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Biomedical subjects

G Nestoridis

Publications and source records attributed to G Nestoridis.

2 recordsLinked to original sources
PubMed2000

Bladder augmentation.

This paper reviews bladder augmentation, which has been proved to be an effective way of providing a well functioning urine reservoir that protects the upper urinary tract and allows patients to have a good quality of life. Good results have been achieved with the use of all types of bowel segments. Lifetime follow-up and recognition of the complications is mandatory. Very careful patient selection is essential in order to achieve better long-term results. The principle of urothelial preservation, introduced by autoaugmentation, is very promising in the effort to create a compliant urinary reservoir without metabolic disturbance and without the risk of cancer.

Humans↗
PubMed1998

Bladder autoaugmentation in the rabbit using de-epithelialized segments of small intestine, stomach and lyophilized human dura mater.

OBJECTIVE: To develop an animal model of partial detrusorectomy (autoaugmentation) and thus avoid the consequences of the direct contact of intestinal mucosa with the urinary tract in bladder augmentation. MATERIALS AND METHODS: A diverticular urothelial bulge was created and patched with demucosalized segments of small bowel (group A), stomach (group B) and with lyophilized human dura mater (group C). The surgery was performed on 50 New Zealand rabbits which were compared with 10 control animals and killed at 2, 4 and 6 weeks after surgery. Urodynamic studies and cystography were performed before operation and at death, and the augmented bladders examined histologically. RESULTS: Six weeks after the procedure, the mean (SD) bladder compliance was 22.7 (5.7) in group A (intestinal patch. n = 6). 2.3 (0.5) in group B (stomach patch, n = 3). 3.1 (1.9) in group C (lyophilized human dura, n = 3) and 9.4 (0.4) in the control group (n = 4). Histological studies showed residual enteric and gastric mucosa but an intact urothelium under the intestinal patch. CONCLUSION: The results of this experimental study suggest that a demucosalized segment of small bowel is the best material to increase bladder compliance in detrusorectomy (autoaugmentation) as applied in this animal model.

Animals↗