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Biomedical subjects

G Neumann

Publications and source records attributed to G Neumann.

At least 127 records · Page 7Linked to original sources
PubMed1980

Characterization of activity of alkaline phosphatase (AAP) in capillary endothelium of normal and psoriatic skin.

The activity of alkaline phosphatase (AAP) in papillary capillaries of normal and psoriatic skin was characterized by enzyme inhibition studies. Quantitatively, there were pronounced differences between normal and psoriatic skin, i.e., increase of AAP, as determined by a grading system, and assimilation of the strength of AAP in venous and arterial side of the capillary loop in psoriasis. Qualitatively, the inhibition studies with different actin inhibitors revealed no difference between AAP in normal and psoriatic skin or between initial, fully developed and healed psoriatic lesions as well as noninvolved skin of psoriatics. Thus, the physiologic AAP seems to be stimulated in psoriasis. Generally, AAP of dermal capillaries is highly sensitive to cysteine inhibition.

Alkaline Phosphatase↗
PubMed1980

A new highly potent and short-acting analgesic, carfentanyl (R 33799), in combination with the hypnotic agent, etomidat (R 26490), as a method of anaesthesia in guinea pigs.

Anaesthesia in guinea pigs with a new highly potent and short-acting analgesic, carfentanyl (R 33799), combined with the hypnotic, etomidat (R 26490), is reported. Clinical observations as well as respiratory and circulatory variables have revealed this combination to be safe. Profound surgical anaesthesia has been obtained with good sedation, analgesia, and immobilisation. This method has been evaluated clinically and can be recommended with confidence in this species.

Anesthesia↗
PubMed1980

Effects of monocular deprivation in the lateral geniculate nucleus of the cat: an analysis of evoked potentials.

The effects of monocular deprivation on excitatory post-synaptic activity in the lateral geniculate nucleus and on the afferent activity to the geniculate in the cat were examined. Field potentials elicited by electrical stimulation of the optic nerves were recorded and analysed. This approach revealed that the most severe effects of deprivation originate at the input stage to the lateral geniculate nucleus. 1. The membrane currents resulting from excitatory post-synaptic activity in the geniculate are at least a factor of two smaller in amplitude in the deprived than in the non-deprived laminae, indicating a severe reduction of synaptic strength. This effect is equally pronounced for activity mediated by the X- and the Y-system and has to be considered as the major origin of the imbalance of activity from the deprived and non-deprived eye apparent in cortex. 2. Judged from amplitudes and latencies of compound action potentials in the optic tract, afferent Y-activity is not affected by deprivation. This indicates that the number of afferents from the retina of the deprived eye to the geniculates is not significantly reduced by deprivation. 3. During several periods of recording conduction block in the afferents from both eyes was observed.

Animals↗
PubMed1980

Bacteriological examination of specified-pathogen-free animals: a procedure for small rodents.

Organs of 10 mice or 5 rats were pooled and homogenized. A portion of the homogenate was cultured on several selective and enrichment media. The method was tested by adding various pathogenic organisms to organ homogenates. 10(3)-10(4) microorganisms in homogenates of 10 organs were readily detected. This procedure allows even a small microbiological laboratory to detect a low frequency of infected animals in a colony.

Animals↗
PubMed1980

[Studies into diagnostic value of detection of antibody to Candida in patients with vaginal mycosis (author's transl)].

The indirect immunofluorescence test for the detection of antibody to Candida was checked for its diagnostic usefulness on pregnant and non-pregnant women with vaginal mycosis. The test proved to be effective in detecting humoral antibody to Candida also in cases of vaginal mycosis. However, comparison between patients with vaginal mycosis, on the one hand, and those without, on the other, did not yield substantive difference in titre distribution. Hence, this serological method cannot be considered adequate for diagnosis for vaginal mycosis.

Antibodies, Fungal↗
PubMed1980

Relationships among retinoid structure, inhibition of growth, and cellular retinoic acid-binding protein in cultured S91 melanoma cells.

S91 melanoma cells, which are sensitive to retinoic acid and contain a cellular retinoic acid-binding protein (RABP), were used in an investigation of the possible correlation between the capacities of various retinoids to inhibit cell proliferation and to bind to the RABP. Each of 27 different retinoids was evaluated for growth-inhibitory activity by exposing S91 melanoma cells to various retinoid concentrations between 1 nM and 10 microM. Subsequently, the ability of 17 of these retinoids to compete with [3H]retinoic acid for binding to RABP was determined. The results demonstrate that in addition to retinoic acid, many retinoids are capable of inhibiting the proliferation of S91 melanoma cells, although some are considerably less active. A positive correlation was found between the abilities of retinoids possessing a free carboxyl group at carbon 15 to inhibit cell proliferation and to bind to RABP. The structure-activity relationships established with the S91 cells are compared with previous reports on the biological activities of various retinoids in other systems.

Animals↗
PubMed1979

[Abnormal myocardial blood flow distribution with a normal coronarogram in angina pectoris and after myocardial infarction].

It is reported on the selective coronary perfusion scintigraphy in 47 patients with angina pectoris and condition after myocardial infarction, which was performed simultaneously with the coronary angiography. For the paper were interesting the cases with normal coronarogram, but pathological perfusion scintigram. 3 of 25 patients with condition of infarction showed coronarographically inconspicuous vessels. In all cases the perfusion scintigram shows disturbances of regional perfusion, which corresponded with the electrocardiographic localisation of the infarction. In 3 of 22 patients with angina pectoris with normal coronarogram in the scintigram regional changes of the terminal vascular system were established. In 2 cases simultaneously a disturbance of rhythm and stimulus conduction was present, which showed a conspicuous correlation to the perfusion lesions in the septum. In the small intramural vessels haemodynamically effective changes take place which are below the coronarogram. Therefore, the only coronarography is not enough to confirm or to refuse a genuine angina pectoris or an infarction. The selecitve coronary perfusion scintigraphy gives the possibility to prove disturbances of the distribution of regional blood supply without a greater additional load of the patient as to coronary angiography. However, it cannot give evidence on the genesis of disturbances in the terminal vascular system in the normal coronarogram

Adult↗
PubMed1979

[Anesthsiological experiences in experimental surgery].

The paper reports experience with methods of anaesthesia in rabbits, rats, mice, guinea-pigs, pigs, sheep, baboons, dogs and cats. Special problems of handling, mode of injection and intubation are discussed. A comprehensive survey of literature provides further information about the proposed patterns of anaesthesia and informs about other anaesthetic methods, not practised by the authors.

Alcuronium↗