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Biomedical subjects

G Ogilvie

Publications and source records attributed to G Ogilvie.

11 recordsLinked to original sources
PubMed2005

Incorporating a social networking approach to enhance contact tracing in a heterosexual outbreak of syphilis.

OBJECTIVE: This report describes the outcomes of a social networking approach (SNA) in a heterosexually transmitted syphilis epidemic by street nurses in British Columbia, Canada. METHODS: Street nurses used SNA interviewing cues, environmental observation, peer outreach, serial interviewing, conducted blood tests, and offered treatment on the street. Rates of cases of syphilis identified by outreach nurses and cases linked to another case were compared before and after adoption of an SNA. RESULTS: SNA resulted in a significantly increased proportion of cases identified by the street nurses (p = 0.01) and increased the percentage of cases linked to a previous case (p = 0.03). CONCLUSION: This preliminary study confirms that SNA can increase the number of cases and contacts identified in an epidemic of a sexually transmitted disease in a vulnerable, hard to reach population.

British Columbia↗
PubMed2000

The histologic classification of 602 cases of feline lymphoproliferative disease using the National Cancer Institute working formulation.

Case information and histologic slides for 688 admissions of feline tissues from 12 veterinary institutions were assembled and reviewed to determine tissues obtained by biopsy or necropsy, age and sex of cat, tumor topography, feline leukemia viral antigen status, histologic frequency of mitoses, diagnosis, presence of necrosis, and presence and degree of sclerosis. Histologic sections were examined to place the lesions in one of the diagnostic categories of the National Cancer Institute working formulation (NCI WF) for lymphomas or lymphoid leukemia. Correlations between the various factors determined were tested using contingency tables and chi-square analysis to provide a statistical comparison between the levels of observations determined by case examination with the numbers expected from chance alone. Significant correlations (P < or = 0.05) were found between diagnosis and tumor topography, the frequency of mitoses, necrosis, sclerosis, and age, between mitoses and necrosis, topography, age, and feline leukemia viral infection status, between topography and necrosis and age, and between leukemia viral status and age. Significant correlations between diagnosis and tumor topography included a greater than expected number of cases of acute and chronic lymphoid leukemia and multicentric distribution of tumor. Small cell lymphomas were more frequent than expected in enteric and cutaneous areas and less frequent than expected in mediastinal, renal, and multicentric areas. In contrast, the high-grade small noncleaved type of lymphomas was found significantly more frequently than expected in the mediastinum and less frequently than expected in enteric tissues. In comparing diagnosis and frequency of mitoses, the lymphomas classified as low grade by the NCI WF were significantly more frequent than expected in the lower categories (0-2/100x) of mitoses, and those classified as high-grade lymphomas were more frequent than expected in the higher categories (4-8/1OOx) of mitoses. In comparing diagnosis and sclerosis, diffuse sclerosis was more frequent than expected for the intermediate grade lymphomas of mixed cell type and for the high-grade lymphomas of the immunoblastic polymorphous type. In comparing diagnosis and locally extensive necrosis, this feature was more frequently observed than expected for cases of intermediate grade lymphoma of the small-cleaved cell category and for the high-grade lymphoma of the immunoblastic cell type. In comparing mitoses and necrosis, the lower grade lymphomas were, in general, characterized by a lower frequency of mitoses and a lower incidence of necrosis then would be expected from chance alone. In contrast, the higher grade lymphomas were characterized by more frequent mitoses and a higher incidence of necrosis. In tests comparing mitoses and tumor topography, lymphomas of the alimentary tract were more frequently observed than expected in the category with the lowest level of mitoses (0-1/100x), whereas lymphomas of the mediastinum and kidney were more frequently observed than expected in the categories with a higher level (4-20/ 100x) of mitoses.

Animals↗
PubMed1999

Rearranged T lymphocyte antigen receptor genes as markers of malignant T cells.

We have recently cloned a number of canine T cell receptor (TCR) Vbeta genes using degenerate oligonucleotides. From the DNA sequences of the resulting clones and the canine Vbeta gene sequences in the literature, seven distinct canine TCR Vbeta genes were identified. Vbeta specific PCR primers were designed for each of the seven TCR Vbeta genes such that under defined conditions, each primer could only amplify a specific TCR Vbeta gene in conjunction with the same 3' constant region (Cbeta) primer. By performing RT-PCR on RNA derived from a source containing T lymphocytes, the presence and expansion of T cells expressing a particular Vbeta gene could be detected. Moreover, the clonality or diversity of a T cell population under analysis could be easily determined by the VDJ junctional sequence of the amplified Vbeta PCR product, in the form of a "DNA fingerprint". These findings have been used to detect canine T cell lymphoma, and could potentially be used to monitor the remission of T cell malignancies in response to treatment.

