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Biomedical subjects

G Napo-Koura

Publications and source records attributed to G Napo-Koura.

15 recordsLinked to original sources
PubMed2004

[Tumours of the accessory salivary glands. Epidemiological and anatomopathological aspects].

INTRODUCTION: Several series of studies on the tumours of the accessory salivary glands have shed light on their anatomopathological and epidemiological aspects in Western countries. Only a few studies of this kind have been carried out in our countries. OBJECTIVES: To study the anatomopathological and epidemiological aspects of the accessory salivary glands in order to compare the literature data. METHODOLOGY: This is an analytic, descriptive and retrospective study conducted over a period of 10 years at the ENT and the Anatomo-pathology Departments of the CHU in Lomé. RESULTS: Tumours of the salivary glands represented in our study 17.19% of the ORL tumours. Tumours of the accessory salivary glands represented 71.43% of tumours of the salivary glands. Benign tumours represented 71.43% and malignant tumours 21.43%. Women were more affected than men. The average age of appearance of benign tumours was 47.87 years for men and 31.91 year for women. The average age of appearance of malignant tumours was 38 years far the women. The commonest site was the palate. The majority of benign tumours were pleomorphic adenomas. Adenoid cystic carcinoma was the principal malignant tumor. CONCLUSION: Pleomorphic adenoma and adenoid cystic carcinoma were the principal tumours of the accessory salivary glands. The commonest site was the palate. Women were more affected than men. The average age of appearance of malignant tumours was seven years later than benign tumours. (full article translated in English available on www.ent-review.com).

Adenoma, Pleomorphic↗
PubMed2001

[Is endoscopic diagnosis of Candida albicans esophagitis reliable? Correlations with pathology and mycology].

AIM OF STUDY: To assess the reliability of endoscopic diagnosis of Candida albicans esophagitis. PATIENTS AND METHODS: A case - control prospective study was carried out from November 1997 to July 1998 at the Campus Teaching Hospital of Lome, in patients with esophagitis macroscopically suggestive of Candida albicans origin at upper digestive endoscopy. Fifteen subjects with normal endoscopy served as controls. Esophageal biopsies for mycologic and pathological examination were performed, as well as HIV serology. RESULTS: During the study period, 26 of the 850 endoscopies performed in our Unit revealed an esophagitis suggestive of Candida albicans origin. Mycology confirmed the presence of filamentous form of Candida albicans in 23 patients and pathology showed non-specific lesions of esophagitis, 20 with intramucous hyphae. HIV serology was positive in 19/23 patients (82.6%) and in 1/15 controls (6.6%). Sensitivity and specificity of upper GI endoscopy for the diagnosis of Candida albicans were 100 and 83.3% respectively; positive and negative predictive values were 88.5 and 100%, respectively. CONCLUSION: Upper digestive endoscopy is a reliable method for the diagnosis of Candida albicans esophagitis. However, mycological confirmation is warranted.

AIDS-Related Opportunistic Infections↗
PubMed2001

[Malignant non-Hodgkin's lymphoma of the lip: a case report].

The non Hodgkin's lymphoma of the lip is rare. A 3-year-old child with non-Hodgkin's lymphoma of the upper lip (stage I in the Ann Harbor system) was reported. An immunodeficiency, been in correspondence with a food deficiency, was probably a causal factor. A post-chemotherapy residual lesion justified a surgery.

Anti-Inflammatory Agents↗
PubMed1999

[Primary nephrotic syndrome in the black African child].

Idiopathic nephrotic syndrome (INS) in black African children differs from that of children in temperate areas. The main differences are the high rate of corticosteroid non-responders and the low rate of minimal change glomerulopathy in black African children, possibly related to a racial factor. The identification of a high corticosensibility in certain African regions (Togo and Ghana) can lead to the identification of an ethnic factor. Further genetic studies should be carried out in order to provide a better approach to INS in Africa.

Adrenal Cortex Hormones↗
PubMed1997

[Cutaneous cancers in Togo].

A retrospective study was conducted during 20 years to determine the epidemiological features of skin cancer diagnosed in the pathology laboratory in Lome teaching hospital. During this period, 518 cases of theses affections were noted: 288 cases of carcinoma (56.6%); out of 288 carcinomas 254 were spinocellular carcinoma, which developed on 143 chronic phagedenic ulcer, the others cancer were: malignant melanoma 63 cases (12.3%), Kaposi's sarcoma 72 cases (13.9%), skin sarcoma 95 cases (18.3%). The results of this study shows that the spinocellular carcinoma were mostly the skin cancer in Black African, and confirm the particularity of malignant melanoma in Black subjects.

Adult↗
PubMed1996

[Spinal diseases in a rheumatology hospital unit in Lomé (Togo)].

A retrospective study was conducted to determine the different kinds of spinal diseases in patients attending the rheumatology unit of Lomé hospital, Togo. Among the 4927 patients seen over a 5-year period, 1966 (40%) had spinal involvement. The disease observed were as follows: degenerative spinal disorders: 1872 cases (95%); infectious discitis: 41 cas (2.1%); spondyloarthropathies: 33 cases (1.8%); tumors: 20 cases (1.1%). Degenerative spinal involvement affected mainly lumbar and cervical spine. The only unusual clinical feature was that Schober's index was often normal. Lumbar spinal stenosis was common (233 cases, 12.4%), especially in females, and occurred at an earlier age than in the Western world. Ankylosing spondylitis features included mildness of extra-articular manifestations and an often negative family history. Pott's disease was de leading cause of infectious discitis. The present study suggests that spinal disorders are as frequent in Africa as in Western countries.

