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Biomedical subjects

G Neretto

Publications and source records attributed to G Neretto.

13 recordsLinked to original sources
PubMed1979

[Survival and therapy of multiple myeloma. Apropos of 56 observed cases].

56 cases of myeloma observed since 1956 are reviewed and it is noted that course, prognosis and survival have changed in relation to the improvement in diagnostic procedures and therapeutic aids. The recent introduction of polychemotherapeutic approaches based on theoretical considerations has not yet been fully vetted in the clinic although a higher percentage of remissions compared to that obtained by monochemotherapy would seem to be confirmed. Personal experience with a new polychemotherapeutic schema in advanced myeloma resistant to monochemotherapy + prednisone is reported.

Adrenocorticotropic Hormone↗
PubMed1978

[Non-secreting myeloma].

On the basis of a personal observation, the cases of "non secretory" multiple myeloma reported in the literature are reviewed. A myeloma classification based upon the production and excretion of monoclonal proteins by neoplastic plasmacells is presented together with an evaluation of the different possible pathogenetic mechanisms. The diagnostic criteria of "non secretory" myeloma are discussed and its main clinical problems analyzed.

Humans↗
PubMed1976

Clinical and haematological data in 254 cases of beta-thalassaemia trait in Italy.

The haematological and clinical data in 254 Italian subjects with beta-thalassaemia trait are reported. 46% of the patients were anaemic, 40% complained of weakness, 19% showed enlargement of the spleen and 10% enlargement of the liver. The haemoglobin levels ranged from 8 to 15.5 g/dl with a normal distribution and a mean of 12.73 for males, 10.93 for females and 11.34 for children (4-15 years). Reticulocyte counts and serum bilirubin levels were slightly increased and both showed a statistically significant relationship with haemoglobin levels. The serum iron level was increased in 27% and decreased in 6% of the cases. Haemoglobin A2 concentrations ranged from 3.5% to 8% with a normal distribution and a mean of 5.37; Hb F values were less than 1% in 36% and varied from 1 to 14% in the remainder. Red cell osmotic fragility was decreased in all but 6% of the subjects: low MCV, MCH and MCHC values were observed in 75%, 86% and 10% respectively. A comparison is made between the data and those obtained by other workers.

Adolescent↗
PubMedDate not supplied

[Blood lysozyme level and bone marrow granulocyte reserve].

The relation between granulocyte turnover, as shown by serum lysozyme values, and the marrow granulocyte reserve, evaluated by means of the hydrocortisone test, was determined in 20 patients with metastasised solid tumours or lymphomas undergoing cytostatic and/or radiation management. In addition to confirming the validity of this test as a means of assessing the behaviour of the marrow storage compartment, it pointed to a correlation between the hydrocortisone test and serum lysozyme. High enzyme values, in fact, insofar as they are an expression of accelerated granulocyte turnover may be seen as an indication of reduced marrow function, and thus offer a simple means of predicting reduction of the marrow granulocyte reserve, and hence a possible post-chemotherapeutic leukopenia, in some cases where peripheral leukopenia is not apparent.

Antineoplastic Agents↗