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G Nord

Publications and source records attributed to G Nord.

3 recordsLinked to original sources
PubMed1995

Investigation of mortality and morbidity associated with severe self-injurious behavior.

A retrospective study was conducted to determine whether severe self-injurious behavior was associated with shortened lengths of life or greater sensory impairments for Minnesota Regional Treatment Center residents with developmental disabilities. The client records of 209 institutionalized individuals who died between January 1, 1980, and December 31, 1989, were reviewed. The data revealed that the 29 clients who exhibited severe self-injury did not live significantly shorter lives compared to matched cohorts without self-injury. However, those clients with severe self-injury were found to have a significantly higher incidence of vision and hearing impairments than did the matched cohorts. Implications of these findings were discussed.

Adolescent↗
PubMed1993

The binding of a complex cobalt ruthenium polyamine by deoxyribonucleic acid and a lipopolysaccharide: a model for a novel class of drugs.

In this paper we discuss the following: 1. Synthesis of [Co(H3CsarNHCH2pyRu(NH3)5)] (PF6)5, (CoRu). 2. Interaction of CoRu with calf thymus DNA and with lipopolysaccharide from Escherichia coli C (LPS) has been estimated using the absorption of the complex at 242 and 420 nm. 3. DNA and LPS increase the rate of fall of absorption at 420 nm due to autooxidation of the complex. 4. The fall in absorption of CoRu(II) at 420 nm can be used to give an approximate measure of binding to DNA and to LPS. 5. Both macromolecules are aggregated by CoRu at high concentrations and the cation and macromolecule complex can be removed by low speed centrifugation. 6. The DNA-CoRu complex can also be removed by high speed centrifugation when the cation concentration is too low to cause aggregation (20 microM CoRu/155 microM DNA-P). Absorption of redissolved complex at 420 nm is restored by reduction with ascorbic acid. 7. At saturation the ratio of mole CoRu bound/mole DNA-P is 0.16.

Ascorbic Acid↗