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Biomedical subjects

G Nikolov

Publications and source records attributed to G Nikolov.

At least 19 recordsLinked to original sources
PubMed1988

[The value of Wagner and Selvester's electrocardiographic point indices for assessing global and regional function of the left ventricle in patients with ischemic heart disease].

The study includes 45 patients with ischemic heart disease. The reproducibility of Selvester's QRS-point index was examined by two researchers (r = 0.98). Between the ejection fraction of the left ventricle and the ECG-pont indices there exists a reverse relation, the correlation coefficients being equal (r = -5.58). Between the segmental disturbances of the left ventricular wall movements, examined by the systolic shortening in percentage of the radial axes, and both ECG indices there is also an equal correlation (r = 0.59). The relation between the angiographically evaluated segmental disturbances and the ejection fraction is also reverse, r = -0.88. The results of the study prove the relatively great possibility for mistakes of only the routine rest ECG is analyzed. The ECG evaluation of the left ventricular function cannot disclose the compensatory reserves of the healthy myocardium.

Adult↗
PubMed1987

[Dissecting aortic aneurysm].

Twenty cases with aortic dissecting aneurysm (ADA) are presented, at an average age of 52.5 (from 14 to 75), 15 of them males and 5--females. Nineteen had acute form of the disease and 1--chronic. Etiology, clinical picture, diagnostic approach and treatment were analyzed. Pain as leading symptom was present in all patients with various intensity and predominantly antero-thoracal localization. Seventeen of the patients (70%) were in shock at admittance. Pulse asymmetry was established in 8 (40%) and in 4, out of 12 cases (33%) with ADA, complicated by cardiac tamponade, a freshly appeared diastolic murmur was present. Enlarged aortic shadow at X-ray investigation had 14 (70%) of the patients with a dynamics of the enlargement in 5 patients. The disease has been clinically diagnosed in 19 (95) of the patients. Five out of 20 patients underwent operation, two of them followed for two years after the surgical treatment. Only one patient out of the non-operated 15 patients, survived. The modes of therapeutic behaviour are discussed on the base of the authors' experience and literature data.

Adolescent↗
PubMed1986

[Diagnostic value of the Holter monitoring of ischemic heart disease patients].

Holter-monitoring, for 24 hours, has been performed to with 47 patients (12 females and 35 males), average age 59,05 +/- 10,98. All patients had ischemic heart disease, 13 with myocardial infarction in a subacute stage, 10--with postinfarction cicatrix, 7 with unstable angina pectoris, 4 with the syndrome of the morbid sinus node and 13--with myocardial sclerosis. Rhythm disorders were recorded in only 12 patients (25.5%). Ventricular extra systoles were recorded in 31 patients (65.9%), 70.97% being from class III-V according to Lown. Ventricular tachycardia was established in 8 patients (25.8%), with 3 paroxysms within 24 hours on the average. Transitory absolute arrhythmia was established in 4 cases and in 12-atrial extrasystoles. The incidence and class of ventricular activity, according to nosological entities were analyzed. Ventricular tachycardia in 87.5% was triggered by relatively late extra-systoles. The antiarrhythmic treatment, administered in the moment, proved not to be effective in the majority of the patients. The importance of holter-monitoring was stressed on both for registration and documentation of the various rhythm disorders and for the evaluation of the effectiveness of the treatment.

Aged↗
PubMed1986

[Treatment of light and moderate arterial hypertension with acebutolol].

