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Biomedical subjects

G Németh

Publications and source records attributed to G Németh.

At least 163 records · Page 9Linked to original sources
PubMed1981

Experimental study of hormone receptor development in a unicellular model system.

It was shown earlier that diiodotyrosine (T2) stimulates the growth of Tetrahymena. In the present study clonal populations of Tetrahymena, derived from subcultures propagated in the presence of T2, showed a highly significant increase of intra-clone variance over the control, while inter-clone variation was significant, but not decisive. This suggests that genetic factors play a smaller role in the development of the cell membrane receptor pattern tha the genetic variability of the membrane itself, which seems to account for the stabilization of the adequate receptors on first exposure to a hormone.

Analysis of Variance↗
PubMed1981

[Treatment experience with cervix uteri tumors].

During the period of 1946-1972 5279 patients with cervical cancer were treated, which data were processed by an electronic computer. In 83.6% of cases squamous non-keratoid cancer was revealed histologically. Most of patients were admitted in stage II (53.68%). An average of 5-year survival was 44.36%. However, the best results were obtained in treatment of patients being in Stage I, in whom the operation following irradiation showed no tumor tissue in the specimen. A 5-year survival in this group was 88.13%.

Adenocarcinoma↗
PubMed1980

Changes of receptor cooperation in Tetrahymena by re-exposure to hormones.

The hormone combination epinephrine + diiodotyrosine inhibited the growth of Tetrahymena cells on first exposure, but stimulated it markedly on re-exposure. It appears that amplification of the receptor by the hormone does take place at the first encounter, regardless of whether the response of the cells was positive or negative. The amplifying effect persists over several generations. The intensity of stimulation by the second exposure was directly related with the duration of the first one. Prolongation of the first exposure accounted for a switch-over from negative to positive influence.

Animals↗
PubMed1980

Receptor amplifying effect of serotonin and serotonin analogues in a protozoan (Tetrahymena) model system.

A 72-hour treatment of Tetrahymena with serotonin analogues at a concentration of 10(-9) mmole/l resulted in a decrease of the reproduction rate, whereas serotonin itself was ineffective. On the second exposure to antagonists, cellular division was enhanced but its rate remained around or below the control value, while the second exposure to serotonin produced a more marked effect than the first one did, which finding implies a receptor amplification. The most pronounced receptor amplification was caused by the first exposure to serotonin. This observation indicates that the receptor is rather selective as regards the amplification effect.

Animals↗
PubMed1979

New primary malignant tumors in patients treated for carcinoma of the uterine cervix or corpus.

Subsequent primary malignancy was revealed in 1.8 per cent of 2, 689 cases with cervical and in 1.7 per cent of 773 cases with corpus carcinoma. In the cervical carcinoma series the most frequent new primary sites were the skin, breast and recto-sigmoid. Of the cases with cervical and corpus carcinoma 18.8 and 30.7 per cent, respectively, had a family history of malignant disease.

Female↗
PubMed1979

Effect of hormones and related compounds on the multiplication of Tetrahymena.

The vertebrate hormone triiodothyronine, the commonly occurring animal and plant hormone serotonin, and the plant alkaloid gramine, chemically related to the latter, stimulated the multiplication of Tetrahymena. Neither epinephrine nor gibberellin had such an effect. These experimental observations support the previous suggestion that unicellular animals possess structures capable of responding to certain hormones, which do not seem to elicit specific responses of the unicellular animal, but rather act through the activation of certain general functions.

Alkaloids↗
PubMed1978

[Changes in treatment results of 5279 cervix tumor patients between 1946 and 1972].

Results of the treatment of 5279 cervix tumour patients between 1946--1972 are reported. The assessment was performed by computer analysis of the material. There was a parallel rise in the 5 years survival of patients with the growth of radiotherapeutical equipment, mainly in extensive cases. Regarding all stages, the 5 years survival was 44,36%.

Adult↗
PubMed1977

[Quantitative changes of glyco- and mucoproteins in the serum of patients with carcinoma of the uterus during treatment].

The mutations of serum glycoproteid and mucoproteid levels were examined in 40 patients with uterine cancer before, during and 4 years after treatment. In all the patients having become symptom-free the glycoproteid and mucoproteid concentration, that had shown an initial increase before, returned to normal in the course of successful treatment. There could be found no connection between the tumor extension and the otherwise increased serum values in carcinoma of cervix and uterus of stage I. and II.

Cobalt Radioisotopes↗