Biomedical subjects

G N Wise

Publications and source records attributed to G N Wise.

At least 19 recordsLinked to original sources

PubMed1975

Clinical features of idiopathic preretinal macular fibrosis. Schoenberg Lecture.

Of 150 consecutive cases of preretinal macular fibrosis that occurred predominantly in older subjects, 118 cases involved only one eye while 32 occurred binocularly. The ratio of women to men was 3:2. Visual acuity was usually 20/50 or better, and only four of 178 eyes had acuity below 20/200. The vast majority of lesions involved the macula and few extended outside the macular zone. The characteristic clinical finding on ophthalmoscopy was a glinting reflex probably due to a layer of connective tissue cells lying on the internal limiting membrane. Small white exudates, venous abnormalities, and occasional hemorrhages may also be part of prepretinal macular fibrosis. Amsler grid testing usually demonstrated irregularity and distortion of some part of the grid. Fluorescein angiography revealed a characteristic tortuosity of the small macular vessels. Most eyes had previous posterior vitreous detachments but, except for one possible case, there were no cases where the posterior vitreous body was adherent to either the retinal membrane or the macular region. There was no significant systemic disease related to preretinal macular fibrosis. In most instances, preretinal macular fibrosis either was stationary or slowly progressive. The etiology and treatment of the condition remains obscure.

Adult↗

PubMed1975

Relationship of idiopathic preretinal macular fibrosis to posterior vitreous detachment.

Of 100 consecutive cases of spontaneous posterior vitreous detachment, 20 patients had bilateral posterior vitreous detachments, and 50 patients experienced light flashes just before, or at the moment, that they noticed a floating opacity. Most patients had no loss of vision at the time. A prominent provoking factor rarely caused the detachment. In five cases there were hemorrhages at the disk where the posterior attachment of the vitreous body was torn from the disk margin. Six peripheral retinal holes were found in patients with posterior vitreous detachments and in four, the holes were fresh and three were associated with fresh blood in the peripheral vitreous body. There was no attachment between the posterior face of the receding vitreous body and the macular region. There were no macular pathologic findings in this study and there was no secondary pathology anywhere near the macula at the posterior pole. Spontaneous preretinal macular fibrosis did develop in two cases after posterior vitreous detachment, but only after more than two years and in the absence of any vitreoretinal adhesion.

Adult↗

PubMed1975

Congenital preretinal macular fibrosis.

A 35-year-old woman and a 36-year-old man had asymptomatic, preretinal macular fibrosis involving their left eyes. Both patients were asymptomatic and the lesions were found on routine ocular examination. An opaque gray fibrotic membrane extended toward a lamellar hole in the macular region. Vision, fluorescein angiograms, and Amsler grid testing were normal in both cases. The defect in these two cases possibly arose during early embryonic development and might have been due to a defect produced by adherence of the primary vitreous body to the retina, thus differentiating them from idiopathic preretinal fibrosis,

Adult↗

PubMed1975

Ultrastructure and clinicopathologic correlation of idiopathic preretinal macular fibrosis.

Detailed light and electron microscopic examination of early idiopathic preretinal fibrosis lesions showed that the fibrosis consisted of a layer of glial cells on the retinal surface. Two cases supported the clinical observation that a glinting retinal reflex preceded the development of retinal folds and traction lines. In both cases there was a break in the inner limiting lamina through which glial cells migrated and, presumably, proliferated on the retinal surface. There was no evidence for vitreoretinal adhesions. The ultrastructural similarity of the lesion to preretinal glial membranes seen in other disease entities suggested the possibility of a common biochemical stimulus for glial cell migration and proliferation on the retinal surface.

Aged↗

PubMed1975

Cavernous haemangioma of the retina and optic disc. A report of three cases and a review of the literature.

We report characteristics of three cases of cavernous haemangioma of the retina, bringing to 37 the number now reported in the available literature. This rare, benign, congenital malformation is non-progressive, usually unilateral, somewhat more frequent in women, and rarely a source of intraocular haemorrhage. The fluorescein angiographic features include a normal arterial and venous supply, extraordinarily slowed venous drainage, no arterio-venous shunting, no disturbances of vascular permeability, and no secondary retinal exudation. Almost always, isolated clusters of vascular globules with plasma/erythrocyte sedimentation surround the main body of the malformation. These findings differentiate the anomaly from other retinal vascular diseases. Therapeutic intervention is seldom necessary.

Adult↗

PubMed1974