Adult↗
PubMed1995

[Coexistence of a partial hydatiform mole and a viable twin pregnancy. A case seen at the Sokode regional hospital (Togo)].

A case was seen of partial hydatidiform mole coexisting with a viable twin pregnancy. Apart from prematurity which created early problems in caring for these girls twins, born with a good Apgar score and birth weights of 1400 g and 1350 g, the outcome was satisfactory for both the mother and daughters, who thrived marvelously. The incidence of this clinical form of trophoblastic disease which is 1/10,000 deliveries in our series confirms it rarity as reported by many authors.

Adult↗
PubMed1995

[Kaposi's sarcoma in dermatology consultations at Lome, Togo].

The purpose of this retrospective study conducted in a dermatologic out patient clinic in Lomé was to assess the epidemiologic, clinical, and prognostic profile of Kaposi's sarcoma in Togo during the 15 years period between 1980 and 1994. Only patients who had undergone serologic tests for human immunodeficiency virus (HIV) were included. There were 30 patients (27 men and 3 women) with a mean age of 35.2 years (range: 17 to 59 years). Thirteen patients were seropositive (epidemic Kaposi's sarcoma or EPK) and 17 were seronegative (endemic Kaposi's sarcoma or ENK). The mean age of patients with EPK was lower than that of patients with ENK (30.0 vs 42.3 years). Extensive (92.3%) and edematous (90%) forms and involvement of the upper extremities (66.7%), trunk (01.6%), and mucosa (92.3%) were characteristic clinical features of EPK while localized nodular forms (92.3%) were characteristic of ENK. A death was noted after 5 years of follow-up in the ENK group as compared to 12 deaths after a mean follow-up of 15.95 years in the EPK group. This study illustrates the current profile of Kaposi's sarcoma in Black Africa where HIV infection has greatly changed clinical findings and prognosis.

Adolescent↗
PubMed1995

[Multiple bone lesions of a type of disseminated African histoplasmosis in a Togolese immunocompetent child].

The authors report one case of disseminated African's histoplasmosis with numerous bones in Togolese immunocompetent child. The left tibia and fibula, the collarbones and the acromion were the bones mostly affected. The chronic fistulate lesion of the left leg associated with skin lesion allowed to evoke the diagnosis, this being confirmed by histological examination. The authors review the different diagnosis which will be discussed considering the radiographic appearance of african's histoplasmosis.

Acromion↗
PubMed1994

[Relapsing polychondritis. Apropos of a case].

The relapsing polychondritis is a rare autoimmune disease. The pathologist finds a fibrous degeneration of the cartilage of the body. A case relapsing polychondritis is presented and the disorders of the disease are reviewed. The larynx and trachea location is a fact of a poor prognosis.

Adult↗
PubMed1991

[Congenital malaria: clinical, parasitological and histological considerations. Apropos of 200 observations collected at the Lomé University Teaching Hospital and Kpalimé Hospital].

An evaluation was conducted of the usefulness of clinical, parasitological and histological parameters for the diagnosis of neonatal pathology due to congenital malaria. Haematozoa detected were invariably Plasmodium falciparum. Their presence in the placenta was considered essential to confirm congenital infection, but needed always to be accompanied by a positive diagnose of the same species in the mother, villous vessels, umbilical cord and peripheral blood of the newborn child. None of these was sufficient diagnosis alone. The existence of congenital malaria as a sickness in its own right appears unlikely, however, the indirect effects of maternal malaria on the foetus suggest prophylactic and individualised treatment is desirable for pregnant women.

Abortion, Spontaneous↗
PubMedDate not supplied

[Prevalence of skin manifestations in AIDS patients in the Lome-Tokoin University Hospital (Togo)].

A prospective study was conducted for 13 months to determine the prevalence of skin disease in AIDS patients in the Lome teaching hospital. 99 of the 120 AIDS patients (75 males, 49 females) examined during this period had skin diseases (82.5% of the cases). This prevalence was 59.99% during 1 to 3 months of AIDS evolution, 81.77% during 4 to 6 months, and 100% after 6 months. The principal skin diseases were: pruritic papular eruption (33.33%), oral candidiasis (25%), herpes zoster (16.16%), hair dystrophies (13.13%), xeroderma (14.60%), furuncle (10%), seborrheic dermatitis (6.66%), Kaposi's sarcoma (5%) and recurrent folliculitis (4.16%). Thus, the skin diseases were common in AIDS patients in Lome, Togo, and tended to be more frequent as immunodeficiency progressed. Dermatological examination remains important in the detection of HIV infection and AIDS.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

[Non-tumor dermatoses diagnosed in the pathologic anatomy laboratory of the Tokoin University hospital center, Lomé (Togo)].

The non-tumorous skin diseases are common in hospital consultation in tropical countries. These infections constitute a great health problem in black Africa. Their diagnosis is often clinically easy, but sometimes histologically examination is necessary to have the positive diagnosis. In Togo, a retrospective study conducted during ten years, allowed to note 516 cases of non-tumoural dermatosis which were histologically diagnosed. The principal infections were: inflammatory dermatosis 339 cases (213 cases were not specific against 108 specific cases predominated by leprosy: 82 cases), epidermal dermatosis (97 cases, predominated by eczema and psoriasis), dermal lesions (44 cases), lesions of dermic and epidermic junction (23 cases), hypodermic (13 cases). The results of this study shows the diversity of non-tumorous dermatosis diagnosed by the histology. The eradication of these diseases in Africa needs to have efficient laboratory diagnosis and research means in every country.

Dermatitis↗