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G Negri

Publications and source records attributed to G Negri.

59 records · Page 4Linked to original sources
PubMedDate not supplied

A microcomputer based interactive system for the recording and automatic analysis of esophageal pH-studies.

A microcomputer based system for the recording and automatic analysis of esophageal pH-studies has been developed. It consists of a microcomputer interfaced with a pH-meter, one video display, two disk-drives for five inch diskettes, one printer and a fully interactive program written in BASIC. Every second, the microcomputer records the values of pH measured by the pH-meter. The options available in the program are: 1) Creation of medical records; 2) pH probe calibration; 3) pH-basal value acquisition; 4) Standard Acid Reflux Test (SART); 5) Acid Clearing Test (ACT); 6) 24-hour pH-monitoring test; 7) Summary of patient's current results; 8) Printing and data file management. Each one of these options provides access to other related functions. This system and its software has the following advantages: 1) it achieves a high standard in the execution of esophageal pH-study tests; 2) it provides an objective real-time analysis of the results; 3) it reduces the total cost of the investigation.

Computers↗
PubMedDate not supplied

[Definition of the T parameter in nasosinusal neoplasms: a CT-MR comparison].

This study was aimed at investigating the value of CT and MRI in the staging of sinonasal tumors. The authors report 22 cases of sinonasal tumors: 7 squamous cell carcinomas, 4 adenoid-cystic carcinomas, 1 mucoepidermoid carcinoma, 6 adenocarcinomas, 1 esthesioneuroblastoma, 1 osteosarcoma, 1 small-cell sarcoma and finally 1 non-Hodgkin lymphoma. No significant differences were observed between CT and MR staging: 2 T2 and 15 T4 lesions were diagnosed in the maxillary sinuses and 3 stage-II and 1 stage-III lesions in the naso-ethmoidal region. Tumor spread was similar in 20/22 cases: MRI excluded the involvement of maxillary and sphenoid sinuses in 2 cases. CT was superior in the assessment of bone destruction particularly at the base of the skull, but MRI better demonstrated intracranial spread. MRI detailed the intraorbital muscles and, in the infratemporal fossa, the pterygoid muscles better than CT. High agreement was observed between CT and histology in 5/7 cases and between MRI and histology in 6/7 cases undergoing craniofacial resection. Seventeen of 22 cases had low to intermediate signal intensity on T1-weighted, PD and T2-weighted MR images. Signal was hyperintense in 5 cases: 1 adenocarcinoma with mucinous features, 3 adenoid-cystic carcinomas and 1 esthesioneuroblastoma. In agreement with literature data, this study confirms CT as the examination of choice in staging sinonasal tumors: nonetheless, MRI yields valuable information in the cases with tumor spread to the muscles and soft tissues.

Adult↗
PubMedDate not supplied

[Radiotherapy of non-neoplastic diseases: the situation in Piedmont].

The authors report the results of a census among the Piedmont region radiation therapy departments during the period 1980-1991 concerning non antineoplastic radiotherapy. Eight out of eleven centers respond to the questionnaire. During the period considered 36,480 patients were treated, with an annual mean of 4056; the number of treated patients varies from 1.2% to over 71.3% in the different centers when compared to the number of neoplastic patients. Arthrosis, osseous angioma, cheloides and verruca were the most treated diseases. Plesioroentgentherapy and roentgentherapy were normally employed; telecesium and telecobalt therapy were also used; only two centers used electron beams or brachytherapy. The doses of radiotherapy were not uniform; also patients' information and follow-up criteria were quite different in the various centers. The authors conclude with a guidelines for future radiotherapy in benign diseases.

Humans↗
PubMedDate not supplied

[Bisphosphonates stimulate the production of basic fibroblast growth factor and the formation of bone marrow precursors of osteoblasts. New findings about their mechanism of action].

BACKGROUND: It has been recently shown that bisphosphonates may affect bone resorption either directly on osteoclast activity or through the mediation of osteoblasts activity. In this experimental study the potential effects of etidronate and alendronate on osteoblastic bone formation are investigated. METHODS: The number of fibroblastic colony forming units (CFU-F) and mineralized nodules (CFU-OB) in murine and human bone marrow cultures, assessed. In addition, the basic-FGF production by human osteoblastic cells MG-63 measured. RESULTS: In murine bone marrow cultures etidronate and alendronate stimulate CFU-F formation with a mean increases vs control of 106 +/- 17% at 10(-5) M and 78 +/- 5% at 10(-7) M respectively (p < 0.001). The formation of bone nodules is inhibited by bisphosphonates at high concentrations (> 10(-6) M) and stimulated at lower concentrations (from 10(-7) M to 10(-9) M for etidronate and from 10(-7) M to 10(-10) M for alendronate; p < 0.001). Similarly, in human bone marrow cultures alendronate increases CFU-F formation with a maximal effect at 10(-10) M (+161 +/- 12% vs control; p < 0.01) and the formation of CFU-OB with a maximal effect at 10(-10) M (+133 +/- 34%; p < 0.001). Finally, etidronate (from 10(-9) to 10(-11) M) and alendronate (from 10(-9) to 10(-12) M) stimulate the b-FGF production by human osteoblastic cells (p < 0.01). CONCLUSIONS: In line with previous histomorphometric and clinical observations, the results obtained indicate that bisphosphonates directly affect osteoblastic cells with a positive effect on bone formation, probably via the stimulation of growth factors.

Alendronate↗