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Biomedical subjects

G N Volans

Publications and source records attributed to G N Volans.

At least 19 recordsLinked to original sources
PubMed1979

A schedule for combined intravenous and oral dosing with mexiletine.

A combined intravenous and oral dosage regime for mexiletine has been evaluated in volunteer subjects. Therapeutically effective plasma concentrations of the drug were achieved rapidly and maintained over a four-hour period. Side-effects were minimal and the scheme would be suitable for the anti-arrhythmic protection of patients being transported to hospital and for the treatment of patients receiving hospital or, even, domicilliary care.

Administration, Oral↗
PubMed1978

Fatal overdosage with disopyramide.

The most common clinical finding in five patients who died after deliberately taking overdoses of disopyramide was an early loss of consciousness after an apnoeic episode. An initial response to resuscitation and antiarrhythmic drugs in four patients was not sustained and these patients deteriorated rapidly with cardiac arrhythmias and loss of spontaneous respiration. At necropsy the appearance of the lungs in four cases was consistent with pulmonary congestion secondary to left ventricular failure.

Adolescent↗
PubMed1978

Drug interactions in rheumatoid disease--are they of any clinical importance?

Much of the literature on drug interactions over-emphasizes their importance. A review of the mechanisms of drug interactions and of the clinically important interactions involving drugs commonly used in rheumatology reveals that serious interactions are likely to be uncommon. A practical approach to this problem may be divided into three parts: 1. Be aware of the mechanisms of drug interactions as they may explain some unexpected finding occurring during drug treatment. 2. Remember that serious drug interactions are more likely to involve a drug which possesses a narrow therapeutic range (e.g. oral anticoagulants). 3. When indulging in polypharmacy attempt to ensure that such treatment has real benefits. This last point may be the most important for if it is proven that combined therapy has no advantages then the potential for drug interactions will be much reduced.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1978

The outcome of pregnancy in women suffering from migraine.

The reproductive histories of 777 women suffering from migraine were compared with 182 non-migrainous women. The incidence of miscarriage, stillbirth and toxaemia of pregnancy was very similar in both groups and there was no increase in the number of congenital malformations in the children born to women who suffered from migraine compared with the control group or with the national average. It was concluded that women suffering from migraine did not have an increased risk of giving birth to children with deformity and it was unlikely that drugs most commonly used in the treatment of migraine were teratogenic.

Abortion, Spontaneous↗
PubMed1977

Digoxin measurements in general practice.

1 As part of a prospective study on the use of digoxin in a general practice, plasma digoxin concentrations were measured in all patients receiving the drug. 2 A low mean plasma digoxin concentration was observed, suggesting a cautious approach to digitalization. 3 The correlation between plasma digoxin concentration and signs or symptoms commonly used in the assessment of digoxin effect was poor. 4 It was concluded that the measurement of plasma digoxin could be of assistance in a variety of clinical settings within a general practice.

Aged↗
PubMed1977

A preliminary controlled evaluation of the antihypertensive effect of indapamide.

A controlled, single-blind trial was carried out in 10 hypertensive patients to compare the effectiveness of a single daily dose (2.5 mg to 5 mg) of indapamide with that of placebo. Blood pressure was measured with a bias-free sphygmomanometer. Indapamide produced a significant reduction in mean systolic and diastolic pressures in both supine and erect positions. It was generally well tolerated: few side-effects were reported and no significant changes were noted in laboratory tests. It is concluded that further long-term studies of indapamide are indicated in larger numbers of patients.

Adult↗
PubMed1976

Oral methionine in the treatment of severe paracetamol (Acetaminophen) overdose.

30 patients at risk of hepatic damage from paracetamol (acetaminophen) ingestion were given 2-5 g oral methionine every four hours up to a total dose of 10 g. The first dose was given within ten hours of the overdose. There were no deaths and no reports of hepatic encephalopathy or other complications. In 21 patients plasma aspartate-aminotransferase remained within normal limits. These results suggest that methionine may be effective in reducing the frequency and severity of paracetamol-induced liver damage and may provide an effective non-toxic alternative to cysteamine.

Acetaminophen↗