Animals↗
PubMed1998

The problem-based medical audit program: influence on family practice residents' knowledge and skills.

BACKGROUND AND OBJECTIVES: Family physicians need to possess the skills to conduct audits in their own clinical settings to ensure that their patients receive exemplary clinical care. Residency offers an important opportunity for physicians to develop these auditing skills. This study describes the introduction of a problem-based medical audit program at three teaching units in the Department of Family Medicine at McMaster University and the program's effect on learner knowledge, skills, and attitudes toward the practice audit. METHODS: A survey designed to assess residents' self-rated knowledge, skills, and attitudes toward practice audits was distributed before and after residents participated in the audit program. RESULTS: Forty-three residents were surveyed; 33 (76.7%) completed the initial questionnaire and follow-up questionnaire. Residents reported significant improvements in their understanding of the relevance of audits, ability to develop a practice audit question, skills in designing methodology, and skills needed to conduct an audit independently. Residents also reported a moderate increase in their knowledge of statistics needed to complete an audit. CONCLUSIONS: The practice audit program at McMaster University uses a problem-based model to introduce learners to the concept of the clinical audit. The practice audit program successfully improved the residents' self-reported ability to conduct an audit and heightened their understanding of the importance and relevance of the audit process.

Commission on Professional and Hospital Activities↗
PubMed1997

Do physicians discuss HIV testing during prenatal care?

OBJECTIVE: To determine the frequency with which Hamilton, Ont, general practitioners and family physicians discussed and offered HIV testing during prenatal care. DESIGN: Cross-sectional mailed survey. SETTING: Family physicians' and general practitioners' offices in Hamilton, including group or solo private practices and community health centres. PARTICIPANTS: General practitioners and family physicians in Hamilton identified from the Ontario Medical Association and the 1995 Canadian Medical Directory. Two hundred forty-one practitioners were sent surveys; 25% had moved or no longer practised family medicine, and 65% (140 of 216) were returned. MAIN OUTCOME MEASURE: Frequency with which physicians discuss with and offer HIV testing to prenatal patients. RESULTS: Eighty percent of clinicians felt they understood their professional role in providing HIV testing, and more than 90% had referred female patients for HIV testing. Eight percent of physicians always discussed HIV when reviewing pregnancy care, and 5% always offered HIV testing to patients in the first trimester of pregnancy. CONCLUSIONS: Currently, few physicians discuss HIV testing with all their prenatal patients.

Cross-Sectional Studies↗
PubMed1987

Generalized demodicosis associated with diabetes mellitus in two cats.

Generalized demodicosis with concurrent diabetes mellitus was diagnosed in 2 cats. Both cats had generalized alopecia and a bilateral brown aural exudate. Mites were seen microscopically in skin scrapings and ear swab specimens. Histologic examination of the skin showed the follicular orientation of the mites. Abnormal results on oral dexamethasone suppression tests, clinical findings, and bilateral adrenal hyperplasia found on necropsy of one of the cats suggested concurrent hyperadrenocorticism.

Animals↗
PubMed1987

A comparison of two types of epidural catheters.

The purpose of this study was to compare two epidural catheters--the Portex epidural catheter and Vas-Cath catheter. One hundred and fifty patients in labour who received epidural anaesthesia were selected and either one or the other catheter was used, based on random assignment. Ease of insertion, maintenance and removal of the catheter were assessed, as was the incidence of blood return and paraesthesiae during epidural catheter insertion. There were no significant differences between the catheters as far as insertion, maintenance and removal were concerned. However, the incidence of paresthesiae was 44 per cent with the Portex and 24 per cent with Vas-Cath catheters (p less than 0.008). The incidence of blood vessel trauma was 12 per cent with the Portex and 6.7 per cent with the Vas-Cath catheter (p = NS). Choice of epidural catheter is a factor to be considered in minimizing the incidence of blood vessel trauma or paresthesiae.

Anesthesia, Epidural↗
PubMedDate not supplied

Salivary gland neoplasia in the dog and cat: survival times and prognostic factors.

Twenty-four dogs and 30 cats with histopathologically confirmed salivary gland neoplasia were retrospectively reviewed in a multi-institutional study. The predominant presenting complaint for animals with salivary gland neoplasia was that of a mass being noted by the owner; other common complaints included halitosis, dysphagia, and exophthalmia. Siamese cats were overrepresented, indicating a possible breed predisposition. The most common histopathological type was simple adenocarcinoma. Cats had more advanced disease at diagnosis than did dogs, and clinical staging was prognostic in dogs. The median survival times for dogs and cats were 550 days and 516 days, respectively.

Adenocarcinoma↗