons with viral infections and studying the diseases of supposed viral etiology. For the successful solution of the problems of chemotherapy, a proper strategy in the development of the research work in this field is of importance.

Anti-Bacterial Agents↗
PubMed1976

[Comparative study of the semisynthetic penicillins in the experimental therapy of pneumococcal and streptococcal infections in mice].

Penicillins were studied comparatively on mice with infections caused by pneumococci and streptococci. It was shown that klomethacillin was superior by its chemotherapeutic effect to other penicillins in treatment of pneumococcal septicemia when used subcutaneously or intragastrically. Ampicillin was superior in treatment of streptococcal infection.

Administration, Oral↗
PubMed1975

[Characteristics of the protein spectra of individual representatives of mycobacteria].

A study of proteinograms of some strains of mycobacteria with the use of the method of electrophoresis in polyacrylamide gel showed that individual strains had characteristic protein spectra which could serve as one of the possible taxonomic characteristics. Analysis of proteinograms of three groups of mycobacteria (tuberculosis, atypical and saprophytes) by electrophoretic mobility of the fractions, with consideration to their homologous character and by the intensity of protein fractions in the mobility zones pointed to heterogeneity of the group of atypical strains and their greater similarity to tuberculosis mycobacteria than to acid-fast saprophytes. Proteinograms of strains H37 Rv and Bov-8 proved to be identical; a marked similarity between the protein spectra of M. avium and M. battey was revealed.

Bacterial Proteins↗