Biomedical subjects

G Neuhäuser

Publications and source records attributed to G Neuhäuser.

152 records · Page 9Linked to original sources

PubMedDate not supplied

[Analysis of diadochokinetic movement. Electronic data processing-aided diadochometry--a contribution to developmental neurologic diagnosis].

A method of objective registration and analysis of diadochokinetic arm movement was tested in normal children and those with signs of minimal cerebral dysfunction (MCD). 44 children aged 4-10 yrs. (9 with the diagnosis of MCD, 31 controls) were investigated. By means of a special device 270 deg. twisting of the forearms were transduced linearly by foam-cushioned clamps at the wrists and a potentiometer into a direct current of 0-2,7 V, respectively. The analog DC signal was digitalized by 0.7 kHz and stored in a calculator, the identification of the first and last sectors were performed on monitor. After removing artificial currents by a special filtering program, the remaining sinus-like curves could be analyzed by a special program (BEWESI). Mathematical analysis was performed by 11 factors respecting right and left arm, unilateral or bilateral twisting. Statistical analysis showed significant differences in some parameters between normal and MCD-children. In addition, a significant difference between the velocity of pronation and supination was evident. The fact that a clear age relation of parameters was found, proves the practicability of this diagnostical method in developmental neurology.

Attention Deficit Disorder with Hyperactivity↗

PubMedDate not supplied

[Degenerative diseases of the extrapyramidal and spinocerebellar system--differential diagnostic references].

Degenerative disorders of the extrapyramidal and spinocerebellar system often have a genetic cause; however, pathogenesis usually is still unknown. Disturbance of neurotransmitter metabolism in Parkinson disease or in some dystonic syndromes offers new therapeutic approaches; in choreatic or athetoid syndromes biochemical factors are only known in some parts. Clinical and neurophysiological differentiation of various dyskinetic disorders is essential to reach better understanding. In children early signs and symptoms are seen which may be caused by different factors and are difficult to diagnose. Similar problems are to be seen in hereditary ataxias which sometimes begin in childhood: Clinical findings are essential to plan for additional investigations.

Athetosis↗

PubMedDate not supplied

[Abnormalities of the central nervous system in the area of the posterior cranial fossa--neuroradiologic and clinical aspects].

Since the introduction of CT, the assessment of ventricular enlargement and follow-up examinations after shunt surgery have become easier. By means of CT coronary and sagittal reconstructions as well as nuclearmagnetic resonance, the pathologic-anatomic changes in malformations with Arnold-Chiari II deformity and Dandy-Walker syndrome are clearly demonstrated. With nuclear magnetic resonance the morphology of structures in the posterior cranial fossa are demonstrated three-dimensionally, and in comparison with CT the method has the advantage that it involves no exposure to radiation. On the other hand, dynamic conditions of the CSF circulation can be evaluated better on the computerized tomogram following intrathecal injection of contrast medium. On the basis of our experience we believe that the different methods are complementary and can often be combined when planning surgery.

Adolescent↗

PubMedDate not supplied

[Analysis of gait using motography in healthy children and patients with neurologic disorders. I: Qualitative analysis].

Light pattern recording of movements is applicable to assess changes in space and time as well by using single photographic pictures. The method called Motografie has the advantage to work with a special light source; therefore, it is useful in clinical practice and research. Data can be analysed by describing pictures (qualitative analysis) as well as by quantitative measurements from the light pattern curves. By using Motografie gait pictures were studied in two healthy children, in a boy with minimal cerebral dysfunction and hyperactivity, and in two patients suffering from spastic diplegia. Movement curves from different parts of the body (shoulders, hands, hips, knees, feet) could be described in regard to their pattern and quality. In comparing healthy, mildly impaired and severely handicapped children specific features were noted to characterize different gait patterns. This is useful in clinical diagnosis and practicable to assess developmental changes as well as results of therapeutic measures in movement disorders.

Adolescent↗

PubMedDate not supplied

[Analysis of gait using motography in healthy children and patients with neurologic disorders. II: Quantitative analysis].

Light pattern recording of movements by Motografie results in data representing changes in space and time; single pictures of these curves can be analysed in detail. The method was used for gait analysis in two healthy children, in a boy with minimal cerebral dysfunction and hyperactivity, and in two patients with spastic diplegia. From describing all phases of gait cycles different variables were chosen to assess movement patterns quantitatively; thus, curves could be described by various parameters. Differences were seen between normal, mildly impaired and severely handicapped children. Results obtained are in good agreement with a qualitative analysis of pictures and with data from the literature using different methods.

Adolescent↗

PubMedDate not supplied

[Huntington chorea in childhood].

By the case report of a 7 years old girl problems and difficulties in diagnosing early manifested Chorea Huntington are discussed. Dementia, rigor and akinesis are the presenting signs; choreatic movements are usually not present. Seizures occur frequently. Family history gives important informations; the autosomal dominant gene mostly is transmitted by the father. Although knowledges of biochemical changes in movement disorders are increasing, there are presently only a few possibilities to ameliorate signs and symptoms of chorea by pharmacological measures.

Child↗

PubMedDate not supplied

Autosomal recessive syndrome of cerebellar ataxia and hypogonadotropic hypogonadism.

An ataxia-hypogonadism syndrome is reported in at least four of 15 family members (two brothers and two sisters). Consanguinity could be proven by genealogical studies; parents were second cousins. The onset of cerebellar ataxia in three sibs was at about 12-20 years, in the proposita at 33-38 years; progression was very slow. Hypogonadotropic hypogonadism was reflected in failure of maturation of secondary sexual characteristics, eunuchoidism, absence of libido and infertility. The concurrence of hereditary ataxia and hypogonadotropic hypogonadism is discussed and explained as pleiotropic effects caused by the homozygous state of a rare autosomal recessive gene. A review of the literature suggests that this is a previously undescribed disorder.

Aged↗

PubMedDate not supplied

[Effects of significantly increased perinatal risks on developmental status in adolescence].

In a 13-years-catamnesis a sample of 50 children with severe perinatal risks was assessed with regard to their physical, cognitive and behavioral development; selective drop-outs were analysed. In accordance with the results of other prospective studies there are deficits in visual-motor functioning, higher rates of somatic complaints, social withdrawal and attention deficits; a large number of these children attend special schools. The study presents predicative relations between risk factors of birth-time and the developmental status at youth. In comparison with typical single risks (e.g. gestational age or respiratory distress syndrome) a complex index for the perinatal risk, the so-called birth-optimality offers no substantial advantage. A significant influence of social factors is shown for school achievement. Children of fathers with higher educational level are attending schools of a higher grade. The combination of biological and social factors improves the reliability of developmental prognosis; the Mental Developmental Index of the Bayley Scales of Infant Development provides additional prognostic accuracy. For compensating developmental disadvantages especially parents with lower educational level should be informed about beneficial care. Even children of these families, who scored low in early cognitive assessments should receive early intervention or therapeutic support.

Adolescent↗