The authors follow up the effectiveness and tolerance of monotherapy with acebutolol in 47 patients with light and moderate hypertension, in a dose of 400-1200 mg in the course of three months. Twenty two of the patients have been treatment with the original French drug of the firm "Specia" and the rest 25--with the Bulgarian preparation, produced by Pharmachim according to a licence of the French one. The following parameters were followed up: arterial pressure, pulse rate, ECG, eventual adverse effects on 30, 60, 90 day of the treatment. The indices of cardiac output and total peripheral vascular resistance were calculated in a group of 13 patients. The results obtained reveal that the monotherapy with acebutolol, in light and moderate arterial hypertension, leads to definite, lasting and progressive antihypertensive effect in over 75% of the patients. The preparation has no significant effect on pulse rate and induces no orthostatism. It affected the total peripheral vascular resistance with 26% from the initial with unchanged or lightly increased indices of cardiac output. The Bulgarian drug, produced by Pharmachim, gives no way in effectiveness to the original French preparation.

Acebutolol↗
PubMed1982

[Therapeutic and preventive effect of oral lidocaine in extrasystole].

Lidocaine, Egypt production, P. R. of Hungary, was perorally administered in an average dose of 1.8 +/- 0.38 gr daily for a period of 14.23 +/- 28.9 days to 52 patients with and average age of 61,52 +/- 12.8 with various organic cardiac diseases and ventricular extrasystolic arrhythmia. In 18 of them (47.38%) complete inhibition of arrhythmia was attained, in 10 (26.31%) a combination with another antirhythm preparation was necessary and in 10 (26.31%) the treatment had no effect. In 14 patients the peroral lidocaine form followed its intravenous infusion in acute myocardial infarction with a prophylactic aim and no rhythm disorders were observed. It was established that the unaffected cases were with proportional growth, depending on the severity of arrhythmia, classified according to the prognostic indices of Lown. In 13.46 per cent of the patients, adverse effects were observed, mainly from the gastrointestinal system. The authors think that lidocaine is a proper drug in the treatment of ventricular extrasystolic arrhythmia in the first two classes of Lown and in the prophylaxis of the patients with rhythm disorders after acute myocardial infarction.

Acute Disease↗
PubMed1982

[Treatment of chronic congestive failure with vasodilators (acute trial with prazosin and erythrityl tetranitrate)].

An acute clinical experiment was carried out with 34 patients with chronic refractory cardiac insufficiency with stasis and idiopathic dilating (stasis) cardiomyopathy so as to follow up the hemodynamic effect of the vasodilators prazosin and erythrityl tetranitrate. The values of the central and peripheral vascular hemodynamics were followed up before and one hour after the peroral intake of 2 mg prazosin and half an hour after the peroral intake of 40 mg erythrityl tetranitrate. The results indicate that a statistically significant decrease of the arterial pressure and the total peripheral vascular resistance developed after prazosin intake. The systolic arterial pressure was decreased from 121,80 +/- 3,52 to 102,40 +/- 3,71 (p less than 0,001) and the diastolic--from 80,20 +/- 2,41 to 68,20 +/- 2,56 (p less than 0,01). The values of the total peripheral vascular resistance were decreased from 2629,65 +/- 174 to 1865,53 +/- 153 (p less than 0,001). The indices of the pump function--Stl and SI were increased (Stl from 22,74 +/- 1,85 to 30,37 +/- 2,14 with p less than 0,025 and Sl--from 1,90 +/- 0,08 to 2,64 +/- 0,19; p less than 0,02). The indices of the pressure in the left ventricular filling had no statistically significant change. After the administration of erythrityl tetranitrate, a statistically significant improvement of the indices of the cardiac output was also observed as well as of the total peripheral vascular resistance. The systolic index grew from 1,74 +/- 0,20 to 2,70 +/- 0,16 (p less than 0,01); stroke index--from 18,35 +/- 2,82 to 32,99 +/- 2,88 (p less than 0,01), and the total peripheral vascular resistance was decreased from 2897,0 +/- 186,0 to 1556,0 +/- 154,0 (p less than 0,001). Prazosin and erythrityl tetranitrate led to a considerable decrease of the counter load of the heart and improvement of the pump function of left ventricle in an acute experiment in case of chronic cardiac insufficiency with stasis.

Adult↗
PubMed1981

[Vasodilator treatment of chronic heart failure: a chronic double-blind trial with prazosin and erythrityl tetranitrate].

