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Biomedical subjects

G Nitulescu

Publications and source records attributed to G Nitulescu.

4 recordsLinked to original sources

Demonstration of two distinct macrophage specific antigenic determinants in rats.

Exhaustive cross-absorptions of rabbit anti-rat alveolar macrophage sera with peritoneal macrophages and of anti-rat peritoneal macrophage sera with alveolar macrophages did not prove the existence of antigenic determinants specific for alveolar or peritoneal macrophages. Titer-differences of these sera on RAM and RPM seem to be caused by a different distribution of two or more macrophage specific determinants present in both cell populations. Macrophages from other rat tissues show reactivity with these two sera different as well from alveolar as from peritoneal macrophages.

Animals↗

Quantitative measurement of delayed hypersensitivity in the guinea pig paw.

To facilitate quantitative measurement of a delayed hypersensitivity reaction, a tuberculin reaction was produced in the paws of sensitized guinea pigs and the resulting edema estimated by one of the usual techniques. The edema formation was shown to be an expression of the delayed hypersensitivity reaction. Optimal conditions for this reaction were assessed. This model may be used for testing the influence of drugs on delayed hypersensitivity reactions.

Animals↗