Biomedical subjects
Publications and source records attributed to G Oddi.
A concordance study of 6 infectious diseases of childhood has been carried out in a sample of 656 twin pairs classified by sex and zygosity. A new approach is proposed to estimate the respective influence of heredity and of common environment. The estimates thus obtained range from 86% hereditary component in the case of measles to 100% environmental component in the case of scarlet fever.
The electron microscopic observation of 2 parathyroid adenomas led to detection, in addition to elements which can also be found in nonneoplastic cells and related to the functional state, of organelles more characteristically associated with neoplastic cells. Indeed, intracytoplasmic cilia and annulate lamellae are commonly regarded as an expression of cellular atypia rather then distinctive of the adenoma cell. Moreover, our study seems to show that annulate lamellae are correlated with the hormonal synthesis more than with the rate of growth of the neoplastic tissue.
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Although the histogenesis of meningeal hemangiopericytomas (HMP) remains controversial, both biological and clinical evidence seems to identify these neoplasms as a separate entity with respect to meningiomas. In order to assess the current prognosis of HMP we reviewed our personal experience limited to the last decade (1986-1995): during this period 7 patients (4M, 3F) were treated by surgery alone or surgery combined with postoperative radiotherapy. In spite of meticulous attempts at radical resection, the tumors recurred in all but two cases with a mean interval of 85 months, and a total of 18 operations were performed (2.57/patient; range 1-4). Massive intratumoral hemorrhage determined acute deterioration and required emergency surgery in two cases while in one patient diffuse visceral metastases were discovered at autopsy. Five patients are still alive at follow-up but only 2 of them are in good neurological conditions and without evidence of disease. These results are similar to those reported in other series. In view of our results we conclude that intracranial hemangiopericytomas still have a dismal prognosis. Advances in neuroimaging, neuroanesthesia, microneurosurgery and adjuvant therapy do not seem to have significantly affected the recurrence rate, quality of life and mortality.
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Observation on value of estrogen and progesterone receptors in intracranial meningiomas. The authors take into consideration twenty intracranial meningiomas reperted in patients that differ for age, sex and histological pattern of the lesions, for value receptor content and their variability with mentioned variants. They report receptors contents of meningiomas and its variability with age and histological pattern.
Primary cardiac tumors are rare in children. The benign forms constitute 90% of cases, with often fatal clinical course due to the origin site. Here is reported a case of fibroelastic hamartoma in a four month baby, with multiple malformations, in which the initial signs have been alterations of ECG and of the cardiac profile at Rx chest. Bidimensional echocardiography suggested the correct diagnosis, revealing the mass in the interventricular septum. Cardiac catheterization excluded connections with coronary arteries. The baby died before cardiosurgical operation, probably because of a hyperkinetic ventricular arrhythmia. Anatomo-pathologic examination discusses the diagnosis of this tumor versus other kinds, defining our case as a fibroelastic hamartoma.
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Esthesioneuroblastoma or olfactory neuroblastoma is a rare tumor of the nasal cavities and paranasal sinuses. In the majority of cases the cerebral involvement is secondary. Only ten cases have been reported in which the tumor was primarily intracranial. An eleventh case is reported and literature reviewed.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.