A chronic double-blind experiment was carried out with 32 patients with severe chronic stasis cardiac insufficiency, with concomitant idiopathic congestive cardiomyopathy and ischemic heart disease, in assessing the effect of vasodilators prazosin or erythrityl tetranitrate upon the decompensation symptomatics and hemodynamic indices. The clinical indices of cardiac insufficiency with hemodynamic signs of pre-loading, myocardial contractility and postloading of left ventricle were followed up. Besides vasodilators the patients were administered the ordinary maintenance therapy with digoxin and diuretics. The experiment was a double blind one, controlled by placebo-periods and covered a 6 months follow-up period. The combined venous-arteriolar vasodilator prazosin was reduced pre and post-loading, it increased the cardiac output, without essential changes in functional capacity of the patients with chronic cardiac insufficiency. Erythrityl tetranitrate, however, has no substantial effect on the clinical and hemodynamic indices of statis cardiac insufficiency even in higher doses. That suggests the necessity of the chronic cardiac insufficiency treatment to be carried out with vasodilators with venous and arteriolar effect.

Chronic Disease↗
PubMed1978

[Clinical trial of the preparation clofazolin used intravenously].

The authors studied the hypotensive effect of the Bulgarian preparation Chlophazolin in ampoules of 0,15 mg, administered i. v. The study covered 50 patients, 44 of them with hypertonic disease II and III stage and the rest (6)--with renal and renovasal hypertension. The i. v. administration of chlophazolin was established to have a marked hypotensive effect and be expedient for the treatment of hypertonic crises and hypertension with high values. In a dose of 0,15 mg i. v. the preparation leads to a sharp decrease in the first 20 min, whereas during the following hours it is kept to lower values: systolic pressure-an average decrease of 30-40 mm Hb in a lying position, to 45-50 mm Hg in an erect position; the diastolic pressure-an average decrease of 10-15 mm Hg in a lying position to 20-25 mm Hg in an erect position. The hypotensive effect is better manifested in higher initial values of the pressure. It lasts approximately more than 13 hours but in 1/5 of the patients, with higher values of blood pressure, its effect is exhausted within 6-8 hours. Side effects of the preparation were registered in 26 per cent of the cases; orthostatic disturbances, sleepiness, dryness of the mouth, nausea. I. v. administration of chlopazolin does not change the excretion of urea and creatinine, diuresis and serum levels of sodium, potassium and chlorine.

Adolescent↗
PubMed1977

[Cardiocirculatory complications and ECG changes in patients operated on for severe deformations of the anterior chest wall].

After a brief literature review on the indidence of these diseases, the authors present a comprehensive analysis of a group of 117 patients, operated and treated by them, for the period from 1968 t0 1975 includ. They discuss in details the cardiocirculatory complications and ECG changes in those patients undergone operations for severe deformities of the anterior chest wall. Their observations and results obtained are well illustrated in three tables. Furthermore, they try to explain why those electrocardiographic changes do no disappear after the carried out operation treatment. Finally, they propose the inclusion of a new stage in the operation treatment of these patients, being a significant contribution to the operation treatment and the definite elimination of ECG changes.

Adolescent↗
PubMed1976

[Indications for temporary and permanent cardiac electrostimulation].

The author suggests a classification of the indications for cardiac eletrostimulations based on the analysis of his own clinical observations upon a series of 308 patients, treated by different cardiac electrostimulation methods and upon literature date. The results of his observations are illustrated in four tables, after a brief review of the methods most frequently applied, taking in consideration their positive and negative aspects from a point of view of his observations in comparison to those found in the literature. At the end, practical conclusions are drawn for the proper application of that treatment in everyday clinical practice with a view to raising the problem of founding a department or centre for cardiac electrostimulation, due to the constant number increase of those patients and because this problem is not solved in our country so far.

Arrhythmias, Cardiac↗